Resveratrol: A molecule whose time has come? And gone?

Soleas, George J.; Diamandis, Eleftherios P.; Goldberg, David M.

doi:10.1016/s0009-9120(96)00155-5

Cited by 758 publications

(493 citation statements)

References 140 publications

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“…Foods known to contain resveratrol are limited to grapes, wine, grape juice, cranberries, cranberry juice [52,53], peanuts, and peanut products [54]. It has shown that the roots of the weed Polygonum cuspidatum constitute one of the richest sources of resveratrol [55].…”

Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 99%

Oxidative Stress and Skin Cancer: An Overview

Narendhirakannan

Hannah

2012

Ind J Clin Biochem

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Skin is the largest body organ that serves as an important environmental interface providing a protective envelope that is crucial for homeostasis. On the other hand, it is a major target for toxic insult by a broad spectrum of physical and chemical agents that are capable of altering its structure and function. There are a large number of dietary contaminants and drugs can manifest their toxicity in skin. These environmental toxicants or their metabolites are inherent oxidants and/or directly or indirectly drive the production of a variety of reactive oxidants also known as reactive oxygen species. These are short-lived entities that are continuously generated at low levels during the course of normal aerobic metabolism. These are believed to activate proliferative and cell survival signaling that can alter apoptotic pathways that may be involved in the pathogenesis of a number of skin disorders. The skin possesses an array of antioxidant defense mechanisms that interact with toxicants to obviate their deleterious effect. The ''antioxidant power'' of a food is an expression of its capability both to defend the human organism from the action of the free radicals and to prevent degenerative disorders. Plants like olive trees have their own built-in protection against the oxidative damage of the sun, and these built-in protectors function as cell protectors in our own body. Although many antioxidants have shown substantive efficacy in cell culture systems and in animal models of oxidant injury, unequivocal confirmation of their beneficial effects in human populations has proven elusive.

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Section: Phytochemicals Skin Cancer and Rosmentioning

confidence: 99%

Oxidative Stress and Skin Cancer: An Overview

Narendhirakannan

Hannah

2012

Ind J Clin Biochem

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“…However, grape skin is a particularly good source of resveratrol as the fresh skin contains about 50-100 micrograms of resveratrol per gram, while in red wine its concentration ranges from 1.5 to 3.0 milligrams per liter. 79 Studies have shown that resveratrol is a potent antimutagen, antioxidant, antiinflammatory, antiproliferative, inducer of phase II drug-metabolizing enzymes, and inhibitor of cyclooxygenase and hydroperoxidase in diverse experimental systems. 80, 81 Resveratrol inhibits diverse cellular events associated with tumor initiation, promotion and progression of skin cancer and cancers of other organs.…”

Section: Resveratrolmentioning

confidence: 99%

Chemoprevention of photocarcinogenesis by selected dietary botanicals

Baliga

Katiyar

2006

Photochem Photobiol Sci

185

131

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“…Resveratrol (3,5,4′-trihydroxystilbene) is a phenolic phytoalexin produced in various plants (e.g., grapes, legumes, berries, and peanuts) in response to stress, injury, fungal infection, and ultraviolet irradiation (Aggarwal et al, 2004;Soleas et al, 1997). Epidemiological research has revealed a link between the consumption of red wine, an important source of resveratrol, and reduced risk of cardiovascular disease in France.…”

Section: Introductionmentioning

confidence: 99%