Results of the BfR MEAL Study: In Germany, mercury is mostly contained in fish and seafood while cadmium, lead, and nickel are present in a broad spectrum of foods

Fechner, Carolin; Hackethal, Christin; Höpfner, Tobias; Dietrich, Jessica; Bloch, Denise; Lindtner, Oliver; Sarvan, Irmela

doi:10.1016/j.fochx.2022.100326

Cited by 16 publications

(10 citation statements)

References 23 publications

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“…Environmental exposure to cadmium (Cd) is inevitable for most people because the metal is present in almost all food types [ 1 , 2 , 3 ]. The realization in the 1940s that the condition referred to as “itai-itai” disease was due to the consumption of rice heavily contaminated with Cd brought into focus the real threat to health posed by this metal [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

The NOAEL Equivalent of Environmental Cadmium Exposure Associated with GFR Reduction and Chronic Kidney Disease

Satarug

Djordjevic

Yimthiang

et al. 2022

Toxics

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Cadmium (Cd) is a highly toxic metal pollutant present in virtually all food types. Health guidance values were established to safeguard against excessive dietary Cd exposure. The derivation of such health guidance figures has been shifted from the no-observed-adverse-effect level (NOAEL) to the lower 95% confidence bound of the benchmark dose (BMD), termed BMDL. Here, we used the PROAST software to calculate the BMDL figures for Cd excretion (ECd) associated with a reduction in the estimated glomerular filtration rate (eGFR), and an increased prevalence of chronic kidney disease (CKD), defined as eGFR ≤ 60 mL/min/1.73m2. Data were from 1189 Thai subjects (493 males and 696 females) mean age of 43.2 years. The overall percentages of smokers, hypertension and CKD were 33.6%, 29.4% and 6.2%, respectively. The overall mean ECd normalized to the excretion of creatinine (Ecr) as ECd/Ecr was 0.64 µg/g creatinine. ECd/Ecr, age and body mass index (BMI) were independently associated with increased prevalence odds ratios (POR) for CKD. BMI figures ≥ 24 kg/m2 were associated with an increase in POR for CKD by 2.81-fold (p = 0.028). ECd/Ecr values of 0.38−2.49 µg/g creatinine were associated with an increase in POR for CKD risk by 6.2-fold (p = 0.001). The NOAEL equivalent figures of ECd/Ecr based on eGFR reduction in males, females and all subjects were 0.839, 0.849 and 0.828 µg/g creatinine, respectively. The BMDL/BMDU values of ECd/Ecr associated with a 10% increase in CKD prevalence were 2.77/5.06 µg/g creatinine. These data indicate that Cd-induced eGFR reduction occurs at relatively low body burdens and that the population health risk associated with ECd/Ecr of 2.77−5.06 µg/g creatinine was not negligible.

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Section: Introductionmentioning

confidence: 99%

The NOAEL Equivalent of Environmental Cadmium Exposure Associated with GFR Reduction and Chronic Kidney Disease

Satarug

Djordjevic

Yimthiang

et al. 2022

Toxics

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“…The mean Ni concentrations in the current study were higher than those in a Chinese market-basket study for aquatic and cereal products, but not for beans and vegetables, with cereals, beans, vegetables, and fish having mean Ni concentrations of 0.56 mg/kg, 5.11 mg/kg, 0.09 mg/kg, and 0.02 mg/kg, respectively [ 17 ]. A study from Germany collectively analyzed legumes, nuts, oilseeds, and spices and found a mean Ni level of 1.562 mg/kg (range: 0.064 to 5.35 mg/kg) [ 27 ]. Consistent results were found in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Severe global initiatives have been undertaken to control Ni levels in food products, but distinct results have been found between different regions. In the European market, chocolate has a relatively high Ni content, and its levels are generally comparable [ 27 , 28 , 29 ]. In the Canadian region, despite having substantial Ni reserves and economic development, no study has identified Ni pollution [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Exposure Assessment of Nickel in Zhejiang Province, China

