Results of the Impact of Antiproteinase Hemosorbent on the Dynamics of the Main Markers of Inflammation in Children With Severe Forms of Peritonitis

Abstract

Aim: To study the effect of the antiproteinasehemosorbent “Hemo-proteasesorb” on the dynamics of the main markers of inflammation in the complex intensive care of children with generalized peritonitis. Material and methods: A prospective randomized study of 60 children with generalizedperitonitis was conducted. Group I included 30 patients who underwent hemoperfusion through the sorbent “Hemo-proteazsorb”. Group II included 30 patients who underwent traditional treatment. The examined groups were comparable in the nature of pathology and severity of the condition. Results: After hemoperfusion, a significant decrease in the main markers of inflammation was found: C-reactive protein decreased from 83.7 (72.2; 131.3) to 12.9 (10.0;22.0) (p=0,0003) mg/l, procalcitonin level normalized from 4.65 (2.1;7.4) to 0.21 (0.07;0.4) (p=0,00002) ng/ml, presepsin level decreased from 5.7 (2.5; 8.8) to 0.4 (0.3; 0.8) (p=0,25) ng/ml, the level of IL-6 decreased from 25.3 (6.0; 68.8) to 4.6 (0.9; 8.3) (p=0.000001) pg/ml. When compared in the second group, the studied indicators changed much more slowly. Conclusions: The data obtained as a result of the study indicate a decrease in the severity of the inflammatory process, a decrease in the risk of sepsis in the group of patients who underwent hemoperfusion, and thereby prove the effectiveness of this method.