Results of immunohistochemical staining for cell cycle regulators predict the recurrence of atypical meningiomas

Kim, Min Soo; Kim, Kyu Hong; Lee, Eun Hee; Lee, Young Min; Lee, Sunghun; Kim, Hyung Dong; Kim, Young Zoon

doi:10.3171/2014.7.jns132661

Cited by 38 publications

(41 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean follow-up time in 80 patients was 4 years (range 6 months to 10.5 years). The results are similar to data previously published in the literature describing from 26 ( 17 ) to 120 ( 23 ) patients followed for a period of 8 months ( 24 ) to 21 years ( 23 ).…”

Section: Discussionsupporting

confidence: 90%

Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence

Trott

Pereira-Lima

Leães

et al. 2015

Braz J Med Biol Res

View full text Add to dashboard Cite

Meningiomas are common, usually benign tumors, with a high postoperative recurrence rate. However, the genesis and development of these tumors remain controversial. We aimed to investigate the presence and implications of a mutated p53 protein and dopamine D2 receptor in a representative series of meningiomas and to correlate these findings with age, gender, tumor grade, and recurrence. Tumor tissue samples of 157 patients diagnosed with meningioma (37 males and 120 females, mean age 53.6±14.3 years) who underwent surgical resection between 2003 and 2012 at our institution were immunohistochemically evaluated for the presence of p53 protein and dopamine D2 receptor and were followed-up to analyze tumor recurrence or regrowth. Tumors were classified as grades I (n=141, 89.8%), II (n=13, 8.3%), or grade III (n=3, 1.9%). Dopamine D2 receptor and p53 protein expression were positive in 93.6% and 49.7% of the cases, respectively. Neither of the markers showed significant expression differences among different tumor grades or recurrence or regrowth statuses. Our findings highlight the potential role of p53 protein in meningioma development and/or progression. The high positivity of dopamine D2 receptor observed in this study warrants further investigation of the therapeutic potential of dopamine agonists in the evolution of meningiomas.

show abstract

Section: Discussionsupporting

confidence: 90%

Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence

Trott

Pereira-Lima

Leães

et al. 2015

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…Cyclin D1 and CDK4, cell cycle proteins, can form a complex known as Cyclin D1/CDK4 to drive cells through the cell cycle G1/S checkpoint to initiate activation (Kim et al, 2014;Liu et al, 2018). We found that curcumin exposure increased the expression of CDK4 and Cyclin D1 protein significantly, and the expression of CDK4 and Cyclin D1 induced by curcumin was relieved by DAPT treatment, which was consistent with the result of BrdU/Nestin, Notch1, and Hes1 protein.…”

Section: Figsupporting

confidence: 79%

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Li¹,

Han²,

et al. 2019

Cellular Reprogramming

View full text Add to dashboard Cite

The abnormal deposition of amyloid-b peptide, a major component of senile plaques, has been reported to be the major cause of neuronal cell death and cognitive impairment in Alzheimer's disease (AD). Adult neurogenesis is related to the amelioration of impaired neurons and cognitive impairment. In the research, we investigated the function of curcumin on endogenous neural stem cells (NSCs) and hippocampal neurogenesis in mice. APP/PS1 transgenic mice as animal models were treated with curcumin, and a significant improvement in learning and memory function was observed. The improvement was associated with a significant increase in the number of new neural stem cells (BrdU + /Nestin +) and newborn neurons (NeuN/kI67 +) in the hippocampal region and decreased the number of apoptotic neurons (TUNEL + and Caspase-3/NeuN +). These results suggested that curcumin activated NSCs proliferation, improved neurogenesis, and ameliorated cognitive impairment of AD mice. Then, we identified that curcumin upregulated the expression of self-renewal genes, Notch1 and Hes1, and augmentation of CDK4, Cyclin D1, NICD, and Hes1 protein. As Notch activity was blocked by the DAPT, the related proteins were downregulated, and the initiating cell proliferation of curcumin was abolished. These results might suggest that the function of curcumin was dependent on Notch signaling pathway.

