Results of Arthroscopic Versus Open Arthrotomy for Surgical Management of Cranial Cruciate Ligament Deficiency in Dogs

Hoelzler, Michael G; Millis, Darryl L.; Francis, D. A.; Weigel, Joseph P.

doi:10.1111/j.1532-950x.2004.04022.x

Cited by 99 publications

(133 citation statements)

References 24 publications

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“…This finding may be linked to the period of confinement to which the animals of T60 and T90 were subjected for data collection, with restriction of physical activity and the consequent reduction of the muscle tone. Similar results were reported by Hoelzer et al (2004) and Serrato et al (2007). The radiographic projection provided less overlapping of structures and the best visualization of the defect was the mediolateral, although the medial and lateral femoral condyles are not uniform and therefore do not properly overlap in this projection.…”

Section: Day 5 Day 10 Day 15supporting

confidence: 82%

Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Eleotério

Borges

Pontes³

et al. 2012

Rev. Ceres

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RESUMO Sulfato de condroitina e glucosamina na reparação de defeitos osteocondrais em cães -análise clínico-radiográficaDentre os tratamentos propostos para a doença articular degenerativa (DAD), os nutracêuticos condroprotetores à base de sulfato de condroitina constituem uma terapia não invasiva que favorece a manuteção da saúde da cartilagem. Além de utilizados em humanos, foram também disponibilizados para uso veterinário administrados na forma de suplemento nutricional independentemente de prescrição, uma vez que possuem somente o registro do Serviço de Inspeção Federal, que não exige testes de eficácia e segurança. A falta desses testes pelo Ministério da Agricultura Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs -clinical-radiographic analysis 1Among the proposed treatments to repair lesions of degenerative joint disease (DJD), chondroprotective nutraceuticals composed by glucosamine and chondroitin sulfate are a non-invasive theraphy with properties that favors the health of the cartilage. Although used in human, it is also available for veterinary use with administration in the form of nutritional supplement independent of prescription, since they have registry only in the Inspection Service, which does not require safety and efficacy testing. The lack of such tests to prove efficacy and safety of veterinary medicines required by the Ministry of Agriculture and the lack of scientific studies proving its benefits raises doubts about the efficiency of the concentrations of such active substances. In this context, the objective of this study was to evaluate the efficacy of a veterinary chondroprotective nutraceutical based on chondroitin sulfate and glucosamine in the repair of osteochondral defects in lateral femoral condyle of 48 dogs, through clinical and radiographic analysis. The animals were divided into treatment group (TG) and control group (CG), so that only the TG received the nutraceutical every 24 hours at the rate recommended by the manufacturer. The results of the four treatment times (15, 30, 60 and 90 days) showed that the chondroprotective nutraceutical, in the rate, formulation and administration at the times used, did not improve clinical signs and radiologically did not influence in the repair process of the defects, since the treated and control groups showed similar radiographic findings at the end of the treatments.

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Section: Day 5 Day 10 Day 15supporting

confidence: 82%

Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Eleotério

Borges

Pontes³

et al. 2012

Rev. Ceres

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“…Trained surgeons with extensive experience with this procedure performed the stifle arthroscopy and TPLO according to Kowaleski et al to decrease variability between dogs in terms of pain and joint inflammation (9). Stifle arthroscopy was preferred over stifle arthrotomy to better assess meniscal tears and decrease joint inflammation and pain in the postoperative period (50, 51). Furthermore, anesthetic and intraoperative and postoperative analgesic protocols were standardized.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effect of a Single Intra-articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells Compared to Oral Non-Steroidal Anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau Leveling Osteotomy: A Pilot Study

Taroni

Cabon

Febre³

et al. 2017

Front. Vet. Sci.

