Results of Oncothermia Combined with Operation, Chemotherapy and Radiation Therapy for Primary, Recurrent and Metastatic Sarcoma

Jeung, Tae Sig; Young, Sun; Choi, Ji‐Hoon; Yu, Jeasang; Lee, Su Yong; Lim, Sangwook

doi:10.4236/crcm.2015.45033

Cited by 15 publications

(6 citation statements)

References 26 publications

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“…Patients with penile fibrosis (Peyronie's disease) (146), and palm fibrosis (Dupuytren's contracture) (147) were successfully treated with mEHT. Furthermore, the mEHT treatment on malignant fibrosarcoma also showed a great benefit for the patient (148). The mEHT is successfully applied as a complementary treatment for lung cancer with high-dose vitamin C (149).…”

Section: Treatment Of Fibrosismentioning

confidence: 98%

A Potential Bioelectromagnetic Method to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19

Masaud¹,

Szász²,

Szász³

et al. 2020

Front. Immunol.

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IntroductionRight now, we are facing a global pandemic caused by the coronavirus SARS-CoV-2 that causes the highly contagious human disease COVID-19. The number of COVID-19 cases is increasing at an alarming rate, more and more people suffer from it, and the death toll is on the rise since December 2019, when COVID-19 has presumably appeared. We need an urgent solution for the prevention, treatment, and recovery of the involved patients.MethodsModulated electro-hyperthermia (mEHT) is known as an immuno-supportive therapy in oncology. Our proposal is to apply this method to prevent the progression of the disease after its identification, to provide treatment when necessary, and deliver rehabilitation to diminish the fibrotic—often fatal—consequences of the infection.HypothesisThe effects of mEHT, which are proven for oncological applications, could be utilized for the inactivation of the virus or for treating the fibrotic consequences. The hypothesized mEHT effects, which could have a role in the antiviral treatment, it could be applied for viral-specific immune-activation and for anti-fibrotic treatments.

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Section: Treatment Of Fibrosismentioning

confidence: 98%

A Potential Bioelectromagnetic Method to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19

Masaud¹,

Szász²,

Szász³

et al. 2020

Front. Immunol.

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“…The primary leiomyosarcoma of the breast following salvage mEHT and pazopanib, as well as recurrent metastatic sarcoma, indicates the applicability of the method in this type of solid tumors, which was proven in more cases, and in clinical trial too [91][92][93]. The advantages of the complex approach are shown by an 8-year observational study for the survival time of various advanced solid tumors treated complementarily by mEHT, as well as for various malignant diseases when mEHT was applied independently [94,95].…”

Section: Discussionmentioning

confidence: 99%

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Szász¹

2020

COR

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Hyperthermia treatment for solid tumors is a long-used, but poorly accepted method in clinical use. Modulated electro-hyperthermia (mEHT, trade name: oncothermia®) changes the paradigm, introduces a novel, cellularly selective and immunogenic cell-ruination. The mEHT method produces tumor-vaccination, presenting the unharmed genetic information of cancer cells to immune cells [1]. The mEHT method is approved in more than 30 countries. Its phase II/III clinical applications indicate a broad perspective.

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“…The research culminated in a large ( n = 341) phase III randomized controlled trial ( 362 ) showing a 29.2% risk reduction (after 5.7 years median follow-up) in local progression or death when lesions were treated with loco-regional hyperthermia combined with surgery and radiotherapy. Some characteristic case reports ( 363 ) and a phase II clinical trial were also published with mEHT ( 364 ).…”

Section: Effects Of Hyperthermiamentioning

confidence: 99%

Quo Vadis Oncological Hyperthermia (2020)?

et al. 2020

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Heating as a medical intervention in cancer treatment is an ancient approach, but effective deep heating techniques are lacking in modern practice. The use of electromagnetic interactions has enabled the development of more reliable localregional hyperthermia (LRHT) techniques whole-body hyperthermia (WBH) techniques. Contrary to the relatively simple physical-physiological concepts behind hyperthermia, its development was not steady, and it has gone through periods of failures and renewals with mixed views on the benefits of heating seen in the medical community over the decades. In this review we study in detail the various techniques currently available and describe challenges and trends of oncological hyperthermia from a new perspective. Our aim is to describe what we believe to be a new and effective approach to oncologic hyperthermia, and a change in the paradigm of dosing. Physiological limits restrict the application of WBH which has moved toward the mild temperature range, targeting immune support. LRHT does not have a temperature limit in the tumor (which can be burned out in extreme conditions) but a trend has started toward milder temperatures with immune-oriented goals, developing toward immune modulation, and especially toward tumor-specific immune reactions by which LRHT seeks to target the malignancy systemically. The emerging research of bystander and abscopal effects, in both laboratory investigations and clinical applications, has been intensified. Our present review summarizes the methods and results, and discusses the trends of hyperthermia in oncology.

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Results of Oncothermia Combined with Operation, Chemotherapy and Radiation Therapy for Primary, Recurrent and Metastatic Sarcoma

Cited by 15 publications

References 26 publications

A Potential Bioelectromagnetic Method to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19

A Potential Bioelectromagnetic Method to Slow Down the Progression and Prevent the Development of Ultimate Pulmonary Fibrosis by COVID-19

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Quo Vadis Oncological Hyperthermia (2020)?

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