2018
DOI: 10.1186/s11671-018-2718-8
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Resurrection of Nalidixic Acid: Evaluation of Water-Based Nanoformulations as Potential Nanomedicine

Abstract: Resistance to quinolone antibiotics has been a serious problem ever since nalidixic acid was introduced into clinical medicine. Over time, resistance of pathogenic microbes to nalidixic acid led to the design of novel variants to revive its potential application. In the present work, a series of eight nanoformulations of nalidixic acid-based diacyl and sulfonyl acyl hydrazine derivatives were prepared. All nanoformulations were found to be stable at different storage temperatures. Antibacterial and anticandida… Show more

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Cited by 11 publications
(7 citation statements)
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“…Here, we explored the feasibility of using zein inks for 3D printing of tablets containing a pharmaceutical compound to show that ink-based tablets may be effective alternatives for drug release applications and personalized therapies. We used the NA antibiotic as a pharmaceutical model in our controlled release experiments from zein-printed tablets, as NA is a first-generation quinolone-based compound that is able to mitigate narrow spectrum implant-related infections. Figure A shows results of a 48 h drug-release experiment from zein-based printed tablets containing NA. A burst effect was observed for Z and ZP during the first 8 h, with a release of 29.83 ± 0.87 and 39.90 ± 2.04% of the drug, respectively.…”
Section: Resultsmentioning
confidence: 99%
“…Here, we explored the feasibility of using zein inks for 3D printing of tablets containing a pharmaceutical compound to show that ink-based tablets may be effective alternatives for drug release applications and personalized therapies. We used the NA antibiotic as a pharmaceutical model in our controlled release experiments from zein-printed tablets, as NA is a first-generation quinolone-based compound that is able to mitigate narrow spectrum implant-related infections. Figure A shows results of a 48 h drug-release experiment from zein-based printed tablets containing NA. A burst effect was observed for Z and ZP during the first 8 h, with a release of 29.83 ± 0.87 and 39.90 ± 2.04% of the drug, respectively.…”
Section: Resultsmentioning
confidence: 99%
“…1,2 However, its use has been reduced because of side effects and high resistance towards it. 6 Of the fluoroquinolones, ciprofloxacin is the most potent fluoroquinolone against gram-negative bacteria (mainly the Enterobacteriaceae species such as Escherichia coli, Salmonella, Shigella, and Neisseria). 5,7 Since its introduction, ciprofloxacin was found to be effective for a variety of bacterial infections including urinary tract infections (both complicated and uncomplicated), intra-abdominal infections, skin and bone infections, gynecological infections and sinusitis.…”
Section: Introductionmentioning
confidence: 99%
“…Here, we explored the feasibility of using zein inks for 3D-printing of tablets containing a pharmaceutical compound to show that ink-based tablets may be effective alternatives for drug release applications and personalized therapies. We used the NA antibiotic as a pharmaceutical model in our controlled release experiments from zein-printed tablets, as NA is a firstgeneration quinolone-based compound that is able to mitigate narrow spectrum implant-related infections [56][57][58]. Figure 7A shows results of a 48 h drug-release experiment from zein-based printed tablets containing NA.…”
Section: Biomedical Applications: Drug Releasementioning
confidence: 99%