Resveratrol ameliorates hypoxia/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain

Karalis, Filippos; Soubasi, Vasiliki; Georgiou, Thomas; Nakas, Christos T.; Simeonidou, Constantina; Guiba-Tziampiri, Olympia; Spandou, Evangelia

doi:10.1016/j.brainres.2011.09.044

Cited by 67 publications

(54 citation statements)

References 89 publications

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“…We found that ICV COL administration produced significant motor and neurological defects, probably caused by acute caudate vascular lesion and oxido-inflammatory cerebral injury and brain herniation. Antioxidants have been shown to attenuate neuromotor deficits associated with various neurodegenerative diseases in different animal models [62,63,64]. NGN restored these motor and neurological deficits owing to its inhibitory effect on oxido-inflammatory cascade involved in SBI after ICH [65].…”

Section: Discussionmentioning

confidence: 99%

Naringin Reverses Neurobehavioral and Biochemical Alterations in Intracerebroventricular Collagenase-Induced Intracerebral Hemorrhage in Rats

et al. 2017

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Intracerebral hemorrhage (ICH) contributes to 10-15% of all strokes and is a high risk factor for morbidity and mortality as compared to other subtypes of stroke, that is, cerebral ischemia and subarachnoid hemorrhage. Oxidative stress (OS)-induced neuroinflammation and neuronal cell death contribute towards the hallmarks of ICH. Spared antioxidant levels, increased inflammatory cytokines and free radicals in ICH lead to neuronal death and exaggerate the hallmarks of ICH. Intracerebroventricular (ICV) collagenase (COL-induced neuronal cell damage and cognitive deficits form a widely recognized experimental model for ICH. Naringin (NGN), a natural antioxidant bioflavonoid, has shown potent neuroprotective effects in different neurodegenerative diseases. However, its potential is least explored in pathological conditions, such as hemorrhagic stroke. This study is aimed at exploring the protective effects of NGN against ICV-COL induced behavioral, neurological and memory deficits in rats. ICV-ICH was induced by single, unilateral intrastriatal injection of COL (1 IU in 2 µL, ICV) over 10 min. From 2nd day onwards, NGN was administered in three different doses (10, 20, and 40 mg/kg; p.o.). Animals were subjected to a battery of behavioral tests to assess behavioral changes, including neurological scoring tests (cylinder test, spontaneous motility, righting reflex, horizontal bar test, forelimb flexion), actophotometer, rotarod, Randall Selitto and von Frey. Poststroke depression and memory deficits were estimated using forced swim test and Morris water maze test, respectively. Poststroke depression, neurological and cognitive deficits were mitigated dose dependently by NGN administration. NGN administration also attenuated the nitro-OS and restored tumor necrosis factor-α and endogenous antioxidant levels. Our research demonstrates that NGN has a protective effect against ICH-induced neurocognitive deficits, along with mitigation of oxido-nitrosative and inflammatory stress.

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Section: Discussionmentioning

confidence: 99%

Naringin Reverses Neurobehavioral and Biochemical Alterations in Intracerebroventricular Collagenase-Induced Intracerebral Hemorrhage in Rats

et al. 2017

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“…Resveratrol, when administered before the HI event, was found to be a potent protective agent that diminished tissue loss (Figure 3) and consequently infarct area both in rats and mice [86,87,88]. It also preserved myelination and minimized the astroglial reactive response [86,87].…”

Section: New Approaches To Antioxidant Therapymentioning

confidence: 99%

“…It also preserved myelination and minimized the astroglial reactive response [86,87]. Additionally, its neuroprotective effects were found to be long lasting because it was able to improve long-lasting cognitive deficits induced by hypoxia–ischemia [86,87].…”

Section: New Approaches To Antioxidant Therapymentioning

confidence: 99%

Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches

Arteaga

Álvarez

Revuelta

et al. 2017

IJMS

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Hypoxic–ischemic brain damage is an alarming health and economic problem in spite of the advances in neonatal care. It can cause mortality or detrimental neurological disorders such as cerebral palsy, motor impairment and cognitive deficits in neonates. When hypoxia–ischemia occurs, a multi-faceted cascade of events starts out, which can eventually cause cell death. Lower levels of oxygen due to reduced blood supply increase the production of reactive oxygen species, which leads to oxidative stress, a higher concentration of free cytosolic calcium and impaired mitochondrial function, triggering the activation of apoptotic pathways, DNA fragmentation and cell death. The high incidence of this type of lesion in newborns can be partly attributed to the fact that the developing brain is particularly vulnerable to oxidative stress. Since antioxidants can safely interact with free radicals and terminate that chain reaction before vital molecules are damaged, exogenous antioxidant therapy may have the potential to diminish cellular damage caused by hypoxia–ischemia. In this review, we focus on the neuroprotective effects of antioxidant treatments against perinatal hypoxic–ischemic brain injury, in the light of the most recent advances.

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“…Many different pathways determining the possible actions of resveratrol have been proposed including anti-inflammatory properties, inhibition of NO toxicity, induction of neuroprotective enzymes such as heme oxygenase-1 (HO1), free radical scavenging, NF-kB mediated suppression of proinflammatory genes, upregulation of eNOS and VEGF, inhibition of MMP-9, and by mimicking ischemic preconditioning via the sirtuin pathway (53). A relationship exists between HO1 and NOS.…”

Section: Resveratrolmentioning

confidence: 99%

Antioxidant therapies in traumatic brain injury: a review

Romero-Rivera¹,

Cabeza-Morales²,

Soto-Zarate³

et al. 2017

Romanian Neurosurgery

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Abstract:Oxidative stress constitute one of the commonest mechanism of the secondary injury contributing to neuronal death in traumatic brain injury cases. The oxidative stress induced secondary injury blockade may be considered as to be a good alternative to improve the outcome of traumatic brain injury (TBI) treatment. Due to absence of definitive therapy of traumatic brain injury has forced researcher to utilize unconventional therapies and its roles investigated in the improvement of management and outcome in recent year. Antioxidant therapies are proven effective in many preclinical studies and encouraging results and the role of antioxidant mediaction may act as further advancement in the traumatic brain injury management it may represent aonr of newer moadlaity in neurosurgical aramamentorium, this kind of therapy could be a good alternative or adjuct to the previously established neuroprotection agents in TBI.

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Resveratrol ameliorates hypoxia/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain

Cited by 67 publications

References 89 publications

Naringin Reverses Neurobehavioral and Biochemical Alterations in Intracerebroventricular Collagenase-Induced Intracerebral Hemorrhage in Rats

Naringin Reverses Neurobehavioral and Biochemical Alterations in Intracerebroventricular Collagenase-Induced Intracerebral Hemorrhage in Rats

Role of Antioxidants in Neonatal Hypoxic–Ischemic Brain Injury: New Therapeutic Approaches

Antioxidant therapies in traumatic brain injury: a review

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