Resveratrol—A boon for treating Alzheimer's disease?

Anekonda, Thimmappa S.

doi:10.1016/j.brainresrev.2006.04.004

Cited by 317 publications

(184 citation statements)

References 116 publications

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“…Resveratrol, a polyphenol present in red wine, may be a very effective modulator of AD development and progression [35] . This compound could reduce oxidative stress, the secretion of Ab, decrease inflammation, protect DNA-activating SIRT1, and decrease cell death [36] .…”

Section: Polyphenols Flavonoids and Herbal Supplementsmentioning

confidence: 99%

Is antioxidant therapy effective to treat alzheimer's disease?

Lloret

Giraldo

Viña

2011

Free Radicals and Antioxidants

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Section: Polyphenols Flavonoids and Herbal Supplementsmentioning

confidence: 99%

Is antioxidant therapy effective to treat alzheimer's disease?

Lloret

Giraldo

Viña

2011

Free Radicals and Antioxidants

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“…In vitro, resveratrol exerts antiinflammatory or antiproliferative effects on numerous cell types, including macrophages and neutrophils (11,12), human mammary epithelial cells (13), 3T6 fibroblasts (14), and colon cancer cells (15). In vivo, resveratrol has shown beneficial effects in animal models of carcinogenesis (7), atherosclerosis (16), and Alzheimer's disease (17) and in a rabbit model of OA (18).…”

mentioning

confidence: 99%

The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production

Dave

Attur

Palmer

et al. 2008

Arthritis & Rheumatism

122

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Objective. To determine the effects of the antioxidant resveratrol on the functions of human chondrocytes in osteoarthritis (OA).Methods. Chondrocytes and cartilage explants were isolated from OA patients undergoing knee replacement surgery. Effects of resveratrol in the presence or absence of interleukin-1␤ (IL-1␤) stimulation were assessed by measurement of prostaglandin E 2 (PGE 2 ) and leukotriene B 4 (LTB 4 ) synthesis, cyclooxygenase (COX) activity, matrix metalloproteinase (MMP) expression, and proteoglycan production. To explore the mechanisms of action of resveratrol, its effects on mitochondrial function and apoptosis were examined by assessing mitochondrial membrane potential, ATP levels, cytochrome c release, and annexin V staining.Results. Resveratrol inhibited both spontaneous and IL-1␤-induced PGE 2 production by >20% (P < 0.05) and by 80% (P < 0.001), respectively; similarly, LTB 4 production was reduced by >50% (P < 0.05). The production of PGE 2 was inhibited via a 70-90% suppression of COX-2 expression and enzyme activity (P < 0.05). Resveratrol also promoted anabolic effects in OA explant cultures, by elevating proteoglycan synthesis and decreasing production of MMPs 1, 3, and 13. Pretreatment of OA chondrocytes with resveratrol blocked mitochondrial membrane depolarization, loss of mitochondrial biomass, and IL-1␤-induced ATP depletion. Similarly, IL-1␤-mediated induction of the apoptotic markers cytochrome c and annexin V was also inhibited by resveratrol. Exogenous addition of PGE 2 abolished the protective effects of resveratrol on mitochondrial membrane integrity, ATP levels, expression of apoptotic markers, and DNA fragmentation.Conclusion. Resveratrol protects against IL-1␤-induced catabolic effects and prevents chondrocyte apoptosis via its inhibition of mitochondrial membrane depolarization and ATP depletion. These beneficial effects of resveratrol are due, in part, to its capacity to inhibit COX-2-derived PGE 2 synthesis. Resveratrol may therefore protect against oxidant injury and apoptosis, which are main features of progressive OA.

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“…And its neuroprotective effects have been confirmed in several animal model studies. [7] As we known,the contents of resveratrol in wines are as different as grape varietes, origins,climate, vineyard,brewing technics, brewing yeasts and aging and so on. In China, the wines from three main grape regions (Ningxia Qingtongxia, Hebei Huailai and Xinjiang Changji ) performed better and better in recent years and attracted more and more attentions of researchers and brewers.…”

Section: Introductionmentioning

confidence: 99%