Results of a New Human Recombinant Thrombin for the Treatment of Arterial Pseudoaneurysm

Malgor, Rafael D.; Labropoulos, Nicos; Gasparis, Antonios P.; Landau, David; Tassiopoulos, Apostolos K.

doi:10.1177/1538574411431346

Cited by 8 publications

(13 citation statements)

References 18 publications

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“…The overlying skin is sometimes erythematous. The patient may describe a history of catheterization or trauma, and he may note that the pulsatile mass is gradually expanding [1][2][3].…”

Section: General Conceptsmentioning

confidence: 98%

“…Kickuth et al [9] reported a 40-yearold man with severe haemophilia A and high responding inhibitors presenting with recurrent knee joint haemorrhage after bilateral knee prosthetic surgery despite 462 Blood Coagulation and Fibrinolysis 2013, Vol 24 No 5 Table 1 Current options for the treatment of pseudoaneurysms [1][2][3] …”

Section: Kneementioning

confidence: 98%

“…Many options exist for the treatment of pseudoaneurysms (Table 1). Although surgery was the gold standard treatment in the past, several less invasive treatment options are popular today [1][2][3].…”

Section: General Conceptsmentioning

confidence: 99%

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Pseudoaneurysms in haemophilia

Rodríguez-Merchán

2013

Blood Coagulation &Amp; Fibrinolysis

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The incidence of bleeding as a result of a pseudoaneurysm in haemophilia is very low. The diagnosis should be suspected if the patient has a history of arterial trauma. Pseudoaneurysms can appear anywhere where trauma occurs. This can include arterial access for catheterization, blunt trauma or penetrating trauma. The diagnosis should be confirmed using Duplex ultrasonography, computed tomography (CT) angiogram or conventional angiogram. Many options exist for the treatment of pseudoaneurysms. Although surgery was the gold standard treatment in the past (surgical ligation with or without distal bypass), several less invasive treatment options are popular today. They include covered stent, ultrasound probe compression and ultrasound-guided thrombin injection. So far, only 14 pseudoaneurysms have been reported in patients with haemophilia: nine were located in the musculoskeletal system (four in the hand, four in the knee, one in the ankle), whereas five were non-musculoskeletal. Early diagnosis and treatment of this complication is vital. Endovascular treatment offers a minimally invasive treatment option. If arterial embolization fails to solve the pseudoaneurysm, open vascular surgery with surgical ligation with or without distal bypass should be performed. Whatever the procedure, a correct surgical haemostasis must be achieved by the infusion of factor concentrate (recombinant or plasma-derived) at the right dose and tranexamic acid. The advent of activated prothrombin complex concentrates and recombinant factor VIII (rFVIIa) has made invasive procedures possible in haemophilia patients with high-titre inhibitors.

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“…The overlying skin is sometimes erythematous. The patient may describe a history of catheterization or trauma, and he may note that the pulsatile mass is gradually expanding [1][2][3].…”

Section: General Conceptsmentioning

confidence: 98%

Section: Kneementioning

confidence: 98%

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Pseudoaneurysms in haemophilia

Rodríguez-Merchán

2013

Blood Coagulation &Amp; Fibrinolysis

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“…Less invasive management techniques have been described [3, 17–19]. In cases where the pseudoaneurysm is not easily accessible, endovascular stents can be placed over the vessel defect to prevent blood flow through the pseudoaneurysm, causing thrombosis of the blood within the aneurysm.…”

Section: Discussionmentioning

confidence: 99%

“…Complications of this procedure include stent migration, persistent leakage of blood into the pseudoaneurysm, and infection [17, 18]. Ultrasound-guided thrombin injection is another proposed treatment of pseudoaneurysms, whereby thrombin is directly injected into the pseudoaneurysm allowing it to clot [19]. This technique should not be used if there is an arteriovenous fistula in addition to the pseudoaneurysm, as distal thrombus formation can occur with thrombin injection [19].…”

Section: Discussionmentioning

confidence: 99%

Man with a Forehead Mass: Detection of a Forehead Pseudoaneurysm with Bedside Ultrasonography

Abdi

Armijo

Seif

et al. 2014

Case Reports in Emergency Medicine

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A vascular pseudoaneurysm can present similarly to an abscess; yet incision and drainage of a pseudoaneurysm can lead to uncontrolled bleeding and expose the patient to further morbidity. This is a case of a patient with a forehead pseudoaneurysm who presented to our emergency room after blunt head trauma. Here we review different diagnostic modalities as well as some of the treatment options that are described in the literature.

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AIUM Practice Parameter for the Performance of Peripheral Arterial Ultrasound Examinations Using Color and Spectral Doppler Imaging

2021

J of Ultrasound Medicine

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Results of a New Human Recombinant Thrombin for the Treatment of Arterial Pseudoaneurysm

Abstract: The new human recombinant thrombin (Recothrom) is a safer nonimmunogenic option with similar success rates of other fibrin glue sealants.

Cited by 8 publications

References 18 publications

Pseudoaneurysms in haemophilia

Pseudoaneurysms in haemophilia

Man with a Forehead Mass: Detection of a Forehead Pseudoaneurysm with Bedside Ultrasonography

AIUM Practice Parameter for the Performance of Peripheral Arterial Ultrasound Examinations Using Color and Spectral Doppler Imaging

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