“…Multiple studies have evaluated this treatment protocol and identified a variety of factors associated with failure [1-4, 6-12, 16, 17, 20, 23-26]. These include increased number of comorbidities, previous surgery, and initial diagnosis of rheumatoid arthritis versus osteoarthritis [8,16]. Although virulence of the infecting organism has been presumed to be a risk factor for reinfection, these studies were not able to demonstrate causation between infection with a methicillin-resistant organism and failure of two-stage exchange arthroplasty.…”