Resveratrol and cardiovascular health

M, Das; Das, Dipak K.

doi:10.1016/j.mam.2010.09.001

Cited by 107 publications

(62 citation statements)

References 70 publications

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“…Resveratrol is another extensively used autophagy inducer that acts mainly by inhibiting mTOR [48] . It is a plant-derived polyphenolic substance that has mainly been found to be abundant in grapes, peanuts and red wine [49,50] .…”

Section: Pharmacological Intervention Of Autophagy In the Treatment Omentioning

confidence: 99%

“…Because of its traditionally recognized anti-oxidative and anti-inflammatory properties, this compound plays a protective role against various types of diseases, including cardiovascular diseases, malignancies, renal diseases, type II diabetes, infections and some neurological disorders [51][52][53] . Resveratrol has also been shown to play an important role in anti-atherosclerosis and vasorelaxation by inducing autophagy [48] . For example, Liu and colleagues [54] demonstrated that the application of resveratrol facilitated the efferocytosis of oxLDL-induced apoptotic cells in RAW264.7 cells by activating Sirt1-mediated autophagy, which demonstrated a protective role for resveratrol in AS in vitro and indicated that the activation of Sirt1-mediated autophagy by resveratrol might serve as a novel therapy for the treatment of AS.…”

Section: Pharmacological Intervention Of Autophagy In the Treatment Omentioning

confidence: 99%

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The roles of macrophage autophagy in atherosclerosis

Shao

Han

Zeng³

et al. 2016

Acta Pharmacol Sin

192

116

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Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiology of atherosclerosis are increasingly investigated. Autophagy is a self-protecting cellular catabolic pathway. Since its discovery, autophagy has been found to be associated with a variety of diseases, including cardiovascular diseases, malignant tumors, neurodegenerative diseases, and immune system disorders. Accumulating evidence demonstrates that autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis and cholesterol efflux. These facts suggest the induction of autophagy may be exploited as a potential strategy for the treatment of atherosclerosis. In this review we mainly discuss the relationship between macrophage autophagy and atherosclerosis and the molecular mechanisms, as well as the recent advances in targeting the process of autophagy to treat atherosclerosis.

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Section: Pharmacological Intervention Of Autophagy In the Treatment Omentioning

confidence: 99%

Section: Pharmacological Intervention Of Autophagy In the Treatment Omentioning

confidence: 99%

The roles of macrophage autophagy in atherosclerosis

Shao

Han

Zeng³

et al. 2016

Acta Pharmacol Sin

192

116

View full text Add to dashboard Cite

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“…Нутрієнти та вітаміни В6 і В12 регулюють метаболізм гомоцистеїну. Зменшення надходження в організм ЛПНЩ і харчової солі, достатній вміст у їжі фолієвої кислоти або ресвератролу -це ті харчові чинники, які мають велике значення в профі-лактиці серцево-судинних захворювань [23,43]. Фолати разом із метіоніном забезпечу-ють виробництво S-аденозилметіоніну, який є донором вуглецю для метилювання ДНК [44].…”

Section: можливості профілактики та лікування аг через епігенетичні вunclassified

Epigenetics of Arterial Hypertension

2017

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“…The mechanism of resveratrol's action is complex and is demonstrated to involve both insulin-dependent and insulin-independent effects. 11 The broad spectrum of resveratrol effects is enlarged by new data demonstrating its great potency in relation to obesity. It is well established that resveratrol exerts beneficial effects in rodents fed a high-calorie diet.…”

Section: Diabetes and Obesitymentioning

confidence: 99%

Untitled

2015

IJPSR

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ABSTRACT:Resveratrol, an antioxidant found in red wine and certain foods, has been touted as a natural way to slow aging and fight cancer, obesity, heart disease, and diabetes. It also could be accounted as an agent, which has effects to reduced risk of inflammation and blood clotting. In addition there are some studies showing that resveratrol may actually reduce the positive effect of exercise on the heart in older men, but it's important to know that its effects only last a short time after drinking red wine. As promising as it sounds, it is not yet established how resveratrol affects humans, since most studies have been conducted on animals and microbes. Because the information on resveratrol, presented in literature, pointing its health and adverse effects is full with contradictions, especially with respect to the human response, we tried to present the available information with minimal commentary, remaining as neutral as possible and allowing the reader to draw its own conclusion on recommendation of the wide increase usage of resveratrol and a prematurity of such a decision.

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Resveratrol and cardiovascular health

Cited by 107 publications

References 70 publications

The roles of macrophage autophagy in atherosclerosis

The roles of macrophage autophagy in atherosclerosis

Epigenetics of Arterial Hypertension

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