Results of Laboratory Monitoring in Patients Taking Isotretinoin for Acne

Al-Haddab, Mohammed; Alhuqayl, Alanoud; Alsharif, Heba M.; Alolyet, Dana; AlTaleb, Rawan Murshed

doi:10.12788/cutis.0291

Cited by 5 publications

(6 citation statements)

References 10 publications

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“… 10 In contrast, Al Riyadh, KSA study demonstrated high TG levels over time (1.6%, 3.8%, and 4.4%) at baseline and first and second readings, respectively. 14 Another retrospective study of 415 patients also supported significant differences between TG measurements mostly between the second month (23.9%) and the fourth month (27.2%). 16 Many studies supported that high TG levels were associated with the third and sixth months of treatment.…”

Section: Discussionmentioning

confidence: 76%

“…10 On the other hand, a retrospective study in Al Riyadh, KSA of 386 patients had high TC baseline readings as well as 2 follow-up readings (12.1%, 21.8%, and 18.7%, respectively). 14 Also, a study done in Sakarya University, Turkey, found no relation statistically between the third and sixth months of treatment in all parameters including cholesterol and TG. 15 Regarding triglyceride level readings, we noticed that almost all the patients had a normal baseline (90.9%) and both second (95.5%) and last (94.3%) follow-up readings.…”

mentioning

confidence: 92%

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Isotretinoin-Induced Dyslipidemia: a Single-Center Study in Saudi Arabia

Al Dhafiri,

Kaliyadan,

Almukhaimar

et al. 2024

PPA

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Purpose Acne is a chronic inflammatory skin disease with a high prevalence in Saudi Arabia. Isotretinoin is used to treat severe, resistant nodulocystic acne. Side effects include joint discomfort, headache, mucosal dryness, and nose bleeds. Elevated lipids and liver enzymes have also been recorded. The study goal is to identify the prevalence of increased lipid levels during and after isotretinoin use. Patients and Methods This retrospective study was conducted in the dermatology polyclinic at King Faisal University, Al-Ahsa, Saudi Arabia. It included adults of different age groups diagnosed with acne vulgaris and treated with oral isotretinoin between January 2021 and December 2022. Parameters included baseline laboratory tests and follow-up laboratory results of cholesterol and triglycerides. Results Among 88 patients, 48.9% were aged 21–23 years, with females dominating. In total, 47.7% of patients started using isotretinoin at age 20 years or less, with starting doses ranging from 10 to 20 mg. Fifty percent of the patients had five months or more of treatment duration and only 6.8% of the patients had previously used isotretinoin. For the cholesterol and triglycerides, 87.5% of patients had normal pre-treatment with cholesterol and 90.9% with triglycerides, followed by 81.8% and 95.5% in the second reading, respectively. In the last reading, results were 77.3% for cholesterol and 94.3% for triglycerides. Conclusion The study found that most acne patients treated with isotretinoin had normal cholesterol and triglyceride levels at baseline, second, and last readings. The incidence of higher laboratory alterations was low, with 12.5% and 4.5% for cholesterol and triglycerides at baseline, and 18.2% and 3.4% at second, and 22.7% and 5.7% at last readings. Overall, age, gender, age of start of isotretinoin, isotretinoin dose, and previous use of isotretinoin are factors that could affect laboratory readings.

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Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 92%

Isotretinoin-Induced Dyslipidemia: a Single-Center Study in Saudi Arabia

Al Dhafiri,

Kaliyadan,

Almukhaimar

et al. 2024

PPA

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“…Aunque el perfil de seguridad de la isotretinoina para el tratamiento de acné pareciera ser difícil (4) de sopesar , realmente la evidencia científica y recomendaciones de expertos sugieren que el monitoreo continuo no es útil, basados en que predominantemente solo los triglicéridos y pruebas de función hepática sufren alteraciones, pero estos se presentan en un porcentaje muy bajo de pacientes y no representan un riesgo considerable. Por el contrario, es necesario pensar en realizar intervenciones utilizando el mínimo de recursos, sobre todo en países de bajos y medianos ingresos, donde los sistemas de salud presentan numerosas barreras para garantizar acceso oportuno y eficaz a terapias especializadas.…”

Section: Estimado Editorunclassified

Monitoreo de laboratorio en pacientes bajo tratamiento con isotretinoina: ¿es necesario realizarlo de forma continua?

Jaimes

López

Guevara

et al. 2023

Rev. virtual Soc. Parag. Med. Int.

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“…Results of retrospective study in 2021 concluded that changes in serum transaminase and lipid profiles are unlikely to occur when isotretinoin is used. However, physicians should be cautious when prescribing isotretinoin to individuals who have a history of aberrant results [22].…”

Section: Monitoring Of Isotretinoinmentioning

confidence: 99%

Indication, Contraindication, Complication and Monitoring of Isotretinoin

Alyamani

Alharbi²,

Alghamdi³

et al. 2022

JPRI

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Acne is the most prevalent skin disorder affecting primarily adolescents and young adults. Side effects of acne, such as scarring, dyspigmentation, and low self-esteem, can cause severe morbidity. Isotretinoin is a medication that is used to treat severe acne. The medicine was licensed by the Food and Drug Administration in 1982 to treat severe nodular acne that had been resistant to other treatments, including systemic antibiotics. Other indications of isotretinoin include moderate acne, cutaneous T-cell lymphomas, neuroblastoma, and the prevention of squamous cell carcinoma in high-risk patients. Rosacea, folliculitis, and pyoderma faciale have all been treated with isotretinoin. Some side effects are also associated with the use of isotretinoin including teratogenicity the most severe one. The purpose of this research is to review the available information about indication, contraindication, complication and monitoring of Isotretinoin. Various dermatological conditions are also treated with isotretinoin apart from the common indication of acne. Complete blood count along with the lipid profile, and liver function test are monitored in patients on isotretinoin therapy. Dry lips and dry skin are among the common side effects of isotretinoin. Due to the severe complication of teratogenicity isotretinoin is contraindicated among pregnant women. Evidence from the literature suggests that isotretinoin is the effective medication in treatment of acne and low dose of isotretinoin does not cause any complication. Evidence-based guidelines and strategies for safety and efficacy of isotretinoin can be developed by further clinical research and trials.

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Results of Laboratory Monitoring in Patients Taking Isotretinoin for Acne

Cited by 5 publications

References 10 publications

Isotretinoin-Induced Dyslipidemia: a Single-Center Study in Saudi Arabia

Isotretinoin-Induced Dyslipidemia: a Single-Center Study in Saudi Arabia

Monitoreo de laboratorio en pacientes bajo tratamiento con isotretinoina: ¿es necesario realizarlo de forma continua?

Indication, Contraindication, Complication and Monitoring of Isotretinoin

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