2020
DOI: 10.3389/fmed.2020.585638
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Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes

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Cited by 20 publications
(17 citation statements)
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“…Small changes in HCT result in large changes in the cell-free layer, thus affecting arteriolar wall nitric oxide bioavailability and wall shear stress. 16 Interestingly, we found a trend to a greater proportion of nonsurviving patients with pale mucous membranes. Because HCT levels were not significantly different between cats with and without pale mucous membranes at admission, these findings suggest that pallor was related to an altered perfusion status instead of a low HCT.…”
Section: Discussionmentioning
confidence: 58%
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“…Small changes in HCT result in large changes in the cell-free layer, thus affecting arteriolar wall nitric oxide bioavailability and wall shear stress. 16 Interestingly, we found a trend to a greater proportion of nonsurviving patients with pale mucous membranes. Because HCT levels were not significantly different between cats with and without pale mucous membranes at admission, these findings suggest that pallor was related to an altered perfusion status instead of a low HCT.…”
Section: Discussionmentioning
confidence: 58%
“…Because a critical level of viscosity is needed to maintain microvascular patency, hemodilution induces microvascular alterations. 16 Therefore, anemic hypoxia is associated with a microcirculatory disorder that hampers tissue oxygen extraction and oxygenation. For the same degree of reduction in systemic oxygen transport, these alterations are worse in anemic than in ischemic hypoxia.…”
Section: Discussionmentioning
confidence: 99%
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“…Transfusion of artificial blood is keeping up with the amount of blood loss, so suspended animation is not necessary. A self-powered battlefield ICU transfer-drone with integral CT-scanner is requested and lifts off from the nearby medical logistics base nearby, expected arrival 7 min 19–22…”
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confidence: 99%