Results of native and transplant kidney biopsies of children in a single center over a 15 years period

Abstract

Renal biopsy is an important diagnostic procedure in pediatric nephrology. This study retrospectively investigates the indications, results and complications in a single tertiary children's hospital in Turkey. We evaluated the native and transplant kidney biopsies in Gazi University Pediatric Nephrology Department between 2001 and 2015. A total of 196 biopsies (144 natives and 52 transplants) were included into the study. The mean age of the patients was respectively 10.8 ± 3.5, 13.9 ± 1.5 years. The main indication for a biopsy was non-nephrotic proteinuria with or without hematuria (n¼ 35), followed by steroid-resistance nephrotic syndrome (SRNS) (n ¼ 34) and Henoch-Sch€ onlein purpura (HSP)-related proteinuria (n ¼ 20) for native kidneys. We found that focal segmental glomerulosclerosis (FSGS) (11.7%) was the most common histopathologic diagnosis for native kidneys, but acute cellular rejection (7.6%) was the most common histopathologic diagnosis for transplant kidneys. The complication rate in our study was founded 6.6% totally. Different complication rates were found in other studies; however, we think that this difference comes from the inspecting methodology of the complications. Hence, we wanted to share our own experience in the context of other studies in the literature. ARTICLE HISTORY

Spectrum of histopathological findings in pediatric renal biopsies; a five-year single center experience in Egypt

“…One of the C3 glomerulopathy cases showed FSGS pattern (Figure 8), and another one with dense deposits had almost normal appearance by light microscopy (Figure 9). while IgA nephropathy/Henoch-Schoenlein purpura were dominant in European reports from Italy, Portugal and UK (2,3,15), and FSGS in studies from Turkey (7,17) and Serbia (18). In our study, a major proportion of the patients had congenital glomerular diseases (22.41%) that is potentially related to the high incidence of consanguineous marriages in Egyptian population.…”

“…Only one case of amyloidosis was encountered secondary to familial Mediterranean fever and showed glomerular deposits without other vascular or tubulointerstitial affection. This very low incidence of renal amyloidosis in children is also noticed in other Mediterranean countries' reports (2,7). This study is limited by lack of performing genetic study for the unclassified histological patterns of GBM abnormalities.…”

“…The prevalence and patterns of medical renal diseases in this age group are variable among different ethnic population. Data are published based on studies of renal biopsy specimens from different countries (2)(3)(4)(5)(6)(7)(8)(9); however, those available from African/Arab countries are lacking with few published reports (10,11). Renal diseases, in particular those progressing to end-stage kidney disease (ESKD) have a well-established indirect impact on global morbidity and mortality by increasing the risks associated with cardiovascular diseases, diabetes mellitus, hypertension and various infections.…”