“…Premedication, given to subjects studied as inpatients, will mask many side effects of drugs. Furthermore, earlier studies of abortion blood losses have used insensitive measurement techniques (Cullen et al, 1970;Loung et al, 1971; Lauerson and Conrad, 1974 Reports have suggested that a myometrial stimulant such as ergometrine will fail to prevent the high blood losses at abortion that may be associated with modifications in anaesthetic methods (Dunn et al, 1973) and the same drug has caused clinical difficulties at operation by inducing bronchospasm (Sellers, 1979) or collapse (Valentine, 1977). Despite this, ergometrinecontaining preparations continue as the most widely used ecbolics during legal termination of pregnancy.…”