Results of a double-blind, randomized study to evaluate the efficacy and safety of Antibiophilus® in patients with radiation-induced diarrhoea

Abstract

Overall, there was a highly favourable benefit/risk ratio in favour of Antibiophilus.

Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: a randomised study

“…Lactobacillus rhamnosus GG has been found to alleviate diarrhoea caused by a viral infection or Clostridium difficile, and to be useful in the prevention of traveller's diarrhoea or diarrhoea related to administration of antibiotics (Ouwehand et al, 2002;Vaarala, 2003). Probiotics may also reduce radiation therapy-related diarrhoea (Salminen et al, 1988;Urbancsek et al, 2001;Delia et al, 2002). The mode of action is not fully understood, but probiotics are involved in some cytoprotective processes, such as induction of heat-shock protein expression in intestinal epithelial cells (Tao et al, 2006), and prevention of cytokine-induced epithelial cell damage (Yan et al, 2007).…”

“…Three studies have suggested that Lactobacillus acidophilus, L. rhamnosus, or a probiotic mixture may prevent radiotherapyinduced diarrhoea (Salminen et al, 1988;Urbancsek et al, 2001;Delia et al, 2002), but to our knowledge no controlled study has evaluated probiotics or fibre in the prevention of chemotherapyassociated diarrhoea. In the present study, we assessed the efficacy of L. rhamnosus GG and guar gum supplementation in reducing 5-FU-based chemotherapy toxicity.…”

Role of nutritional intervention in patients treated with radiotherapy for pelvic malignancy

“…However, methodology was often weak, with reporting of method of randomisation, concealment of allocation and blinding lacking from many papers (Brown et al, 1980;Foster et al, 1980;Kinsella et al, 1981;Moriarty et al, 1981;Stryker and Bartholomew, 1986;Salminen et al, 1988;Karlson et al, 1989;Bye et al, 1992;Chowdhury et al, 2002;Delia et al, 2002). The choice of randomisation in papers that reported their methodology was adequate in two studies (Urbancsek et al, 2001;Martin et al, 2002). Intention-to-treat analyses were described in two papers (Urbancsek et al, 2001;Martin et al, 2002).…”

Dietary Supplement Use in Cancer Care: Help or Harm

“…No toxicity was noted with the Lactobacillus therapy. A different L. rhamnosus strain, also called Antibiophilus, was given in a randomized, double-blind fashion to 206 subjects receiving abdominal and pelvic radiation [144]. Subjects receiving the probiotic had fewer bowel movements with a trend toward statistical significance (P < .1), with a significantly better consistency of fecal material (P < .05).…”

“…Lower incidence of new disease, new metastases, or death; increased time to relapse [102,103] Probiotics in biliary cancer patients undergoing surgery; colorectal cancer patients undergoing chemotherapy; patients receiving abdominal and pelvic radiation Lower postoperative infection rates; decreased gastrointestinal toxicity (diarrhea) with less hospital care and less reduction in chemotherapy; decreased incidence of diarrhea [106,[143][144][145][146] Glutamine in variety of cancer patients undergoing chemotherapy and radiation Decreased rates and severity of mucositis, neuropathy, and intestinal toxicity; decreased use of pain medication in stomatitis patients; improved nutrition in stomatitis patients; improved ADL in neuropathy patients [112-119, 137-139, 148-150] Vitamin E topically in children undergoing bone marrow transplant; in adults undergoing chemotherapy or radiation to head and neck area Improved stomatitis [122,124,125] Zinc in head and neck patients during radiation therapy Improved stomatitis [126,127] (continued on next page) Chamomile extract as mouthwash in chemotherapy and radiation Improved stomatits sometimes [129,130] Homeopathic remedy including Arnica montana in chemotherapy Improved stomatitis [132] Proteolytic enzymes in head and neck patients with radiation…”