Results of salvage abdominoperineal resection for anal cancer after radiotherapy

Abstract

Salvage abdominoperineal resection for anal cancer can be expected to yield a number of survivors from residual disease, but the low rate of survival after abdominoperineal resection for recurrent disease suggests the need for additional postoperative treatment if salvage abdominoperineal resection is performed.

Surgical salvage therapy of anal canal cancer

“…Earlier investigators reported the perineal wound complication rate was up to 30% [16,17,21] . In the study by Nilsson et al [22] , the rate of delayed healing was 66 % (22 of 35).…”

“…Surgical resection was often recommended as the most appropriate salvage method [13][14][15] . The overall survival rate for surgical salvage at 5 years was about 30-60% [16,17] . Some investigators reported disappointingly low success rates [18] and alternative approaches have been suggested, such as low dose radiotherapy or combined chemoradiotherapy [19] .…”

Carcinoma of the Anus: Strategies in Management

“…Others with larger residual disease receive salvage APR. The overall survival data for surgical salvage at 5 years is about 30%-60% [77,78]. Some use, as an option, a repeat combined chemoradiation treatment for salvage purposes, with comparable success.…”

Resultados do tratamento do carcinoma espinocelular anal e do seu precursor em doentes HIV-positivos

“…O tratamento operatório é necessário para ressecar o tumor rema- nescente em caso de falência da terapia inicial, o que ocorre em 10% a 15% das vezes, sendo a amputação abdominoperineal o procedimento mais realizado [44][45][46] . A radio e quimioterapia falhou em apenas um dos nossos doentes (11,2%).…”