Han,

Zhang,

Tang

et al. 2024

Toxics

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Nickel (Ni) is a silver-white metal with high antioxidative properties, often existing in a bivalent form in the environment. Despite being the fifth most abundant metal on Earth, anthropogenic activities, including industrial processes, have elevated Ni levels in environmental media. This study investigated Ni contamination in various food groups in Zhejiang Province, China, mainly focusing on Ni levels in beans, vegetables, aquatic foods, meat products, cereal products, and fruits. A total of 2628 samples were collected and analyzed. Beans exhibited the highest Ni content in all samples. The overall detection rate of Ni was 86.5%, with variation among food categories. For plant-origin foods, legumes had the highest Ni concentration while for animal-origin foods, shellfish showed the highest median Ni concentration. The results indicate generally acceptable Ni exposure levels among Zhejiang residents, except for children aged 0–6. Beans were identified as the primary contributor to high Ni exposure risk. The paper suggests monitoring Ni contamination in food, especially for vulnerable populations, and provides insights into exposure risks in different age groups.

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“…und tierischen Ursprungs (Fische, Krustentiere, Weichtiere, Fleisch und Innereien; [ 8 – 12 ]). Neuere Untersuchungen zum Vorkommen von (Halb‑)Metallen in Lebensmitteln im Rahmen der amtlichen Überwachung oder der BfR-MEAL-Studie des Bundesinstituts für Risikobewertung (MEAL: Mahlzeiten für die Expositionsschätzung und Analytik von Lebensmitteln) zeigen, dass in bestimmten Lebensmitteln höhere Konzentrationen zu erwarten sind [ 13 – 15 ].…”

Section: Kontaminanten In Der Nahrungskette Im Sinne Des One-health-k...unclassified

Das One-Health-Konzept im Kontext globaler Warenketten, Krisen und der Sicherheit von Lebens- und Futtermitteln

Mader,

Riede,

Pabel

et al. 2023

Bundesgesundheitsbl

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ZusammenfassungDie ganzheitliche Betrachtung der Lebens- und Futtermittelsicherheit unter Einbeziehung der Tiergesundheit und der Umweltbedingungen ist eine wichtige Säule des One-Health-Ansatzes. Die Begrifflichkeit geht damit deutlich über die häufig darunter verstandene Vermeidung der Verbreitung von übertragbaren mikrobiologischen Krankheiten hinaus und verdeutlicht, dass Mensch, Tiere und Umwelt sowie ihre Interaktionen in einem transdisziplinären Kontext betrachtet werden sollten.In dem vorliegenden Diskussionsbeitrag zum One-Health-Ansatz liegt der Fokus weniger auf mikrobiologischen Risiken, sondern es wird insbesondere der Zusammenhang zu chemischen Risiken in der Nahrungskette hergestellt. Dieser wird an konkreten Beispielen chemischer Kontaminanten (Metalle, persistente organische Kontaminanten und natürliche Toxine) verdeutlicht und die Mechanismen von Eintrag und Weitergabe entlang der Nahrungsketten werden vorgestellt.Die Minimierung des Vorkommens chemischer Kontaminanten und somit der Exposition erfordert internationale und interdisziplinäre Zusammenarbeit. Klimawandel, Pandemien, Rohstoffknappheit, Energiemangel, politische Krisen und Umweltkatastrophen können die gesamte Kette der Primärproduktion pflanzlicher und tierischer Lebensmittel sowie die Weiterverarbeitung und Bereitstellung der Produkte für Verbraucherinnen und Verbraucher beeinträchtigen. Neben der sich verändernden Verfügbarkeit kann dies auch einen Einfluss auf die Zusammensetzung, Qualität und Sicherheit der Lebens- und Futtermittel haben. Anhand der Effekte auf globalen Warenketten werden vulnerable und resiliente Bereiche sichtbar. Im Sinne des One-Health-Ansatzes gilt es, die Sicherheit und Resilienz entlang der Nahrungskette zu erhöhen und deren Vulnerabilität zu minimieren.

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Results of the BfR MEAL Study: In Germany, mercury is mostly contained in fish and seafood while cadmium, lead, and nickel are present in a broad spectrum of foods

Cited by 16 publications

References 23 publications

The NOAEL Equivalent of Environmental Cadmium Exposure Associated with GFR Reduction and Chronic Kidney Disease

The NOAEL Equivalent of Environmental Cadmium Exposure Associated with GFR Reduction and Chronic Kidney Disease

Occurrence and Exposure Assessment of Nickel in Zhejiang Province, China

Das One-Health-Konzept im Kontext globaler Warenketten, Krisen und der Sicherheit von Lebens- und Futtermitteln

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