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ObjectiveCompare the clinical and pressure walkway gait evolution of dogs after a tibial plateau leveling osteotomy (TPLO) for a cranial cruciate ligament rupture (CrCLR) and treatment with either a 1-month course of non-steroidal anti-inflammatory drugs (NSAIDs) or a single postoperative intra-articular (IA) injection of allogeneic neonatal mesenchymal stromal cells (MSCs).Study designProspective, double-blinded, randomized, controlled, monocentric clinical study.AnimalsSixteen client-owned dogs.Materials and methodsDogs with unilateral CrCLR confirmed by arthroscopy were included. Allogeneic neonatal canine MSCs were obtained from fetal adnexa retrieved after C-section performed on healthy pregnant bitches. The dogs were randomly allocated to either the “MSCs group,” receiving an IA injection of MSCs after TPLO, followed by placebo for 1 month, or the “NSAIDs group,” receiving IA equivalent volume of MSCs vehicle after TPLO, followed by oral NSAID for 1 month. One of the three blinded evaluators assessed the dogs in each group before and after surgery (1, 3, and 6 months). Clinical score and gait and bone healing process were assessed. The data were statistically compared between the two groups for pre- and postoperative evaluations.ResultsFourteen dogs (nine in the MSCs group, five in the NSAIDs group) completed the present study. No significant difference was observed between the groups preoperatively. No local or systemic adverse effect was observed after MSCs injection at any time point considered. At 1 month after surgery, bone healing scores were significantly higher in the MSCs group. At 1, 3, and 6 months after surgery, no significant difference was observed between the two groups for clinical scores and gait evaluation.ConclusionA single IA injection of allogeneic neonatal MSCs could be a safe and valuable postoperative alternative to NSAIDs for dogs requiring TPLO surgery, particularly for dogs intolerant to this class of drugs.

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“…Thigh girth measurements have been used to assess progress following surgical management of cranial cruciate ligament repair and canine total knee arthroplasty and its use has been explored for other purposes (9–11). One study found that thigh circumference was statistically decreased compared to the unaffected contralateral limb in dogs 1 and 5 years after stifle stabilization surgery for naturally occurring cranial cruciate ligament disease (12).…”

Section: Introductionmentioning

confidence: 99%

Variables Affecting Thigh Girth Measurement and Observer Reliability in Dogs

et al. 2018

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Objective: The purpose of the study reported here was to describe variables affecting thigh girth measurements preoperatively and 2 weeks after surgical stabilization of the stifle and to examine inter- and intra-observer reliability.Animals: Ten hound-type dogs with experimental, unilateral, cranial cruciate ligament transection, and surgical stabilization.Procedures: Dogs were placed in lateral recumbency for measurements of thigh circumference after the stifle was placed in flexed (F), estimated standing (S), and extended (E) positions. Measurements were made at 50 and 70% of thigh length (TL), with hair unclipped and then clipped prior to surgery, before and 2 weeks after cruciate ligament transection and stifle stabilization, and with and without sedation. A spring tension measuring tape was used to determine thigh girth that allowed a consistent amount of end-tension to be applied to the tape. All measurements were made by two blinded individuals in triplicate, data were recorded for each set of measurements and the mean of the three measurements for each condition was used for analysis.Results: Thigh girth was significantly greater at the more proximal site of 50% TL (36.7 ± 2.6 cm) when compared to the 70% TL (31.7 ± 2.7 cm) (P = 0.001). Sedation did not significantly affect thigh girth at any stifle position at the 70% and 50% TL. Although there were no differences in thigh circumference between the flexion and standing positions at 50% TL (F 38.2 ± 2.8 cm, S 38.1 ± 2.9 cm) and 70% TL (F 33.6 ± 1.6 cm; S 33.6 ± 1.8 cm), full extension of the stifle resulted in significantly less thigh girth (50% TL 36.6 ± 2.6 cm, P = 0.006; 70% TL 31.7 ± 2.6 cm, P = 0.006). Significant decreases in thigh girth were seen after surgery in all limb positions at both measurement sites. The highest correlations between Observer 1 (OB1) and Observer 2 (OB2) with least differences in measurements were with the stifle in the extended position. Agreement between two observers using standard measuring technique was significant at both the 50% (OB1: 34.10 ± 2.93 cm, OB2: 34.08 ± 2.65 cm, P = 0.007, ICC = 0.984) and 70% (OB1: 29.89 ± 2.43 cm, OB2: 30.04 ± 2.30 cm, P = 0.004, ICC = 0.981) TL positions with the stifle placed in extended position.Conclusion and Clinical Importance: Thigh girth measurement may be useful as an outcome measure when appropriate measuring technique is used. It is recommended that thigh girth be obtained at a distance of 70% thigh length, with the leg in an extended position while in lateral recumbency, and the dog relaxed or under sedation. Further studies should be performed in a variety of clinical situations.

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Results of Arthroscopic Versus Open Arthrotomy for Surgical Management of Cranial Cruciate Ligament Deficiency in Dogs

Abstract: The results of this study suggest that short-term postoperative morbidity may be reduced in dogs receiving arthroscopic joint surgery with a limited approach for stifle stabilization as compared with a traditional open arthrotomy technique.

Cited by 99 publications

References 24 publications

Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Glucosamine and chondroitin sulfate in the repair of osteochondral defects in dogs - clinical-radiographic analysis

Variables Affecting Thigh Girth Measurement and Observer Reliability in Dogs

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