Resveratrol Alleviates Ethanol-Induced Hormonal and Metabolic Disturbances in the Rat

Abstract

Resveratrol is a polyphenol found in different plant species and having numerous health-promoting properties in animals and humans. However, its protective action against deleterious effects of ethanol is poorly elucidated. In the present study, the influence of resveratrol (10 mg/kg/day) on some hormones and metabolic parameters was determined in rats ingesting 10 % ethanol solution for two weeks. Blood levels of insulin, glucagon and adiponectin were affected by ethanol, however, resveratrol partially ameliorated these changes. Moreover, in ethanol drinking rats, liver lipid accumulation was increased, whereas resveratrol was capable of reducing liver lipid content, probably due to decrease in fatty acid synthesis. Resveratrol decreased also blood levels of triglycerides and free fatty acids and reduced γ-glutamyl transferase activity in animals ingesting ethanol. These results show that resveratrol, already at low dose, alleviates hormonal and metabolic changes induced by ethanol in the rat and may be useful in preventing and treating some consequences of alcohol consumption.

Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD+/NADH ratio

“…Dyslipidemia is demonstrated to be strongly associated with insulin resistance. In high‐dose ethanol‐treated rats, notably increased serum TG, TC, and LDL‐C concomitant with lower HDL‐C levels reflected the disturbance of lipid metabolism , and similarly, indices regarding insulin sensitivity manifested serious insulin resistance. As anticipated, we found that Res exhibited potent effects on improving insulin sensitivity as well as counteracting ethanol‐induced dyslipidemia and impaired glucose tolerance .…”

“…In high‐dose ethanol‐treated rats, notably increased serum TG, TC, and LDL‐C concomitant with lower HDL‐C levels reflected the disturbance of lipid metabolism , and similarly, indices regarding insulin sensitivity manifested serious insulin resistance. As anticipated, we found that Res exhibited potent effects on improving insulin sensitivity as well as counteracting ethanol‐induced dyslipidemia and impaired glucose tolerance . In our study, however, it should be noted that the long‐term beneficial effects of resveratrol were shown after 22 weeks in rats fed with 100 mg/kg·bw/day Res and 2.4 mg/kg·bw/day ethanol.…”

“…Although the study by Szkudelska et al. indicates that at a lower dosage (10 mg/kg·bw/day), Res also improves the hormonal and metabolic disturbances induced by 10% ethanol exposure for 2 weeks , which further confirms the effective dosages of resveratrol in insulin‐resistant animal models are very diverse and the specific action of resveratrol may largely depends on its dosages and experimental conditions . In general, it seems clear that Res indeed plays a critical role in regulating the energy efficiency ratio and alleviating lipid metabolism disorders via its positive effects on insulin sensitivity.…”

Effects of Resveratrol in Goto-Kakizaki Rat, a Model of Type 2 Diabetes

“…Resveratrol was demonstrated to exert, among others, anti-cancer [2], cardio-protective [3], neuro-protective [4], anti-oxidative [5], anti-obesity [6] and anti-inflammatory [7] effects. Moreover, its action in ameliorating non-alcoholic fatty liver disease [8] and ethanol-induced metabolic disturbances [9,10] has been relatively well documented. Resveratrol was also reported to promote mitochondrial biogenesis and to increase survival of animals exposed to a high-fat diet [11].…”

Alcoholic liver diseases: Disease spectrum, pathophysiology, oxidative stress and role of flavonoids in alcoholic liver injury

“…Inhibit oxidative stress and LPS-induced in lammation further treating ALD. (Wang, 2018(Wang, , 2017Guo, 2017;Lu, 2016;Zhou, 2017;Lu, 2018;Zhou, 2018a;Lin, 2017;Zhou, 2018b;Jiang, 2017;Li, 2018;Liu, 2018;Lee, 2018;Szkudelska et al, 2017;Ma, 2017). C57BL/6J mice It acts by ameliorating lysosomal autophagy dysfunction and can be used for prevention of ALD.…”