Abstract-The Bosumtwi impact structure of central Ghana was drilled in 2004 as part of the International Continental Scientific Drilling Program (ICDP). A vast amount of geoscience data is available from the pre-site surveys and the actual drilling phase. A 3-D gravity model was constructed and calibrated with the available data from the two ICDP boreholes, LB-07A and LB-08A. The 3-D gravity model results agree well with both the sediment thickness and size of the central uplift revealed by previously collected seismic data, and with the petrophysical data from the LB-08A and LB-07A core materials and the two borehole logs. Furthermore, the model exhibits lateral density variations across the structure and refines the results from previous 2.5-D modeling. An important new element of the 3-D model is that the thickness of the intervals comprising polymict lithic impact breccia and suevite, monomict lithic breccia and fractured basement is much smaller than that predicted by numerical modeling.