Results from the first three rounds of the Scottish demonstration pilot of FOBT screening for colorectal cancer

Steele, Robert; McClements, Paula L.; Libby, Gillian; Black, Robert B.; Morton, C.; Birrell, Janice; Mowat, N. A. G.; Wilson, J. A.; Kenicer, M; Carey, Francis A.; Fraser, Callum G.

doi:10.1136/gut.2008.162883

Cited by 158 publications

(202 citation statements)

References 20 publications

Supporting

Mentioning

172

Contrasting

Unclassified

Order By: Relevance

“…This mirrors findings from the Scottish feasibility trials where Dropouts were also balanced by Late Entrants (Steele et al, 2009). …”

Section: Discussionsupporting

confidence: 78%

“…Reports on rates of re-participation in the literature are scarce and inconsistent, and vary depending on country and whether the data comes from randomised controlled trials, feasibility studies or full programs (Jansen, 1984;Kewenter et al, 1988;Hardcastle et al, 1996;Hart et al, 1997;Faivre et al, 1999;Mandel et al, 1999;Jorgenson et al, 2002;Weller et al, 2007;Lindholm et al, 2008;Steele et al, 2009). Some studies failed to invite firstround non-participants in subsequent rounds (Kronborg et al, 1989) although our results show that this would be unwise in organised programs because such people may become Late Entrants.…”

Section: Discussionmentioning

confidence: 65%

See 1 more Smart Citation

Predictors of Re-participation in Faecal Occult Blood Test-Based Screening for Colorectal Cancer

Cole¹,

Gregory²,

Whibley³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: There is little information on longitudinal patterns of participation in faecal occult blood test (FOBT) based colorectal cancer (CRC) screening or on demographic or behavioural factors associated with participation in re-screening. The lack of an agreed system for describing participatory behaviour over multiple rounds also hampers our ability to report, understand and make use of observed associations. Our aims were to develop a system for describing patterns of participatory behaviour in FOBT-based CRC screening programs and to identify factors associated with particular behavioural patterns. Methods: A descriptive framework was developed and applied to a data extract of screening invitation outcomes over two rounds of the NBCSP. The proportion of invitees in each behaviour category was determined and associations between behaviour patterns and demographic and program factors were identified using multivariate analyses. Results: We considered ReParticipants, Dropouts, Late Entrants and Never Participants to be the most appropriate labels for the four possible observed participatory categories after two invitation rounds. The screening participation rate of the South Australian cohort of the NBCSP remained stable over two rounds at 51%, with second round Dropouts (10.3%) being balanced by Late Entrants (10.5%). Non-Participants comprised 38.7% of invitees. Relative to Re-Participants, Dropouts were older, more likely to be female, of lower SES, had changed their place of residence between offers had a positive test result in the first round. Late Entrants tended to be in the youngest age band. Conclusions: Specific demographic characteristics are associated with behavioural sub-groups defined by responses to 2 offers of CRC screening. Targeted group-specific strategies could reduce dropout behaviour or encourage those who declined the first invitation to participate in the second round. It will be important to keep first round participants engaged in order to maximise the benefit of a CRC screening program.

show abstract

“…This mirrors findings from the Scottish feasibility trials where Dropouts were also balanced by Late Entrants (Steele et al, 2009). …”

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 65%

Predictors of Re-participation in Faecal Occult Blood Test-Based Screening for Colorectal Cancer

Cole¹,

Gregory²,

Whibley³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Individuals who attend screening have a 25% reduction in their risk of dying from CRC. These studies supported similar results from trials in Nottingham (Hardcastle et al, 1996;Steele et al, 2009;UK-Colorectal-Cancer-Screening-Pilot-Group, 2004). The use of flexible sigmoidoscopy has also been investigated as a screening tool (Atkin et al, 1993;UK-Flexible-Sigmoidoscopy-Screening-Trial-Investigators, 2002) which showed that a once-only flexible sigmoidoscopy between the ages of 55 and 64 could reduce CRC incidence by 33% and mortality from CRC by 43% .…”

Section: Why Screen For Bowel Cancer?supporting

confidence: 78%

Pathology of Staging of Early Colorectal Lesions During Surveillance Programmes

Salmo¹,

Haboubi²

2011

Colonoscopy

View full text Add to dashboard Cite

“…1 Three demonstration pilot screening rounds, inviting all 50-69-year-olds, and using gFOBT alone, were carried out in 2000 -2, 2002-4 and 2005 -7 in three NHS Boards in Scotland, namely Fife, Grampian and Tayside. 2 The experience gained from the demonstration rounds informed the development of the Scottish Bowel Screening Programme (SBoSP). Roll-out of the SBoSP began in June 2007 and is now complete.…”

mentioning

confidence: 99%

Experience with a two-tier reflex gFOBT/FIT strategy in a national bowel screening programme

Fraser

Digby²,

McDonald³

et al. 2011

J Med Screen

View full text Add to dashboard Cite

Objectives To evaluate a two-tier reflex guaiac-based faecal occult blood test (gFOBT)/faecal immunochemical test (FIT) algorithm in screening for colorectal cancer. Setting Fourth screening round in NHS Tayside (Scotland). Methods gFOBT were sent to 50-74-year-olds. Participants with five or six windows positive were offered colonoscopy. Participants with one to four windows positive were sent a FIT and, if positive, were offered colonoscopy. Participants providing an untestable gFOBT were sent a FIT and, if positive, were offered colonoscopy. Outcomes following positive results, cancer stages and key performance indicators were assessed. Results Of 131,885 invited, 73,315 (55.6%) responded. There were 66,957 (91.3%) negative, 241 (0.3%) strong positive, 5230 (7.1%) weak positive and 887 (1.2%) untestable results. The 241 participants who had five or six windows positive had more cancers than those positive by other routes: only 3 of the 30 cancers (9.7%) were Dukes' A. Among the 983 positive results from the weak positive gFOBT then positive FIT route, there were fewer cancers and more normal colonoscopies, but more adenomas than in the group with a strong positive gFOBT. In those with an untestable gFOBT, 77 had a positive FIT result, with fewer true and more false positive results than in the other groups. Fewer males had cancer and stages were earlier than in females, but more had adenoma. The detection rate for cancer was 0.18% and the PPV for cancer and all adenomas was 41.3%. Conclusions The algorithm and FIT following a weak positive gFOBT have advantages. FIT following an untestable gFOBT warrants review.

show abstract

Results from the first three rounds of the Scottish demonstration pilot of FOBT screening for colorectal cancer

Abstract: These results are compatible with those of previous randomised trials done in research settings, demonstrating that population-based colorectal cancer screening is feasible in Scotland and should lead to a comparable reduction in disease-specific mortality.

Cited by 158 publications

References 20 publications

Predictors of Re-participation in Faecal Occult Blood Test-Based Screening for Colorectal Cancer

Predictors of Re-participation in Faecal Occult Blood Test-Based Screening for Colorectal Cancer

Pathology of Staging of Early Colorectal Lesions During Surveillance Programmes

Experience with a two-tier reflex gFOBT/FIT strategy in a national bowel screening programme

Contact Info

Product

Resources

About