This paper describes the effects of particle sphericity, interfacial thermal resistance, stereography, and heat generation on the thermal conductivity of U-Mo/Al dispersion fuel. The ABAQUS finite element method (FEM) tool was used to calculate the effective thermal conductivity of U-Mo/Al dispersion fuel by implementing fuel particles. For U-Mo/Al, the particle sphericity effect was insignificant. However, if the effect of the interfacial thermal resistance between the fuel particles and Al matrix was considered, the thermal conductivity of U-Mo/Al was increased as the particle size increases. To examine the effect of stereography, we compared the two-dimensional modeling and three-dimensional modeling. The results showed that the two-dimensional modeling predicted lower than the three-dimensional modeling. We also examined the effect of the presence of heat sources in the fuel particles and found a decrease in thermal conductivity of U-Mo/Al from that of the typical homogeneous heat generation modeling.