show abstract

“…As regards the extent of resection, which is a significant independent predictive factor of recurrence in atypical meningiomas as well as in meningiomas overall, many authors have reported similar results. As published previously (the data was not presented in this article), the results in the present study-those obtained through Kaplan-Meier survival analysis and the Cox proportionalhazards regression model-correspond well with these findings, suggesting that the most important factor in determining the likelihood of meningioma recurrence is the extent of tumor resection [51]. However, in this study, postoperative radiotherapy was not an independent factor predicting the recurrence of atypical meningiomas in the multivariate analysis (Cox proportional-hazards regression model), and it showed only a tendency to predict a recurrence (p=0.058) [51].…”

Section: Journal Of Clinical Epigeneticssupporting

confidence: 80%

Dysregulation of Apoptosis Caused by Aberrant Histone Modification Influences on the Recurrence of Meningiomas

Kim¹

2017

J Clin Epigenet

View full text Add to dashboard Cite

Background: Alteration of apoptosis is related with progression and recurrence of atypical meningiomas (AMs). However, no comprehensive study has been conducted regarding histone modification regulating apoptosis in AMs. This study was aimed to determine the prognostic values of certain apoptosis-associated factors, and examine the role of histone modification on apoptosis in AMs. Materials and method:The medical records of 67 patients with AMs, as diagnosed during recent 13 years, were reviewed retrospectively. Immunohistochemical staining was performed on archived paraffin-embedded tissues for pro-apoptotic factors (CASP3, IGFBP, TRAIL-R1, BAX, and XAF1), anti-apoptotic factors (survivin, ERK, RAF1, MDM2, and BCL2), and the histone modifying enzymes (MLL2, RIZ, EZH1, NSD2, KDM5c, JMJD2a, UTX, and JMJD5).Results: Twenty-six (38.8%) patients recurred during the follow-up period (mean duration 47.7 months). In terms of time-to-recurrence (TTR), overexpression of CASP3, TRAIL-R1, and BAX had a longer TTR than underexpression, and overexpression of Survivin, MDM2, and BCL2 had a shorter TTR than underexpression (P<0.05). Additionally, overexpression of MLL2, UTX, and JMJ5 had shorter TTRs than underexpression, and overexpression of KDM5c had a longer TTR than underexpression. However, in the multi-variate analysis of predicting factors for recurrence, underexpression of CASP3 (P<0.001), and BAX (P<0.001), and overexpression of survivin (P=0.007), and MDM2 (P=0.037) were associated with recurrence independently, but any enzymes modifying histone were not associated with recurrence. Conclusion:This study suggests certain apoptosis-associated factors should be associated with recurrence of AMs, which may be regulated epigenetically by histone modifying enzymes.Keywords: Atypical meningioma; Apoptosis; Histone modification; Recurrence; Epigenetics a low recurrence rate after gross total resection (GTR) [5,6]. series have included only a few patients [9,10]. Even after GTR, tumor recurrence is observed after several years in some 20 to 30% of cases [11,12]. Thus, a reasonable organized therapeutic strategy could be instituted if recurrence could be predicted from surgical specimens, and for this reason many authors have investigated the histological indices of proliferative and apoptotic potential in resected AMs, such as, BCL2 [13,14], proliferating cell nuclear antigen [13], and Ki-67 cell cycle-specific nuclear antigen [15,16]. From these indices, researchers have attempted to establish the nature of the relationship between histological aggressiveness and the recurrence of AMs.

show abstract

Results of immunohistochemical staining for cell cycle regulators predict the recurrence of atypical meningiomas

Cited by 38 publications

References 50 publications

Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence

Abundant immunohistochemical expression of dopamine D2 receptor and p53 protein in meningiomas: follow-up, relation to gender, age, tumor grade, and recurrence

Curcumin Promotes Proliferation of Adult Neural Stem Cells and the Birth of Neurons in Alzheimer's Disease Mice via Notch Signaling Pathway

Dysregulation of Apoptosis Caused by Aberrant Histone Modification Influences on the Recurrence of Meningiomas

Contact Info

Product

Resources

About