Results of Spirometry Among Individuals in a Silicosis Registry

Rosenman, Kenneth D.; Reilly, Mary Jo; Gardiner, Joseph C.

doi:10.1097/jom.0b013e3181fc5e50

Cited by 25 publications

(23 citation statements)

References 28 publications

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“…Similar patterns were also reported by Enfield et al []. This difference may be attributed to a mixed restrictive and obstructive pattern that is common in silicosis, particularly in the presence of progressive massive fibrosis [Rosenman et al, , Leung et al, ]. Other confounders that were not taken into account may also have disadvantaged survival among those with IPF relative to silicosis, masking worse outcomes for the latter (opposite to the pattern we observed), but these would have to be powerful unmeasured risks to be responsible for the observed protective effect of silicosis.…”

Section: Discussionsupporting

confidence: 86%

Survival following lung transplantation for artificial stone silicosis relative to idiopathic pulmonary fibrosis

Rosengarten

Fox

Fireman

et al. 2017

American J Industrial Med

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Section: Discussionsupporting

confidence: 86%

Survival following lung transplantation for artificial stone silicosis relative to idiopathic pulmonary fibrosis

Rosengarten

Fox

Fireman

et al. 2017

American J Industrial Med

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“…FVC and FEV 1 values trend down as the disease progresses, accompanied by increased radiologic findings . One study analyzed 526 spirometries of patients with various stages of silicosis and reported an obstructive pattern in 67.2% . On the other hand, another study analyzed patients with advanced silicosis who were on the waiting list for LTx, and found PFTs compatible with severe restrictive conditions.…”

Section: Discussionmentioning

confidence: 99%

“…As there are currently no criteria to classify end‐stage silicosis, which would call for LTx, we use the current International Society of Heart Lung Transplantation guidelines to define end‐stage disease . Patients who meet the above criteria are placed on the LTx wait list following a high‐resolution chest computed tomography (CT) scan . In this study, we included all patients on the wait list for LTx due to end‐stage silicosis at the ISCMPA between January 1, 1989, and July 31, 2015 (N = 26).…”

Section: Methodsmentioning

confidence: 99%

“…14,15 Patients who meet the above criteria are placed on the LTx wait list following a high-resolution chest computed tomography (CT) scan. [16][17][18] In this study, we included all patients on the wait list for LTx due to end-stage silicosis at the ISCMPA between January 1, 1989, and July 31, 2015 (N = 26). Sixteen of these patients received LTx (LTx group); 10 were eligible, but did not undergo LTx (non-LTx group) during the study period.…”

Section: Methodsmentioning

confidence: 99%

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What is expected in lung function after lung transplantation due to end‐stage pulmonary silicosis?

Sidney-Filho

Watte

Santos

et al. 2017

Clinical Transplantation

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In this study, we aimed to determine the impact of lung transplantation (LTx) on pulmonary function tests (PFTs) and survival among patients with end-stage silicosis. We included patients with end-stage silicosis on the wait list for LTx, between January 1989 and July 2015 (N = 26). Sixteen of these patients received LTx; 10 were eligible, but did not undergo LTx (non-LTx) during the study period. Retrospective information on PFTs (spirometry [volumes and flows], 6-minute walking test [6MWT], and DLCO) was retrieved from patients' medical charts, including baseline information for all patients and follow-up information for the LTx. At baseline, most patients presented with spirometric and 6MWT values that were suggestive of severe disease (FEV /FVC 76.5 ± 29.7; 6MWT 267.4 ± 104.5 m). Significant increases in these values were observed at follow-up in the LTx (P = .036 and .151, respectively). The overall median survival of patients in the LTx and non-LTx was 3.35 years (95% CI: 0.16-14.38) and 0.78 years (95% confidence interval [CI]: 0.12-3.65) (P = 0.002), respectively. For patients with end-stage silicosis, LTx offers significant benefits regarding pulmonary function and survival when compared to non-LTx, and is a reliable tool to help this critical population of patients, whose only treatment option is LTx.

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“…[6–8] Moreover, other pulmonary disorders including chronic obstructive pulmonary disease (COPD) [9,10] and lung cancer [11–13] are also associated with these occupational lung diseases. Both COPD and lung cancer manifest as irreversible disease courses and further result in poor prognoses among these patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic effect of tuberculosis on patients with occupational lung diseases

Hung

Su²,

Ou³

2016

Medicine

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Occupational lung diseases are well recognized risk factors for tuberculosis (TB). However, little research investigated the effect of TB on the clinical course and outcome of occupational lung diseases.We conducted a 13-year observational study of a nationwide cohort to evaluate the risk and prognosis of TB among patients with occupational lung diseases in Taiwan.By using the Taiwan National Health Insurance database, occupational lung diseases cohort was identified according to diagnosis codes from 1998 to 2008 and prospectively monitored until the end of 2010, loss to follow-up, or death. Newly diagnosed TB, comorbidities, and demographic characteristics were evaluated as prognostic variables in the survival analysis of patients with occupational lung diseases using Cox proportional hazard regression models.A total of 12,787 study participants were enrolled with an average of 9.69 years of follow-up. Among them, 586 (4.58%) had newly diagnosed TB and 3180 (24.87%) died during follow-up. The incidence of TB was 473 per 100,000 person-years, and the risk of TB infection significantly increased over time. The independent risk factors for mortality included male gender (hazard ratio [HR]: 2.23, 95% confidence interval [CI]: 1.91–2.60), age (HR: 1.05, 95% CI: 1.05–1.06), TB (HR: 1.17, 95% CI: 1.01–1.37), congestive heart failure (HR: 1.44, 95% CI: 1.17–1.79), cerebrovascular disease (HR: 1.34, 95% CI: 1.15–1.57), chronic obstructive pulmonary disease (HR: 1.44, 95% CI: 1.33–1.56), and asthma (HR: 1.27, 95% CI: 1.15–1.40). In addition, patients with TB infections had worse outcomes in the survival analysis than those without TB (log-rank test P = 0.02).Despite the low prevalence of occupational lung diseases in Taiwan, patients with those diseases had a higher TB incidence than the general population did (473 vs 55 per 100,000 person-years). Furthermore, even with effective antimicrobial chemotherapy, TB infection was a prognostic factor leading to poor outcomes in the patients with occupational lung diseases. We recommend intensive medical surveillance of TB in these high-risk patients for better control of TB and improvement of occupational health in Taiwan.

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Results of Spirometry Among Individuals in a Silicosis Registry

Cited by 25 publications

References 28 publications

Survival following lung transplantation for artificial stone silicosis relative to idiopathic pulmonary fibrosis

Survival following lung transplantation for artificial stone silicosis relative to idiopathic pulmonary fibrosis

What is expected in lung function after lung transplantation due to end‐stage pulmonary silicosis?

Prognostic effect of tuberculosis on patients with occupational lung diseases

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