Results of human experiments with typhoid-chrome-vaccine

Chrome typhoid vaccine

“…They considered the possession of the Vi-antigen and the production of Vi-antibodies to be of much importance in gauging the efficacy of typhoid vaccines, which is a reasonable view based on the observed facts that the Vi-antibody is certainly found in patients and carriers of typhoid bacilli, and bacilli isolated from patients contain this antigen (Bhatnagar, 1938;Bhatnagar, Speechley & Singh, 1938;Felix, Kirkorian & Reitler, 1935). Kaneko, Hajashi, Hiraj & Ando (1953) compared a chrome vaccine with a heated typhoid-paratyphoid vaccine and stated, 'The Vi-antibody in sera may be considered insufficient to be the direct proof of the protective immunity against the typhoid fever, but its presence should be related to some extent to the typhoid immunization and it is supposed that the chrome vaccine is the superior one for the typhoid immunization conferring higher Vi serum titres. '…”