Resurgent neuropathic discharge: an obstacle to the therapeutic use of neuroma resection?

Abstract

Resecting a previously injured nerve in rats did not trigger resurgent ectopic neuropathic discharge or resurgent pain behavior, perhaps mitigating this concern in patients with pain.

Pain in Osteoarthritis: Driven by Intrinsic Rather Than Extrinsic Joint Afferents and Why This Should Impact Treatment

“…In dental root-canal treatment as well, painful neuromas are a very rare complication. The reasons for this are uncertain [2,16]. For OA of the hip treating the femoral epiphysis might be sufficient, but for OA of the knee or digits both apposed bone ends would presumably need to be treated.…”

Strategies for Treating Traumatic Neuromas with Tissue-Engineered Materials

“…When a peripheral nerve is damaged, if the severed nerve ends are too far apart or there is a scar or other tissue barrier between them, or if the distal end is lost due to amputation, the regenerated axons fail to reach the distal end and intertwine with the proliferation of connective tissue, forming a coiled mass known as traumatic neuroma [2]. The prominent symptom is the existence of typical percussion pain and tenderness in the region of pain hypersensitivity (dysesthesia) or neuroma, which can impact the patient's work and daily life, causing significant distress to the patient [3].…”

“…This can help manage pain and inflammation, crucial aspects in the treatment of traumatic neuromas [13]. (3) Structural support and guidance: Tissue-engineered nerve repair materials can provide structural support and protection for the injured stump [14]. This is particularly important in preventing the formation of disorganized and painful neuromas.…”