Resveratrol and endothelial function: A literature review

Parsamanesh, Negin; Asghari, Arghavan; Sardari, Saeed; Tasbandi, Aida; Jamialahmadi, Tannaz; Xu, Suowen; Sahebkar, Amirhossein

doi:10.1016/j.phrs.2021.105725

Cited by 118 publications

(81 citation statements)

References 210 publications

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“…In the present study, RSV and FA were used as treatments in the HHCY group and changes were observed in BP, serum HCY levels, oxidative stress and renal function. The results demonstrated that there was no significant change in BP in any of the experimental groups throughout the experiment, which conflicts with previous reports on the anti-hypertensive effects of RSV (25,26). A study showed that feeding SHRs with food containing RSV (4 g/kg) meant that 146 mg/kg/day RSV was available, which decreased the blood pressure of the SHRs significantly (27).…”

Section: Discussioncontrasting

confidence: 85%

Resveratrol: A new approach to ameliorate hyperhomocysteinaemia-induced renal dysfunction

Zhao

Hui

et al. 2022

Exp Ther Med

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Hypertension is a common cause of kidney injury and renal damage occurs earlier and is more serious in patients with hypertension and hyperhomocysteinaemia (HHCY). Folic acid (FA) is widely used to ameliorate the organ damage caused by HHCY. However, the effective dose of FA remains controversial and certain studies have suggested that FA increases the risk of cancer. Therefore, it is necessary to identify a safe, effective drug. Resveratrol (RSV) is a natural polyphenol antioxidant. Therefore, the present study explored the effects of RSV on renal damage in spontaneously hypertensive rats (SHRs) with HHCY and its potential underlying mechanism. SHRs were divided randomly into control, HHCY, HHCY + FA and HHCY + RSV groups. Blood pressure, plasma homocysteine, indexes of oxidative stress [serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels] and indexes of renal function [glomerular filtration rate (GFR) and urinary albumin creatinine ratio (UACR)] were assessed. The mRNA and protein expression levels of nephrin and NAPDH oxidase (NOX)2 and NOX4 were detected via reverse transcription-quantitative PCR and western blotting. The results demonstrated that there was no significant difference in BP (blood pressure) among the groups, while the levels of homocysteine (HCY) in the HHCY intervention groups were significantly increased compared with the control. Both FA and RSV decreased the level of HCY, but the decrease was more obvious in the HHCY + FA group. Compared with the control the serum SOD levels and GFR were significantly decreased in the HHCY group, whereas the serum MDA levels and UACR were significantly increased. Moreover, the NOX2 and NOX4 expression levels were significantly increased, whereas those of nephrin were significantly decreased in the HHCY group. The changes caused by HHCY were significantly counteracted in both the HHCY + FA and HHCY + RSV groups and the antioxidant effect was markedly stronger in the HHCY + RSV group. In conclusion, RSV, like FA, potentially improved the renal function damage aggravated by HHCY in SHRs. Furthermore, RSV improved renal function mainly via the inhibition of oxidative stress. RSV may be a potential safe and effective treatment for HHCY-induced hypertensive renal damage.

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Section: Discussioncontrasting

confidence: 85%

Resveratrol: A new approach to ameliorate hyperhomocysteinaemia-induced renal dysfunction

Zhao

Hui

et al. 2022

Exp Ther Med

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“…In addition, RSV counteracts atherosclerosis onset action on endothelial dysfunction, as is well known. RSV's endothelial positive effects are mediated by AMPK/SIRT1/eNOS signaling cascade in a similar manner to that of CR [142].…”

Section: From Caloric Restriction To Cr-related Nutrients: Resveratrolmentioning

confidence: 90%

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Senesi

Ferrulli

Luzi

et al. 2021

IJMS

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Type 2 diabetes (T2DM) and cardiovascular disease (CVD) are closely associated and represent a key public health problem worldwide. An excess of adipose tissue, NAFLD, and gut dysbiosis establish a vicious circle that leads to chronic inflammation and oxidative stress. Caloric restriction (CR) is the most promising nutritional approach capable of improving cardiometabolic health. However, adherence to CR represents a barrier to patients and is the primary cause of therapeutic failure. To overcome this problem, many different nutraceutical strategies have been designed. Based on several data that have shown that CR action is mediated by AMPK/SIRT1 activation, several nutraceutical compounds capable of activating AMPK/SIRT1 signaling have been identified. In this review, we summarize recent data on the possible role of berberine, resveratrol, quercetin, and L-carnitine as CR-related nutrients. Additionally, we discuss the limitations related to the use of these nutrients in the management of T2DM and CVD.

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“…Other bioactive compounds have also been suggested to exert microvascular protective actions in obesity via favourable effects on various microvascular dysfunction pathophysiological mechanisms described above. A typical example is resveratrol, a naturally occurring polyphenolic phytoalexin found in red wine that modulates endothelial function by targeting AMPK, eNOS, nuclear factor-erythroid-derived 2-related factor-2 (Nrf2), KLF2, and NF-κB [185]. In addition, polyphenol compounds such as chlorogenic acid, piceatannol, taxifolin, quercetin, fisetin, kaempferol, and caffeic acid have been shown to inhibit arginase activity and enhance endothelial function by increasing NO levels and decreasing ROS generation [186].…”

Section: Experimental Phytochemicals and Dietary Interventionsmentioning

confidence: 99%

Skeletal Muscle Microvascular Dysfunction in Obesity-Related Insulin Resistance: Pathophysiological Mechanisms and Therapeutic Perspectives

Ugwoke

Cvetko

Umek

2022

IJMS

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Obesity is a worrisomely escalating public health problem globally and one of the leading causes of morbidity and mortality from noncommunicable disease. The epidemiological link between obesity and a broad spectrum of cardiometabolic disorders has been well documented; however, the underlying pathophysiological mechanisms are only partially understood, and effective treatment options remain scarce. Given its critical role in glucose metabolism, skeletal muscle has increasingly become a focus of attention in understanding the mechanisms of impaired insulin function in obesity and the associated metabolic sequalae. We examined the current evidence on the relationship between microvascular dysfunction and insulin resistance in obesity. A growing body of evidence suggest an intimate and reciprocal relationship between skeletal muscle microvascular and glucometabolic physiology. The obesity phenotype is characterized by structural and functional changes in the skeletal muscle microcirculation which contribute to insulin dysfunction and disturbed glucose homeostasis. Several interconnected etiologic molecular mechanisms have been suggested, including endothelial dysfunction by several factors, extracellular matrix remodelling, and induction of oxidative stress and the immunoinflammatory phenotype. We further correlated currently available pharmacological agents that have deductive therapeutic relevance to the explored pathophysiological mechanisms, highlighting a potential clinical perspective in obesity treatment.

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Resveratrol and endothelial function: A literature review

Cited by 118 publications

References 210 publications

Resveratrol: A new approach to ameliorate hyperhomocysteinaemia-induced renal dysfunction

Resveratrol: A new approach to ameliorate hyperhomocysteinaemia-induced renal dysfunction

Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction

Skeletal Muscle Microvascular Dysfunction in Obesity-Related Insulin Resistance: Pathophysiological Mechanisms and Therapeutic Perspectives

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