Results of Three-Dimensional Conformal Radiation Therapy for the Treatment of a Solitary Sternal Relapse of Breast Cancer

Kim, Haeyoung; Huh, Seung Jae; Park, Won; Choi, Do Ho; Kang, Min Kyu; Yang, Jung‐Hyun; Nam, Seok‐Jin; Im, Young‐Hyuck

doi:10.3857/jkstro.2008.26.2.91

Cited by 2 publications

(1 citation statement)

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“…Several studies showed that patients with disease-free interval at least two years had better DFS as well as OS compared with the patients with shorter disease-free interval [5,7,9,12,15,17-19]. In the study of Schmoor et al [15], they defined different time-dependent covariates for the disease-free interval (≤1, 1-2, 2-5, or >5 years) and showed that the patients with the short disease-free interval had poor prognosis for DFS and OS than the patients with the long disease-free interval.…”

Section: Discussionmentioning

confidence: 99%

Treatment results of breast cancer patients with locoregional recurrence after mastectomy

et al. 2013

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PurposeTo analyze the results of locoregional and systemic therapy in the breast cancer patients with locoregional recurrence (LRR) after mastectomy.Materials and MethodsSeventy-one patients who received radiotherapy for isolated LRR after mastectomy between January 1999 and December 2009 were retrospectively reviewed. Among the 71 patients, 59 (83.1%) underwent wide excision and radiotherapy and 12 (16.9%) received radiotherapy alone. Adjuvant hormonal therapy was given to 45 patients (63.4%). Oncologic outcomes including locoregional recurrence-free survival, disease-free survival (DFS), and overall survival (OS) and prognostic factors were analyzed.ResultsMedian follow-up time was 49.2 months. Of the 71 patients, 5 (7%) experienced second isolated LRR, and 40 (56%) underwent distant metastasis (DM). The median DFS was 35.6 months, and the 3- and 5-year DFS were 49.1% and 28.6%, respectively. The median OS was 86.7 months, and the 5-year OS was 62.3%. Patients who received hormone therapy together showed better 5-year DFS and OS than the patients treated with locoregional therapy only (31.6% vs. 22.1%, p = 0.036; 66.5% vs. 55.2%, p = 0.022). In multivariate analysis, higher N stage at recurrence was a significant prognostic factor for DFS and OS. Disease free interval (≤30 months vs. >30 months) from mastectomy to LRR was also significant for OS. The patients who received hormone therapy showed superior DFS and showed trend to better OS.ConclusionDM was a major pattern of failure after the treatment of LRR after mastectomy. The role of systemic treatment for LRR after mastectomy should be investigated at prospective trials.

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Section: Discussionmentioning

confidence: 99%

Treatment results of breast cancer patients with locoregional recurrence after mastectomy

et al. 2013

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Case Report: A Rare Case of Sternal Erosion Due to Bronchogenic Carcinoma

Pandit¹,

Das²,

Das³

et al. 2014

Ethiop J Health Sci

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BackgroundPrimary sternal malignancy is very uncommon. Secondary sternal malignancy is usually caused by either hematological dissemination or by direct extension due to parasternal lymph node involvement from breast or lung carcinoma.Case DetailsA 72 years old smoker presented with a dull aching pain over the sternum. Computed tomography (CT) of the thorax revealed osteolytic erosion of manubrium sterni, along with a mass of lesion in the upper lobe of left lung and left sided mediastinal lymphadenopathy. CT guided fine needle aspiration cytology (FNAC) of the left lung mass showed squamous cell carcinoma and FNAC of the sternal lesion revealed metastatic squamous cell carcinoma.ConclusionDirect erosion of sternum in case of squamous cell carcinoma of lung is a rarity. We have reported this case to increase the awareness of clinicians regarding the possibility of direct sternal involvement from lung cancer. Moreover, local removal can improve the prognosis.

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Results of Three-Dimensional Conformal Radiation Therapy for the Treatment of a Solitary Sternal Relapse of Breast Cancer

Cited by 2 publications

References 13 publications

Treatment results of breast cancer patients with locoregional recurrence after mastectomy

Treatment results of breast cancer patients with locoregional recurrence after mastectomy

Case Report: A Rare Case of Sternal Erosion Due to Bronchogenic Carcinoma

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