Results of a Multidisciplinary Treatment Program in 3-Year-Old to 5-Year-Old Overweight or Obese Children

Bocca, Gianni; Corpeleijn, Eva; Stolk, Ronald P.; Sauer, Pieter J. J.

doi:10.1001/archpediatrics.2012.1638

Cited by 64 publications

(115 citation statements)

References 30 publications

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“…However, this difference was not statistically significant. At the end of the treatment period, children in the multidisciplinary intervention group showed a larger decrease in BMI (−1.2 (1.0) kg/m 2 , mean (SD) vs. −0.6 (1.1)), BMI z-score (z-BMI) (−0.5 (0.4) vs. −0.3 (0.4)) and waist circumference z-score (z-WC) (−0.3 (0.5) vs. 0.0 (0.6)) compared with children in the usualcare group, as previously described (11). Also, children in the multidisciplinary intervention group showed a statistically significant decrease in body fat percentage (BF%) (−1.5 (3.4)), in contrast to no statistically significant decrease observed in the usual-care group (−0.3 (4.0)).…”

Section: Metabolism In Child Obesity Interventionsupporting

confidence: 61%

“…Details on this study have been described previously (11). In brief, children aged 3-5 y were referred to the outpatient clinic by youth health care physicians, general practitioners, or other physicians if they had a z-BMI > 1.1.…”

Section: Methodsmentioning

confidence: 99%

“…Also, children in the multidisciplinary intervention group showed a statistically significant decrease in body fat percentage (BF%) (−1.5 (3.4)), in contrast to no statistically significant decrease observed in the usual-care group (−0.3 (4.0)). However, the mean difference in the change in BF% between both groups was not statistically significant (11). Table 1 shows the details at baseline on serum lipids, parameters for glucose metabolism, and markers for low-grade systemic inflammation and adipokines, for the multidisciplinary intervention group and usual-care group.…”

Section: Metabolism In Child Obesity Interventionmentioning

confidence: 97%

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Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile, and low-grade inflammation in 3- to 5-y-old children

et al. 2013

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Background: Childhood obesity can cause the development of cardiovascular risk factors. We assessed the effect of a multidisciplinary intervention program on cardiovascular risk factors and compared this effect with a usual-care program in 3-to 5-y-old overweight or obese children. Methods: Seventy-five children were randomly assigned to a multidisciplinary intervention or a usual-care program. Anthropometry, body composition, and abdominal adipose tissue were assessed at the start and end of a 16-wk program. Concurrently, fasting concentrations of serum lipids, glucose, insulin, HbA1c, leptin, adiponectin, high-sensitive C-reactive protein (hsCRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were determined. results: In both groups, insulin sensitivity improved, demonstrated by decreased insulin concentrations and a decreased HOMA2-IR. In the multidisciplinary intervention group, there was also a decrease of HbA1c and TNF-α. In the usual-care group, an increase in glucose concentrations was found. Comparing both groups, changes over time were not different, besides trends in the decrease in total cholesterol and TNF-α, in favor of the multidisciplinary intervention group. Combining the results of both groups, a correlation was found between the decrease in body fat percentage (BF%), and both HOMA2-IR and triglyceride (TG) concentrations. conclusion: In 3-to 5-y-old children, both obesity intervention programs improved insulin sensitivity, in parallel with a reduced BF%. r ecent data have shown that the prevalence of childhood overweight and obesity in the Netherlands is still increasing (1). Childhood obesity is a risk factor for the development of insulin resistance (IR), dyslipidemia, and hypertension at a later age, together described as metabolic syndrome (MS) (2). MS cannot be diagnosed in children under the age of 10 y (3). However, increased concentrations of the separate components of MS have already been demonstrated in children aged 6-9 y (4).Systemic low-grade inflammation may be an underlying cause of MS, induced by the release of inflammatory cytokines from adipose tissue, and even more so from visceral adipose tissue (5,6). Increased concentrations of tumor necrosis factor (TNF)-α, high-sensitive C-reactive protein (hsCRP), and interleukin (IL)-6 have been found in obese children aged 9-13 y (7,8). The adipose tissue hormone adiponectin has anti-inflammatory properties, demonstrated by the significant inverse correlation with markers of inflammation in obese children (8). Whether these deleterious processes related to obesity are already present in overweight and obesity at a very young age is unknown, and no data on systemic low-grade inflammation are available in very young obese children.Multidisciplinary lifestyle intervention programs for obese children have proven to be successful in reducing weight (9). Recent studies demonstrated that weight loss in obese children aged 6-11 y also reduced low-grade inflammation and IR (4,8). In obese children, 9-13 y old, weight loss over a 1-y p...

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Section: Metabolism In Child Obesity Interventionsupporting

confidence: 61%

Section: Methodsmentioning

confidence: 99%

Section: Metabolism In Child Obesity Interventionmentioning

confidence: 97%

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Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile, and low-grade inflammation in 3- to 5-y-old children

et al. 2013

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“…At 12 months after the start of both programs, children in the multidisciplinary intervention group showed greater decreases in BMI-z and WC-z compared with children in the usual-care group. 13 During the follow-up period of 36 months, a significant overall treatment effect on a reduction in BMI-z and abdominal SCF was present for the multidisciplinary intervention group. Combining the results from both groups, body fatness tended to increase again 18 months after the start of the intervention.…”

Section: Discussionmentioning

confidence: 86%

“…13 In short, children and parents participated in a randomized, controlled clinical trial at the "Groningen Expert Center for Kids with Obesity (GECKO)-Outpatient Clinic". Children aged 3e5 years were referred to the outpatient clinic if they had a BMI-z >1.1.…”

Section: Methodsmentioning

confidence: 99%

Three-year follow-up of 3-year-old to 5-year-old children after participation in a multidisciplinary or a usual-care obesity treatment program

et al. 2014

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Diminishing Importance of Screening and Treating Children for Vesicoureteral Reflux After a First Urinary Tract Infection

Keren

2012

Arch Pediatr Adolesc Med

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Results of a Multidisciplinary Treatment Program in 3-Year-Old to 5-Year-Old Overweight or Obese Children

Abstract: To assess the effects of a multidisciplinary intervention program for 3-year-old to 5-year-old overweight and obese children compared with a usual-care program.

Cited by 64 publications

References 30 publications

Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile, and low-grade inflammation in 3- to 5-y-old children

Effect of obesity intervention programs on adipokines, insulin resistance, lipid profile, and low-grade inflammation in 3- to 5-y-old children

Three-year follow-up of 3-year-old to 5-year-old children after participation in a multidisciplinary or a usual-care obesity treatment program

Diminishing Importance of Screening and Treating Children for Vesicoureteral Reflux After a First Urinary Tract Infection

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