Results of surgery in small cell carcinoma of the lung

Antonio, David Gómez de; Alfageme, Fernando; Gámez, Pablo; Córdoba, María Alejandra; Varela, A.

doi:10.1016/j.lungcan.2006.01.012

Cited by 24 publications

(11 citation statements)

References 24 publications

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“…They therefore recommended surgery in the treatment of localized SCLC. The Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S) presented results from a multicenter study with a 5-year survival rate of 36 % for p-stage I [26]. JCOG 9101 reported 3-year survival rates of 68, 56, and 13 % in patients with c-stage I, II, and IIIA, respectively [14].…”

Section: Surgical Interventionmentioning

confidence: 99%

Surgical intervention for small-cell lung cancer: what is the surgical role?

Inoue

Sawabata

Okumura

2012

Gen Thorac Cardiovasc Surg

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Small-cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma that accounts for approximately 10–15 % of all lung cancer cases. This histological subtype is a distinct entity with biological and oncological features differing from non-small cell lung cancer (NSCLC). Treatment is mainly performed using systemic chemotherapy, although surgery in association with chemotherapy may be indicated for a minor proportion of limited-disease cases. Since the outcomes after surgical intervention in patients with very early disease are comparable to those for NSCLC, accurate clinical staging is required, particularly in terms of nodal involvement. In addition to conventional mediastinoscopy, positron emission tomography-computed tomography and endobronchial ultrasonography guided transbronchial needle aspiration have recently become available for node diagnosis. The significance of surgery for SCLC includes local disease control and treatment for cases showing mixed histology. However, only two randomized control studies have examined the efficacy of surgery in SCLC, and both yielded negative results and are out of date. We review herein several studies concerning surgery for SCLC and discuss the results from a practical standpoint. A prospective trial performed in collaboration with pulmonologists is required to address the significance of surgery, which is a limited option in the treatment of SCLC.

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Section: Surgical Interventionmentioning

confidence: 99%

Surgical intervention for small-cell lung cancer: what is the surgical role?

Inoue

Sawabata

Okumura

2012

Gen Thorac Cardiovasc Surg

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“…However, recent studies have shown a reasonable survival rate in patients who underwent surgery plus CHT as curative-intent therapy for VLD-stage SCLC. [89] Most recently, Yu et al . analyzed 247 patients who underwent surgical lobectomy with or without thoracic RT (TRT) for stage I SCLC.…”

Section: Discussionmentioning

confidence: 99%

Relevance of an incidental chest finding

Cortés-Télles¹,

Mendoza²

2012

Lung India

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Solitary pulmonary nodule represents 0.2% of incidental findings in routine chest X-ray images. One of the main diagnoses includes lung cancer in which small-cell subtype has a poor survival rate. Recently, a new classification has been proposed including the very limited disease stage (VLD stage) or T1-T2N0M0 with better survival rate, specifically in those patients who are treated with surgery. However, current recommendations postulate that surgery remains controversial as a first-line treatment in this stage. We present the case of a 46-year-old female referred to our hospital with a preoperative diagnosis of a solitary pulmonary nodule. On initial approach, a biopsy revealed a small cell lung cancer. She received multimodal therapy with surgery, chemotherapy, and prophylactic cranial irradiation and is currently alive without recurrence on a 2-year follow-up.

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“…The control group of patients treated with chemoradiotherapy was built using pair-matched case-control according to main prognostic factors, stage and resectability; moreover diagnosis of surgical treated patients was established only postoperatively, thus minimizing some bias related to selection of patients. In 2006 the Bronchogenic Carcinoma Cooperative Group of the Spanish Society of Pneumology and Thoracic Surgery (GCCB-S) presented a multicenter study on 47 patients with SCLC out a total of 2994 lung cancers resected [Gomez de Antonio, 2006]. Thirty-three % of patients had incomplete resection suggesting that the criteria for surgery were not predictable enough for resectability.…”

Section: Studies Regarding Surgery In Sclcmentioning

confidence: 99%