The purpose of our study was to evaluate the feasibility of salvage surgery for patients with persistent or recurrent maxillary sinus cancer after superselective intra-arterial cisplatin infusion with concomitant radiotherapy (RADPLAT). We retrospectively analyzed 61 patients with maxillary sinus cancer who underwent RADPLAT.Chemotherapy comprised 100-120 mg/m 2 superselective intra-arterial cisplatin administered at a median rate of four times weekly. Concurrent radiation therapy was administered at a median dose of 65Gy. Persistent/recurrent maxillary sinus cancer was observed in 17 patients. Salvage surgery was performed in 11 patients.Persistent/recurrent primary disease was controlled in 8 of 11 patients undergoing salvage surgery (72.7%). Seven of 11 patients undergoing salvage surgery (63.6%) have survived without any evidence of disease. The 5-year overall survival rate of patients undergoing salvage surgery was calculated to be 60.6%. The incidence rate of significant perioperative complications was 18.2% (2/11). Salvage surgery for patients with persistent/recurrent maxillary sinus cancer after RADPLAT is considered to be both safe and successful. We also consider that salvage surgery is good option when persistent/recurrent maxillary sinus cancer is observed after RADPLAT.