Results of the Fructose Breath Test in Healthy Controls Using Different Doses of Fructose: Which Dose Is Best?

Doma, Siva; Gaddipati, Kishore; Fernandez, Angel; Friedenberg, Frank K.; Bromer, Matthew Q.; Parkman, Henry P.

doi:10.1111/j.1572-0241.2003.08537.x

Cited by 6 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As testing in healthy adults has shown, a person who tests positive for malabsorption at 50 g of fructose may fully absorb the sugar and test negative when given 25 g of fructose. 39,41,42,44 Sugar dose, therefore, has a strong influence on the fructose BHT result, and a high proportion of healthy children may test positive with the high doses of fructose commonly used in published studies. 4 Given the varying doses of sugar used in different studies and testing clinics, it would seem more informative to express fructose malabsorption test results as a function of the dose given.…”

Section: Resultsmentioning

confidence: 99%

“…However, this may be less appropriate in the scenario of fructose malabsorption, due to the variable absorption capacity of individuals. As testing in healthy adults has shown, a person who tests positive for malabsorption at 50 g of fructose may fully absorb the sugar and test negative when given 25 g of fructose . Sugar dose, therefore, has a strong influence on the fructose BHT result, and a high proportion of healthy children may test positive with the high doses of fructose commonly used in published studies .…”

Section: Resultsmentioning

confidence: 99%

“…Using a fixed dose, the proportion of those tested who showed incomplete fructose absorption on a BHT was strongly dependent on the size of the fructose dose given. 29 Absorption capacity in healthy individuals has been more extensively studied in adults, with 58-87% of subjects testing positive with a 50 g dose of fructose, 39-43 10-53% testing positive with 25 g, 39,41,42,44 and 0-10% testing positive with 15 g. 41,44 An increasing proportion of positivity with increasing dose was also found in a study of children with persistent, unexplained abdominal pain when consuming 1 g (0 of 9 positive), 15 g (3 of 10 positive), and 45 g (8 of 13 positive). 22 This indicates that, similar to adults, a positive BHT result for fructose malabsorption in children may be dependent on the size of the dose given.…”

Section: Fructose Dosementioning

confidence: 99%

See 2 more Smart Citations

Developmental changes and fructose absorption in children: effect on malabsorption testing and dietary management

et al. 2013

View full text Add to dashboard Cite

Fructose malabsorption came to prominence in the pediatric arena as so-called "apple juice diarrhea," with excess consumption of fructose being linked to gastrointestinal symptoms such as diarrhea and abdominal pain. Over the past two decades the amount of fructose in children's diets has been increasing in the United States. A test for fructose malabsorption has yet to be fully validated, due mainly to the lack of an established etiology. In animal models, however, the fructose transporter GLUT5 is developmentally regulated, and this could be consistent with the greater susceptibility of children, especially toddlers, to fructose malabsorption. Additionally, the available evidence indicates the fructose breath hydrogen test has no apparent diagnostic utility in infants younger than 1 year; it may, therefore, be advisable to test for malabsorption by dietary exclusion in these patients. The present review aims to expound on the biological basis for fructose malabsorption in children and evaluate the current evidence for diagnostic procedures in order to identify clinical testing strategies that can be recommended and areas where further investigation is required.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Fructose Dosementioning

confidence: 99%

See 1 more Smart Citation

Developmental changes and fructose absorption in children: effect on malabsorption testing and dietary management

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The proportion of malabsorption on the fructose BHT is also dependent on the dose of fructose given (9). This effect has been more extensively studied in adults than children; in healthy adults, 58% to 87% tested positive by BHT when given a 50-g dose of fructose (20)(21)(22)(23), 10% to 53% tested positive with a 25-g dose (20,(22)(23)(24), and 0% to 10% with a 15-g dose (22,24). Variation in the proportion of individuals testing positive may also reflect variance in factors such as the subject populations, the volume of water used to dilute the sugar, or differing diagnostic cutoffs (25) (cutoffs of 10 ppm (11,13) and 20 ppm (9,10,12) are used in children).…”

Section: Discussionmentioning

confidence: 99%

Effect of Age on Fructose Malabsorption in Children Presenting With Gastrointestinal Symptoms

Jones

Burt²,

Dowling

et al. 2011

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

The majority of infants with gastrointestinal symptoms exhibited fructose malabsorption, but the capacity to absorb fructose increased with patient age up to 10 years old. The low threshold for fructose absorption in younger children has significant implications for the performance and interpretation of the fructose BHT and for the dietary consumption of fructose in infants with gastrointestinal symptoms.

show abstract

“…Fructose hydrogen breath testing (BHT) is employed in clinical settings to diagnose malabsorption. However, a comprehensive validation of this test with established testing conditions and diagnostic thresholds is still lacking [50][51][52].…”

Section: Fructose Intolerance and Ibdmentioning

confidence: 99%

Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives

Capobianco,

Di Vincenzo,

Puca

et al. 2024

Nutrients

View full text Add to dashboard Cite

Limited knowledge is available about the relationship between food allergies or intolerances and inflammatory bowel disease (IBD). Clinicians frequently encounter patients who report food allergies or intolerances, and gastroenterologists struggle distinguishing between patients with organic disorders and those with functional disorders, which the patients themselves may associate with specific dietary components. This task becomes even more arduous when managing patients with significant underlying organic conditions, like IBD. The aim of this review is to summarize and emphasize any actual associations between food allergies and intolerances and inflammatory diseases, such as ulcerative colitis and Crohn’s disease. Through a narrative disceptation of the current literature, we highlight the increased prevalence of various food intolerances, including lactose, fructose, histamine, nickel, and non-celiac gluten sensitivity, in individuals with IBD. Additionally, we explore the association between increased epithelial barrier permeability in IBD and the development of food sensitization. By doing so, we aim to enhance clinicians’ awareness of the nutritional management of patients with IBD when facing complaints or evidence of food allergies or intolerances.

show abstract

Results of the Fructose Breath Test in Healthy Controls Using Different Doses of Fructose: Which Dose Is Best?

Cited by 6 publications

References 0 publications

Developmental changes and fructose absorption in children: effect on malabsorption testing and dietary management

Developmental changes and fructose absorption in children: effect on malabsorption testing and dietary management

Effect of Age on Fructose Malabsorption in Children Presenting With Gastrointestinal Symptoms

Adverse Food Reactions in Inflammatory Bowel Disease: State of the Art and Future Perspectives

Contact Info

Product

Resources

About