Results of monoclonal antibodies against EGFR-receptors application in patients with metastatic colorectal cancer (mCRC).

Vladimirova, Liubov Yu; Никипелова, Е. А.; Abramova, Natalya A

doi:10.1200/jco.2013.31.15_suppl.e14701

Cited by 2 publications

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“…таким образом, воспаление влияет на все аспекты развития опухоли и может также повлиять на эффективность лечения рака [58]. Противовоспалительные препараты могут снизить риск Крр; клинические испытания, возможно, покажут терапевтическую эффективность противовоспалительных биопрепаратов, таких как анти-TNF, анти-IL-6, анти-IL-1 и ингибиторы NF-kB и STAT3.…”

Section: Bacterоides Fragilisunclassified

Inflammation and Colon Cancer. Molecular and Immunological Mechanisms

Никипелова¹,

Шапошников²,

Златник³

et al. 2018

Problems in oncology

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After the analysis of data presented in the international literature there are still a lot of controversial issues on the impact of inflammation on the development of colon cancer. Molecular mechanisms of various types of colorectal cancer are different and connected with inflammatory bowel diseases. There are some immunological similarities and differences between colitis-associated colon cancer occurring in inflammation and other types of colorectal cancer developing without any signs of inflammatory process. The gut microbiota significantly influences on the development of sporadic colorectal cancer and colitis-associated cancer. Malignant colon tumors, without dependence on the colorectal cancer type, have an increased expression of pro-inflammatory cytokines. The role of tumor-infiltrating immunocytes and tumor inflammatory microenvironment in colorectal cancer is complex: they are involved in antitumor immune defense and play a pro-oncogenic role. In perspective anti-inflammatory biologic drugs are expected to decrease the risk of the development of colorectal cancer.

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Section: Bacterоides Fragilisunclassified

Inflammation and Colon Cancer. Molecular and Immunological Mechanisms

Никипелова¹,

Шапошников²,

Златник³

et al. 2018

Problems in oncology

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Influence of copper nanoparticles on the growth characteristics of tumors in white outbreed rats

Качесова¹,

Goroshinskaya²,

Zhukova³

et al. 2022

Issled. prakt. med. (Print)

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Purpose of the study. To study the effect of copper nanoparticles on the characteristics of the transplanted tumors of rats, as well as to assess the dependence of the effect on the method of administration of nanoparticles.Materials and methods. In experiments on 163 white outbred male rats, 160–200 g, the size and growth rate of transplanted sarcoma 45 and Pliss' lymphosarcoma were determined in dynamics when a suspension of copper nanoparticles in physiological saline was injected intratumorally or intraperitoneally in a total dose of 10 mg/kg. Nanoparticles had a "core-shell" structure with variable diameter in the range of 30–75 nm. Contrary to other researches, we started the exposure to metal nanoparticles only when the tumors had become visible and had grown up to the sizes at which their spontaneous regression was unlikely.Results. In most animals (up to 89 %), significant antitumor effects of copper nanoparticles were obtained up to complete regression of tumors with large volumes. The effects of nanodispersed copper differed in tumors with different histological structures and growth patterns. Experiments on a transplantable, slowly growing sarcoma 45 showed a decrease in the specific tumor growth rate after a single injection of nanoparticles (1.25 mg/kg), a decrease in tumor size could be observed after 4 injections (a total dose of 5 mg/kg). In the case of a rapidly growing tumor model (Pliss' lymphosarcoma), a decrease in tumor growth rates caused by copper nanoparticles occurred at later stages of exposure, after the animals received nanoparticles at a total dose of 5–10 mg/kg. The efficiency depended on the approach of nanoparticles injection.Conclusion. In case of sarcoma 45, intraperitoneal injection of copper nanoparticles was more effective than intratumoral one, while in rats with Pliss' lymphosarcoma intratumoral injection of the nanoparticles had some advantages. The results indicate that nanodispersed copper is a promising antitumor factor. The mechanisms of regression of large transplanted tumors under the influence of copper nanoparticles are discussed.

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Results of monoclonal antibodies against EGFR-receptors application in patients with metastatic colorectal cancer (mCRC).

Cited by 2 publications

References 0 publications

Inflammation and Colon Cancer. Molecular and Immunological Mechanisms

Inflammation and Colon Cancer. Molecular and Immunological Mechanisms

Influence of copper nanoparticles on the growth characteristics of tumors in white outbreed rats

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