Resveratrol and exercise

Baltaci, Saltuk Bugra; Moğulkoç, Rasim; Baltacı, Abdülkerim Kasım

doi:10.3892/br.2016.777

Cited by 52 publications

(61 citation statements)

References 82 publications

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“…Hence, the intense effort to develop dietary strategies to counter the oxidative stress caused by physical activity (11). It has been known that Vitamin C has preventive role in tissue damage which is occurred by free radicals, thereafter it has been postulated that may prevents oxidative damage in sportsmen (12).…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise

Patlar

Baltacı

Moğulkoç

et al. 2017

Ann. Appl. Sport Sci

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Background. Exercise has significant affects on free radical production. Objective. The objective of the present study was to explore the effect of vitamin C supplementation on lipid peroxidation and lactate levels in sedentary individuals who performed exhaustion exercised. Methods. 10 healthy sedentary male athletes participated to study. They were supplemented with 300 mg oral vitamin C (L-ascorbic acid, Ester-C Plus 500 mg, Solgar-USA) and subjected to acute exhaustion exercise by fatigue developed one time a week for 4 weeks. Exhaustion exercises were carried out until exhaustion developed according to Bruce protocol once a week for 4 weeks. Blood samples were collected from the subjects four times, at the beginning and at the end of the supplementation and before and after exercise, over the 4-weeks study period. The samples were used to analyze MDA, GSH, GSH-Px, CAT, SOD and NO levels by using ELISA colorimetric method and plasma lactate levels by an autoanalyzer device. Results. Exhaustion MDA, GSH, GSH-Px, CAT, SOD and NO levels measured both before and after supplementation were higher than resting levels (p<0.05). MDA, NO and lactate levels that were elevated in exhaustion before supplementation decreased significantly after vitamin C supplementation (p<0.05). Conclusion. The results of our study indicate that the increase in free radical production and lactate levels due to by 4-week exhaustion exercise were offset by vitamin C supplementation. It can be argued in conclusion that supplementation of physiologic doses of vitamin C may be useful for athlete health and performance.

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Section: Discussionmentioning

confidence: 99%

Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise

Patlar

Baltacı

Moğulkoç

et al. 2017

Ann. Appl. Sport Sci

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“…Supplementation of polyphenols like resveratrol has previously been shown to minimize the deleterious effects of exercise-induced muscle damage and aid in recovery [21]. It is therefore likely that RES could also have therapeutic application in the context of inflammatory muscle injury and may be an ergogenic aid for clinically treating muscle injuries after a contusion injury.…”

Section: Ivyspringmentioning

confidence: 99%

Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury

Hsu

Lee

et al. 2020

Int. J. Med. Sci.

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Muscle injuries frequently occur in contact sports events. The current treatment options for soft tissue injuries remain suboptimal and often result in delayed or incomplete recovery of damaged muscles. Resveratrol (RES) is a phenolic phytochemical, well-known for its antioxidant and anti-inflammatory properties. The purpose of this study is to evaluate the potential beneficial effects of RES supplementation on inflammation and regeneration in skeletal muscle after a contusion injury, in comparison to a conventional treatment of nonsteroidal anti-inflammatory drugs (NSAID). After one week of acclimation, forty eight-week-old male ICR mice were randomly divided into the five groups (n=8 per group): 1) normal control (NC), 2) mass-drop injury without any treatment (mass-drop injury, MDI), 3) post-injury NSAID treatment (MDI+ 10mg/kg NSAID), 4) post-injury RES supplementation (MDI+ 25mg/kg/day RES) and 5) post-injury treatment with RES and NSAID (MDI + resveratrol+ NSAID). After muscle contusion injury of the left gastrocnemius muscle, RES or NSAID were orally administered post-injury once a day for 7 days. Results showed that the MDI group had significantly higher serum uric acid (UA), CREA (creatinine), LDH (lactic dehydrogenase) and creatine kinase (CK) than the normal control group. Treatment with resveratrol reduced muscle damage as evidenced by the significantly decreased serum levels of UA, CREA, LDH and CK after contusion-induced muscle injuries in mice. In addition, RES and RES + NSAID groups promoted muscle satellite cell regeneration with increase in desmin protein after injury. Our results suggest that resveratrol combined with NSAID potentially improve muscle recovery and may be a potential candidate for further development as an effective clinical treatment for muscle repair.

