Results of shared learning of a new magnetic seed localisation device – A UK iBRA-NET breast cancer localisation study

Morgan, Jenna; Bromley, Hannah L.; Dave, Rajiv; Masannat, Yazan; Masudi, Tahir; Mylvaganam, Senthurun; Elgammal, Suzanne; Barnes, Nicola; Down, Sue; Holcombe, Chris; Potter, Shelley; Gardiner, Matthew; Maxwell, Anthony; Somasundaram, Santosh K.; Sami, Amtul; Kirwan, Cliona C.; Harvey, James

doi:10.1016/j.ejso.2022.07.014

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…The implementation of non-wire localization techniques allowed more efficient use of radiology resources. To evaluate these new techniques allowing localization of impalpable breast lesions, a National UK group collects all data from units in the United Kingdom through the iBRA-NET study (30)(31)(32). This will allow large scale evaluation of clinical outcomes, ensuring device safety and efficacy, to define new guidelines for pre-operative detection of subclinical breast lesions.…”

Section: Discussionmentioning

confidence: 99%

Clinical experience of the Magseed® magnetic marker to localize non-palpable breast lesions: a cohort study of 100 consecutive cases

Crèvecoeur¹,

Jossa²,

Bella³

et al. 2023

Gland Surg

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Background: The aim of this study was to report on a cohort of 100 patients where the Magseed ® paramagnetic marker was used to localize non-palpable breast lesions.Methods: Data was collected from a cohort of 100 patients with non-palpable breast lesions, who underwent localization using the Magseed ® marker. This marker consists of a paramagnetic seed that can be seen on mammography or ultrasound and intraoperatively detected with the use of the Sentimag ® probe.The data were collected over a period of 23 months (May 2019 to April 2021).Results: All 111 seeds were successfully placed in the breasts of 100 patients under ultrasound or via stereotactic guidance. Eighty-nine seeds were inserted in single lesions or small microcalcification clusters in a single breast, 12 seeds were deployed to a bracket microcalcification clusters and 10 to help localize two tumors within the same breast. Most Magseed ® markers (88.3%) were placed in the center of the lesion (≤1 mm). The re-excision rate was 5%. All Magseed ® markers were successfully retrieved and no surgical complications were observed.Conclusions: This study reports our experience in a Belgian breast unit using the Magseed ® magnetic marker and it highlights the many advantages of the Magseed ® marker system. With this system, we successfully identified subclinical breast lesions and extended microcalcification clusters, targeting multiple sites within the same breast.

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Section: Discussionmentioning

confidence: 99%

Clinical experience of the Magseed® magnetic marker to localize non-palpable breast lesions: a cohort study of 100 consecutive cases

Crèvecoeur¹,

Jossa²,

Bella³

et al. 2023

Gland Surg

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“…The use of Magseed did not only achieve smaller specimens but also resulted in higher patient and physician satisfaction, and thus a preference for the magnetic technique [60]. Magseed localization is compromised by metal instruments and can be challenging when the seed is placed deep in the breast [61]. There is no evidence for superior cost-effectiveness or patient-reported outcomes when comparing it to other localization devices [62].…”

Section: Magnetic and Paramagnetic Localizationmentioning

confidence: 99%

Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)

Banys‐Paluchowski

Kühn²,

Masannat

et al. 2023

Cancers

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Background: Surgical excision of a non-palpable breast lesion requires a localization step. Among available techniques, wire-guided localization (WGL) is most commonly used. Other techniques (radioactive, magnetic, radar or radiofrequency-based, and intraoperative ultrasound) have been developed in the last two decades with the aim of improving outcomes and logistics. Methods: We performed a systematic review on localization techniques for non-palpable breast cancer. Results: For most techniques, oncological outcomes such as lesion identification and clear margin rate seem either comparable with or better than for WGL, but evidence is limited to small cohort studies for some of the devices. Intraoperative ultrasound is associated with significantly higher negative margin rates in meta-analyses of randomized clinical trials (RCTs). Radioactive techniques were studied in several RCTs and are non-inferior to WGL. Smaller studies show higher patient preference towards wire-free localization, but little is known about surgeons’ and radiologists’ attitudes towards these techniques. Conclusions: Large studies with an additional focus on patient, surgeon, and radiologist preference are necessary. This review aims to present the rationale for the MELODY (NCT05559411) study and to enable standardization of outcome measures for future studies.

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“…The experience in the UK [14] suggested that Magseed ® is a feasible method of breast localisation and may provide additional benefits over steel wire localisation for surgical scheduling and improved patient flow. In the study by Morgan et al [15], they listed difficult percutaneous localisation, interference with surgical instruments, and the need for probe recalibration as potential drawbacks of this technique. On the other hand, the learning curve was short for surgeons experienced in other localisation techniques.…”

Section: Magnetic Clipmentioning

confidence: 99%

The Magnetic Technique—A Novel and Promising Method to Improve Axillary Staging Localisation from a Swedish Perspective

Wärnberg,

Obondo,

Chin

2023

Medicina

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The magnetic technique using superparamagnetic nanoparticles of iron oxide has been well established for sentinel lymph node detection. Its main advantage is in the context of logistics, with the possibility to inject several weeks before surgery and the possibility to give access to sentinel lymph node biopsy for women worldwide in places without nuclear medicine facilities. We have not yet seen the full potential of this technique, and new implications have been developed for breast tumour localisation with paramagnetic clips and axillary staging after neoadjuvant chemotherapy using paramagnetic clips inserted in lymph node metastases before chemotherapy. In this report, we have presented our experience of the magnetic technique starting in 2014, and we have highlighted our current and future research directions.

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Results of shared learning of a new magnetic seed localisation device – A UK iBRA-NET breast cancer localisation study

Cited by 5 publications

References 27 publications

Clinical experience of the Magseed® magnetic marker to localize non-palpable breast lesions: a cohort study of 100 consecutive cases

Clinical experience of the Magseed® magnetic marker to localize non-palpable breast lesions: a cohort study of 100 consecutive cases

Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)

The Magnetic Technique—A Novel and Promising Method to Improve Axillary Staging Localisation from a Swedish Perspective

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