Results of the Gore Bio-A fistula plug implantation in the treatment of anal fistula: a multicentre study

Herold, Alexander; Ommer, A.; Fürst, Alois; Pakravan, F.; Hahnloser, Dieter; Strittmatter, Beate; Schiedeck, Thomas; Hetzer, Franc; Aigner, Felix; Berg, E.; Roblick, Michael; Bussen, D.; Joós, A; Vershenya, S.

doi:10.1007/s10151-016-1505-8

Cited by 21 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One is the LIFT technique (ligation of intersphincteric fistula tract), which has success rates ranging from 39.8% [12] to about 82% [13], with vast differences in results of the LIFT technique reported by different authors [14]. Other techniques, such as fistula plugs, have been verified by several studies and proved to not be as efficient as was initially estimated [15]. …”

Section: Discussionmentioning

confidence: 99%

Video-Assisted Anal Fistula Treatment: Pros and Cons of This Minimally Invasive Method for Treatment of Perianal Fistulas

Romaniszyn

Wałęga

2017

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Purpose The purpose of this paper is to present results of a single-center, nonrandomized, prospective study of the video-assisted anal fistula treatment (VAAFT). Methods 68 consecutive patients with perianal fistulas were operated on using the VAAFT technique. 30 of the patients had simple fistulas, and 38 had complex fistulas. The mean follow-up time was 31 months. Results The overall healing rate was 54.41% (37 of the 68 patients healed with no recurrence during the follow-up period). The results varied depending on the type of fistula. The success rate for the group with simple fistulas was 73.3%, whereas it was only 39.47% for the group with complex fistulas. Female patients achieved higher healing rates for both simple (81.82% versus 68.42%) and complex fistulas (77.78% versus 27.59%). There were no major complications. Conclusions The results of VAAFT vary greatly depending on the type of fistula. The procedure has some drawbacks due to the rigid construction of the fistuloscope and the diameter of the shaft. The electrocautery of the fistula tract from the inside can be insufficient to close wide tracts. However, low risk of complications permits repetition of the treatment until success is achieved. Careful selection of patients is advised.

show abstract

Section: Discussionmentioning

confidence: 99%

Video-Assisted Anal Fistula Treatment: Pros and Cons of This Minimally Invasive Method for Treatment of Perianal Fistulas

Romaniszyn

Wałęga

2017

Gastroenterology Research and Practice

View full text Add to dashboard Cite

show abstract

“…These are suitable for mammoplasty, inguinal hernia and intestinal fistula surgical treatments. 14,15 The Phasix TM ST Mesh (CR Bard, Inc.) is composed of poly-4hydroxybutyrate, it is resorbed in 52 weeks, and its clinical usage is still limited. 16 The study was preceded by empirical selection among experimental mesh samples, which differed by the material (polydioxanone [PDO], PGA, polylactide and poly(lactide-coglycolide)), filament thickness and knitting mode.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of resorbable polydioxanone and polyglycolic acid meshes in a rat model of ventral hernia repair

et al. 2018

View full text Add to dashboard Cite

The objective of this study was to evaluate physical, mechanical, and biological properties of the polydioxanone (PDO) monofilament meshes and polyglycolide (PGA) polyfilament meshes in comparison with Permacol implants. In rat experimental model, a 1.5 × 2.0 cm defect in abdominal wall was reconstructed by using the Permacol surgical implant or knitted meshes produced from either PDO monofilament, or PGA multifilament. The implant sites were assessed for the tensile strength and the extents of material resorption, host inflammatory response and host tissue replacement on days 3, 10, 30, or 60 after the surgery. The PDO and PGA meshes were rapidly pervaded by the host connective tissue with elements of skeletal muscle histogenesis. The degree of adhesions was significantly higher in the Permacol group. All of the prostheses underwent resorption, which correlated with gradual decreases in the overall tensile strength of the site and the Col1a1 gene expression level. Elevated expression of Fgf2 gene maintained longer in the PDO group, and the Mmp9 gene expression level in this group was higher than in the other groups. Gene expression levels of inflammatory cytokines were higher in the Permacol group. The foreign body giant cell numbers were lower in the PDO and Permacol groups than in the PGA group. Minimal macrophage infiltration with predominance of M2 cells was observed in the PDO group. Overall, the PDO prosthesis turned out to be significantly better than the PGA or Permacol prostheses by a number of indicators of biocompatibility and efficacy. © 2018 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 00B: 000-000, 2018.

show abstract

“…The results are illustrated in Tables and . A total of 39 AFP‐related studies and 43 RAF‐related studies were involved in this analysis. Subsequently, we mapped the healing rate and median follow‐up time of each study into a scatter plot.…”

Section: Resultsmentioning

confidence: 99%

Anal fistula plug vs rectal advancement flap for the treatment of complex cryptoglandular anal fistulas: a systematic review and meta‐analysis of studies with long‐term follow‐up

et al. 2018

View full text Add to dashboard Cite

AimThe aim was to compare the effectiveness of the anal fistula plug (AFP) with the rectal advancement flap (RAF) for complex cryptoglandular anal fistulas. MethodsWe conducted a literature search to identify relevant available articles published without language restriction from Embase and PubMed databases and the Cochrane Library. Studies comparing outcomes with the AFP vs RAF for complex cryptoglandular anal fistulas were eligible for inclusion.Results A total of 11 articles with 810 patients were included in this meta-analysis. Four RCTs and one observational clinical study provided long-term followup. The pooled analysis of all 11 studies indicated that there was no significant difference between the AFP and RAF in terms of healing rate, recurrence rate and incidence of fistula complications. However, the pooled results of studies with long-term follow-up revealed that the RAF group had a significantly higher healing rate (OR 0.32, 95% CI 0.13, 0.78, P = 0.01) and lower recurrence rate (OR 4.45, 95% CI 1.45, 13.65, P = 0.009) than the AFP group.Conclusions For the treatment of complex cryptoglandular anal fistulas, the RAF was superior to the AFP in terms of healing and recurrence rate after pooling of randomized controlled trials with long-term follow-up, even though a comparison based on the pooling of all studies showed no significant difference.

show abstract

Results of the Gore Bio-A fistula plug implantation in the treatment of anal fistula: a multicentre study

Abstract: Synthetic plugs may be an alternative to bioprosthetic fistula plugs in the treatment of transsphincteric anal fistulas. This method might have better success rates than treatment with bioprosthetic fistula plugs.

Cited by 21 publications

References 22 publications

Video-Assisted Anal Fistula Treatment: Pros and Cons of This Minimally Invasive Method for Treatment of Perianal Fistulas

Video-Assisted Anal Fistula Treatment: Pros and Cons of This Minimally Invasive Method for Treatment of Perianal Fistulas

Evaluation of resorbable polydioxanone and polyglycolic acid meshes in a rat model of ventral hernia repair

Anal fistula plug vs rectal advancement flap for the treatment of complex cryptoglandular anal fistulas: a systematic review and meta‐analysis of studies with long‐term follow‐up

Contact Info

Product

Resources

About