Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

Sulaiman, Mohamed; Matta, Mariana; Sunderesan, N. R.; Gupta, Madhu; Periasamy, Muthu

doi:10.1152/ajpheart.00418.2009

Cited by 257 publications

(213 citation statements)

References 59 publications

(65 reference statements)

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“…In some cases, these effects have been related to sirtuin activity and in others, a sirtuin-independent effect has been suggested. In any case, in our hands resveratrol have shown capacity to increase SIRT1 and SIRT3 levels in cultured cells indicating the capacity to modulate sirtuin expression (SantaCruz Calvo et al, unpublished results), accordingly with already published results (Costa Cdos et al, 2011;Kao et al, 2010;Sulaiman et al, 2010).…”

Section: Modulation Of Sirtuin Levelssupporting

confidence: 86%

Sirtuin-Dependent Metabolic Control and Its Role in the Aging Process

Calvo¹,

Navas²,

López‐Lluch³

2012

Bioenergetics

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Section: Modulation Of Sirtuin Levelssupporting

confidence: 86%

Sirtuin-Dependent Metabolic Control and Its Role in the Aging Process

Calvo¹,

Navas²,

López‐Lluch³

2012

Bioenergetics

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“…However, protein levels were significantly reduced and activity severely compromised in advanced type‐1 diabetes (3 months following STZ injection) (Sulaiman et al. 2010). We speculate that increased protein levels of SIRT1 in fructose‐fed rats may represent an adaptive response to promote tolerance against oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats

et al. 2017

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Despite the fact that skeletal muscle insulin resistance is the hallmark of type‐2 diabetes mellitus (T2DM), inflexibility in substrate energy metabolism has been observed in other tissues such as liver, adipose tissue, and heart. In the heart, structural and functional changes ultimately lead to diabetic cardiomyopathy. However, little is known about the early biochemical changes that cause cardiac metabolic dysregulation and dysfunction. We used a dietary model of fructose‐induced T2DM (10% fructose in drinking water for 6 weeks) to study cardiac fatty acid metabolism in early T2DM and related signaling events in order to better understand mechanisms of disease. In early type‐2 diabetic hearts, flux through the fatty acid oxidation pathway was increased as a result of increased cellular uptake (CD36), mitochondrial uptake (CPT1B), as well as increased β‐hydroxyacyl‐CoA dehydrogenase and medium‐chain acyl‐CoA dehydrogenase activities, despite reduced mitochondrial mass. Long‐chain acyl‐CoA dehydrogenase activity was slightly decreased, resulting in the accumulation of long‐chain acylcarnitine species. Cardiac function and overall mitochondrial respiration were unaffected. However, evidence of oxidative stress and subtle changes in cardiolipin content and composition were found in early type‐2 diabetic mitochondria. Finally, we observed decreased activity of SIRT1, a pivotal regulator of fatty acid metabolism, despite increased protein levels. This indicates that the heart is no longer capable of further increasing its capacity for fatty acid oxidation. Along with increased oxidative stress, this may represent one of the earliest signs of dysfunction that will ultimately lead to inflammation and remodeling in the diabetic heart.

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“…Cell Culture-Primary cardiomyocyte cultures were isolated from 1-day-old neonatal rats (Harlan Sprague-Dawley) as per our published procedures (10). For experiments requiring nonmuscle cells, cells were obtained during the pre-plating step and cultured for appropriate density.…”

Section: Methodsmentioning

confidence: 99%

A Novel Cardiomyocyte-enriched MicroRNA, miR-378, Targets Insulin-like Growth Factor 1 Receptor

Knezevic

Patel

Sundaresan

et al. 2012

Journal of Biological Chemistry

123

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Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy

Abstract: Sulaiman M, Matta MJ, Sunderesan NR, Gupta MP, Periasamy M, Gupta M. Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.

Cited by 257 publications

References 59 publications

Sirtuin-Dependent Metabolic Control and Its Role in the Aging Process

Sirtuin-Dependent Metabolic Control and Its Role in the Aging Process

Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats

A Novel Cardiomyocyte-enriched MicroRNA, miR-378, Targets Insulin-like Growth Factor 1 Receptor

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