Introduction: Osteoarthritis of knee joint is the most common form of arthritis, affecting a huge population of about 237 million (3.3% of the population). Among those over 60 years old, about 10% of males and 18% of females are affected. Medial compartment is a common disease, caused by additional force on the medial compartment as a result of varus malalignment. The high tibial osteotomy (HTO) is one possibility for the treatment of varus gonarthrosis. Especially for younger and active patients this method can produce long-term relief, which often significantly delays the need for knee arthroplasty. Various techniques for valgus HTOs are described. High tibial osteotomy (HTO) is a widely performed procedure to treat medial knee arthrosis. Materials and Methods: This was a prospective study of 30 patients in the age group between 50 years and 70 years of medial compartment osteoarthritis of knee joint treated by opening wedge osteotomy fixed with orthofix and puddu plate. The study was conducted in the Department of Orthopaedics, SRMS IMS, Bareilly in between September 2016 to march 2018.Patients were randomly allocated in two groups by a computer generated selection system. Their functional results were analysed using knee soceity score. Results: Statistical analysis was performed to compare the demographic characteristics between two groups. The groups were compared with regards to age and sex, grade of osteoarthritis, time of consolidation and functional outcome. Majority of patients were males accounting to 73.33% n=22). Mean age of patients was 61.5years. Minimum age in this series was 52 years and maximum age in this series was 70 years. An unilateral Osteotomy was done in a single setting even when bilateral procedures were required. In our study bilateral osteotomy was done in 12 (40%) patients out of 30 patients. 18 Patients were treated unilaterally (60%).Among unilaterally treated patients majority of these were treated on right knee. Conclusion: Shorter follow-up period is the main shortcoming of our study. However, early results obtained indicate that medial open-wedge osteotomies in medial compartment osteoarthritis of knee fixed using Puddu plates and ortho fix could be done safely and effectively with considerable success with encouraging outcomes, and this technique could be a good alternative for unicompartmental total knee arthroplasty.