Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway

Abstract

SummaryThe role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.

Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni

“…Gaddipati et al (2003) reported that curcumin treatment suppresses the production of IL-10 mRNA at 2 and 24 h after hemorrhage/resuscitation and this action is mediated through the inhibition of NF-kB activation and activation of protein-1 (AP-1). On the other hand, other studies reported that curcumin enhances the expression of IL-10 mRNA in different cell lines (Grandjean-Laquerriere et al, 2002;Sharma et al, 2007). Our result comes in accord with the previous study of Zhang et al (2006) whom stated that curcumin treatment of chronic colitis led to an increase in the expression of IL-10 mRNA in colon mucosa but could not increases the level of IL-10 in serum.…”

Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine‐protective regulatory T cells

“…This could be due to the different experimental systems. However, in agreement with our data, curcumin had been shown to enhance IL-10 production by human T cells and mouse macrophages [48,49]. Furthermore, curcumin inhibition of NF-kB was dependent on IL-10, in that curcumin failed to inhibit NF-kB activity in IL-10 À/À mice [50].…”

Resveratrol and red wine, healthy heart and longevity

“…Resveratrol was reported to reduce the production of prostaglandin E2 (PGE2) and the formation of ROS in lipopolysaccharide (LPS)-activated microglial cells [53,54]. Moreover, resveratrol was reported to suppress the activity of T-and B-cells, and macrophages [55]. Singh et al [56] showed that resveratrol induced both caspasedependent and caspase-independent apoptosis in activated T-cells in experimental allergic encephalomyelitis-induced mice.…”