Results of Screening Colonoscopy among Persons 40 to 49 Years of Age

Imperiale, Thomas F.; Wagner, David R.; Lin, Ching Yih; Larkin, Gregory N.; Rogge, James D.; Ransohoff, David F.

doi:10.1056/nejm200206063462304

Cited by 316 publications

(230 citation statements)

References 21 publications

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“…In einer prospektiven Koloskopiestudie zeigte sich eine deutlich niedrigere Nachweisrate fortgeschrittener Adenome bei 40-bis 49-Jährigen (3,5 %) [94]. Von großer Bedeutung ist die Identifikation von Personen mit erhöhtem KRK-Risiko, für die gesonderte Empfehlungen gelten (siehe Kapitel 5).…”

Section: Starker Konsensunclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

151

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Section: Starker Konsensunclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

151

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“…In a previous study of 906 persons aged 40 to 49 years who underwent first-time screening colonoscopy, no cancers were discovered (upper 95% CI of 0.4%) [5]. Further, advanced neoplasia 1 was uncommon and tended to be distal to the splenic flexure.…”

Section: Introductionmentioning

confidence: 86%

Risk factors for advanced sporadic colorectal neoplasia in persons younger than age 50

Imperiale

Kahi

Stuart

et al. 2008

Cancer Detection and Prevention

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Background-Colorectal cancer (CRC) screening is recommended for average risk adults beginning at age 50. However, 7% of CRC occurs in persons younger than age 50, a group for which risk factors are not well defined. We sought to determine whether a retrospective case-control study could identify risk factors for sporadic CRC and advanced adenomatous polyps (together known as sporadic colorectal neoplasia [CRN]).

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“…The model output was QALY. We discounted costs and effects at 5% annually and used a half-cycle correction to account for these discounts (Imperiale et al, 2010). DOI:http://dx.doi.org/10.7314/APJCP.2012.13.10 …”

Section: Markov Model In This Studymentioning

confidence: 99%

Markov's Modeling for Screening Strategies for Colorectal Cancer

Barouni

Larizadeh²,

Sabermahani³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Economic decision models are being increasingly used to assess medical interventions. Advances in this field are mainly due to enhanced processing capacity of computers, availability of specific software to perform the necessary tasks, and refined mathematical techniques. We here estimated the incremental cost-effectiveness of ten strategies for colon cancer screening, as well as no screening, incorporating quality of life, noncompliance and data on the costs and profit of chemotherapy in Iran. We used a Markov model to measure the costs and quality-adjusted life expectancy of a 50-year-old average-risk Iranian without screening and with screening by each test. In this paper, we tested the model with data from the Ministry of Health and published literature. We considered costs from the perspective of a health insurance organization, with inflation to 2011, the Iranian Rial being converted into US dollars. We focused on three tests for the 10 strategies considered currently being used for population screening in some Iranians provinces (Kerman, Golestan Mazandaran, Ardabil, and Tehran): low-sensitivity guaiac fecal occult blood test, performed annually; fecal immunochemical test, performed annually; and colonoscopy, performed every 10 years. These strategies reduced the incidence of colorectal cancer by 39%, 60% and 76%, and mortality by 50%, 69% and 78%, respectively, compared with no screening. These approaches generated ICER (incremental cost-effectiveness ratios) of $9067, $654 and $8700 per QALY (quality-adjusted life year), respectively. Sensitivity analyses were conducted to assess the influence of various scales on the economic evaluation of screening. The results were sensitive to probabilistic sensitivity analysis. Colonoscopy every ten years yielded the greatest net health value. Screening for colon cancer is economical and cost-effective over conventional levels of WTP8.

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Results of Screening Colonoscopy among Persons 40 to 49 Years of Age

Cited by 316 publications

References 21 publications

S3-Leitlinie – Kolorektales Karzinom

S3-Leitlinie – Kolorektales Karzinom

Risk factors for advanced sporadic colorectal neoplasia in persons younger than age 50

Markov's Modeling for Screening Strategies for Colorectal Cancer

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