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“…In particular, a previous study reported low miR-9 expression in the knee tissues of patients with OA which may be related with the enhanced level of apoptosis in chondrocytes (27). In addition, miR-9 can negatively regulate the expression of NFkB1, thus suggesting that a reduction in miR-9 expression may increase the expression of NF-κB and therefore inhibit cell proliferation (29,(30)(31)(32) In conclusion, treatment with Res downregulates MALAT1 expression, and MALAT1 may function as a molecular sponge of miR-9. In addition, miR-9 can directly target NF-κB, and as an inflammatory cytokine NF-κB can induce apoptosis in chondrocytes contributing to the development of OA.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of Resveratrol in the treatment of osteoarthritis via the MALAT1/miR‑9/NF‑κB signaling pathway

Zhang

Wang

et al. 2020

Exp Ther Med

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The aim of the current study was to explore the role of Resveratrol (Res) in osteoarthritis (OA) and its underlying mechanism. Reverse transcription-quantitative polymerase chain reaction and western blot analysis were used to determine the relative expression levels of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), microRNA-9 (miR-9), nuclear factor kappa B subunit 1 (NF-κB1), interleukin (IL)-6, matrix metallopeptidase 13 (MMP-13) and caspase-3 in vitro and in the in vivo model of OA, as well as examining the effect of Res on MALAT1, miR-9 and NF-κB1, IL-6, MMP-13 and caspase-3 expression levels. Immunohistochemical analysis was performed to examine NF-κB1 and MMP-13 protein levels in the in vivo model of OA. Dual-luciferase reporter assays were used to confirm the regulatory relationship between miR-9 and MALAT1 and NF-κB1, as well as examining the effect of Res on the transcriptional activation of MALAT1 promoter. Furthermore, the effect of Res on cell proliferation in vitro was examined by MTT assay. The relative mRNA expression levels of MALAT1 and NF-κB1 were significantly increased, while miR-9 expression was significantly decreased in the OA group compared with the sham group. Treatment with Res partially reversed the effects of OA on MALAT1, NF-κB1 and miR-9 expression. Similarly, the relative protein expression levels of NF-κB1, IL-6, MMP-13 and caspase-3 were significantly increased in the OA group compared with the sham group; however, treatment with Res partially reversed the effects of OA on the protein expression levels of NF-κB1, IL-6, MMP-13 and caspase-3. MALAT1 and NF-κB1 were identified as potential target genes of miR-9, and dual-luciferase assays were used to examine the effect of miR-9 on the luciferase activity of 3'UTR MALAT1 and NF-κB1. Treatment with Res suppressed the transcriptional activation of the MALAT1 promoter, thereby inhibiting MALAT1 expression. Additionally, the relative expression level of miR-9 significantly increased following treatment with Res in a dose-dependent manner, while the relative protein expression levels of NF-κB1, IL-6, MMP-13 and caspase-3 significantly decreased following treatment with Res compared with the control. Furthermore, treatment with Res significantly increased the growth rate of chondrocytes in a dose-dependent manner compared with the control. Taken together, these results suggest that direct targeting of the MALAT1/miR-9/NF-κB1/IL-6, MMP-13/caspase-3 axis may be a novel therapeutic strategy for the treatment of OA.

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Resveratrol and exercise

Cited by 52 publications

References 82 publications

Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise

Effect of Vitamin C Supplementation on Lipid Peroxidation and Lactate Levels in Individuals Performing Exhaustion Exercise

Protective Effects of Resveratrol Supplementation on Contusion Induced Muscle Injury

Therapeutic effect of Resveratrol in the treatment of osteoarthritis via the MALAT1/miR‑9/NF‑κB signaling pathway

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