Results of the 2006 Innsbruck International Consensus Conference on intraperitoneal chemotherapy in patients with ovarian cancer

Abstract

During the formation of organic–inorganic hybrid materials by the sol–gel process, the observation of multiphase systems at different stages of the reaction is not uncommon. An assessment of the chemical species formed before and after gelation is not an easy task because complex mixtures are generally found in these systems. In this study, the identification of intermediates developed during the formation of a hybrid obtained from tetraethoxysilane (TEOS) and 4‐[(5‐dichloromethylsilyl)pentyloxy]cyanobenzene monomer has been undertaken. Solution and solid‐state 29Si‐ and 13C‐NMR spectra, recorded at different degrees of conversion, allow the elucidation of the mechanism of hybrid formation. 4‐[(5‐dichloromethylsilyl)pentyloxy]cyanobenzene, (DCN), DCN–TEOS cyclosiloxanes and low‐molecular‐weight linear copolysiloxanes are formed in the early stages of the process and before gelation occur. Before the gel is formed, cyclic species undergo an acid‐catalyzed ring‐opening copolymerization with silica to produce a random copolymer. Other intermediates of the Qij type (where Q indicates a four‐functional silicon, the first subscript indicates the number of siloxane bridges connected to the silicon site, and the second subscript indicates the number of silanol groups) that develop before the gel is formed have also been identified. Spectral peak patterns of the final hybrid, observed in solid‐state 29Si and 13C‐NMR spectra, are also discussed. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 520–531, 2006

Ovarian Cancer, Version 2.2013

“…Robert H. Lurie Comprehensive Cancer Center of Northwestern University; 21 Stanford Cancer Institute; 22 Huntsman Cancer Institute at the University of Utah; and 23 National Comprehensive Cancer Network.…”

Cytoreductive surgery (SRC) for treatment of peritoneal carcinomatosis and hyperthermic ıntraperitoneal chemotherapy (HIPEC): Our initial experience and technical details

“…Certain measures should be taken against these side effects before and during application of HIPEC (70). Paclitaxel related myelosuppression and neurotoxicity, oxaliplatin-induced neurotoxicity, and increase in the risk of infection secondary to any drug are important (71). In our study, there were no toxic side effects other than minimal bone marrow depression in one patient.…”

Intraperitoneal Chemotherapy in Ovarian Cancer

“…However, in cases where it is performed earlier, the renal toxicity should be considered. Some physicians wait as long as the patient returns to the normal bowel movement and the ileus is resolved after the surgery to ensure that there are no preoperative complications (18).…”