Resuspension of indoor aeroallergens and relationship to lung inflammation in asthmatic children

Monolayer and Multilayer Particle Deposits on Hard Surfaces: Literature Review and Implications for Particle Resuspension in the Indoor Environment

“…Dust loads reported by Thatcher and Layton (1995), Franke et al (1997), Salares et al (2009), andRaja et al (2010) were classified as monolayer deposits. Field studies by Adgate et al (1995), Rich et al (1999), Rao et al (2005), Lewis et al (2006), Johnson et al (2009), Layton and Beamer (2009), and Hoh et al (2012 reported ranges of dust loads that likely include both monolayer and multilayer deposits.…”

The Effect of Particle Deposition on Immunological Response as Measured by Cytokine Production

“…Studies have shown that exposure to particulate matter, in both human and mouse alveolar epithelial cells, in vitro, can induce expression of a variety of inflammatory cytokines (Barrett et al, 1998;Bonvallot et al, 2001;Aust et al, 2002;Adamson et al, 2004;Singal and Finkelstein, 2005a). There have been great strides in elucidating the mechanism by which particulate matter and allergenic materials promote the transcription of proinflammatory genes in alveolar epithelial cells, as well as other cells related to, or in proximity of, the respiratory tract (Glaab et al, 2005;Keinan et al, 2005;Laumbach et al, 2005;Singal and Finkelstein, 2005a;Barnes, 2008;Boverhof et al, 2008;Ciprandi and Passalacqua, 2008;Lewis et al, 2008;Matsuda et al, 2008;Pantano et al, 2008;Passalacqua and Ciprandi, 2008;Siddiqui et al, 2008;Verstraelen et al, 2008;Desai and Brightling, 2009;Ferguson et al, 2009;Hammad et al, 2009;Prefontaine et al, 2009;Qian et al, 2009;Volckens et al, 2009;Woodruff et al, 2009;Bhattacharyya et al, 2010;Burgess et al, 2010;Cao et al, 2010;Corps et al, 2010;Lambrecht and Hammad, 2010;Olin et al, 2010;Raja et al, 2010;Trivedi and Caughey, 2010;Chu and Chiang, 2011;Chustz et al, 2011;Fuchimoto et al, 2011;…”

Arthropod Allergens in Urban Homes

“…Table 3 shows the aerodynamic properties of common indoor allergens. Arthropod allergens have different aerodynamic diameters and distribution than the allergens of pet dander, moulds, and pollen (17,28). Mite allergens are mostly associated with large particles (25 μm in diameter), which are not respirable.…”

“…Allergic diseases are common chronic diseases, and their prevalence is increasing in Croatia and in many European countries (6,(15)(16)(17)(18). The geneenvironment interactions have a signifi cant role in the sensitisation and exacerbation of childhood asthma, particularly in urban households (2,3,11,19).…”

“…Bioaerosol settling is infl uenced by environmental and physical parameters such as (temperature, relative humidity and air currents) (32). Allergens in settled dust become airborne by human activity (vacuum cleaning) and air currents (17,31).…”