Resveratrol and Lifespan in Model Organisms

Pallauf, Kathrin; Rimbach, Gerald; Rupp, Petra Maria; Chin, Dawn; Wolf, Insa M. A.

doi:10.2174/0929867323666161024151233

Cited by 68 publications

(48 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Flavonoid consumption via diet may benefit cardiovascular health in humans [1, 2], and in some cases, flavonoid supplementation prolonged lifespan of lower model organisms such as flies and worms [3]. Since many flavonoids are known to act as free radical scavengers, putative health benefits were partly attributed to their direct antioxidant capacity.…”

Section: Introductionmentioning

confidence: 99%

Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ

Pallauf

Duckstein

Hasler

et al. 2017

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Dietary flavonoids have been shown to extend the lifespan of some model organisms and may delay the onset of chronic ageing-related diseases. Mechanistically, the effects could be explained by the compounds scavenging free radicals or modulating signalling pathways. Transcription factors Nrf2, FoxO, and PPARγ possibly affect ageing by regulating stress response, adipogenesis, and insulin sensitivity. Using Hek-293 cells transfected with luciferase reporter constructs, we tested the potency of flavonoids from different subclasses (flavonols, flavones, flavanols, and isoflavones) to activate these transcription factors. Under cell-free conditions (ABTS and FRAP assays), we tested their free radical scavenging activities and used α-tocopherol and ascorbic acid as positive controls. Most of the tested flavonoids, but not the antioxidant vitamins, stimulated Nrf2-, FoxO-, and PPARγ-dependent promoter activities. Flavonoids activating Nrf2 also tended to induce a FoxO and PPARγ response. Interestingly, activation patterns of cellular stress response by flavonoids were not mirrored by their activities in ABTS and FRAP assays, which depended mostly on hydroxylation in the flavonoid B ring and, in some cases, extended that of the vitamins. In conclusion, the free radical scavenging properties of flavonoids do not predict whether these molecules can stimulate a cellular response linked to activation of longevity-associated transcription factors.

show abstract

Section: Introductionmentioning

confidence: 99%

Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ

Pallauf

Duckstein

Hasler

et al. 2017

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

show abstract

“…The specific SIRT1 activator resveratrol, a naturally occurring phytochemical product in grapes and red wine, has attracted wide attention because of its antioxidant and antiinflammatory effects (Pallauf et al, 2016). Importantly, resveratrol was also shown to mediate neuroprotection in vitro and in vivo by regulating antioxidant defenses or mitochondrial function (Pallàs et al, 2013; Torres-Pérez et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations

Zhang

Wang

et al. 2017

Front. Physiol.

View full text Add to dashboard Cite

Pb is a potential risk factor for cognition, mainly mediated by enhanced oxidative stress. Resveratrol, a natural polyphenol with crucial anti-oxidative property, is recently implicated in preventing cognitive deficits in normal aging and neurodegenerative disorders. Its beneficial effects have been linked to sirtuin 1(SIRT1) activation. The aim of this work is to investigate the possible linkage between alterations in Pb-induced oxidative damage and cognitive impairment by prolonged treatment of resveratrol. Male C57BL/6 mice were given Pb(Ac)2 treatment or deionized H2O for 12 weeks, and subjected to resveratrol gavage at the dose of 50 mg/kgBw•d or vehicle after Pb exposure. Results from biochemical analysis and immunohistofluorescence showed that Pb induced oxidative DNA damage and decreased cortical antioxidant biomarker. As expected, these abnormalities were improved by resveratrol treatment. Morris water maze test, Western blotting, immunohistofluorescence staining and RT-qPCR indicated that resveratrol ameliorated spatial learning and memory deficits with alterations in hippocampal BDNF-TrkB signaling, promoted nuclear localization and phosphorylation of hippocampal SIRT1, partly increased protein levels of AMPK and PGC-1α involving in modulation of antioxidant response in Pb-exposed mice. Our results support the hypothesis that resveratrol could attenuate Pb-induced cognitive impairment which was associated with activating SIRT1 via modulation of oxidative stress. Additionally, resveratrol also repressed the Pb-induce amyloidogenic processing with resultant decline in cortical Aβ1−−40. Noteworthy, such effects were not mediated by resveratrol treatment alone. These findings emphasize the potential of SIRT1 activator as an efficacious dietary intervention to downgrade the Pb-induced neurotoxic lesion.

show abstract

“…C. elegans hatched from eggs that were released after adult nematodes were lysed in a sodium hypochlorite‐sodium hydroxide solution as previously described (Jarapalacios et al, ; Pallauf, Rimbacha, Ruppa, China, & Wolf, ). The L1 stage C. elegans were transferred onto fresh nematode growth medium (NGM) plates covered with Escherichia coli OP50, and then incubated at 25°C.…”

Section: Methodsmentioning

confidence: 99%

An aqueous polyphenol extract from Rosa rugosa tea has antiaging effects on Caenorhabditis elegans

et al. 2019

View full text Add to dashboard Cite

Rosa rugosa aqueous polyphenol (RAP) is a kind of polyphenol from Rosa rugosa flower tea. In this study, the antiaging activities of RAP were studied in the model organism Caenorhabditis elegans. UHPLC‐HESI‐MS/MS was employed to identify the specific phenolic profile, revealing that there were 23 types of phenolic compounds in RAP and that quercetin glycoside was the principal component. RAP increased the mean lifespan of C. elegans and enhanced the thermotolerance and resistance to oxidative stress of C. elegans in a concentration‐dependent manner. Furthermore, RAP showed powerful antioxidant effects in vitro and strong protection against oxidative DNA damage. RAP significantly improved the levels of total superoxide dismutase and total antioxidant capacity of C. elegans. In conclusion, RAP has antiaging effects on C. elegans, which might be related to its powerful antioxidant effects both in vitro and in vivo. Practical applications In recent years, chronic diseases associated with aging have had a profound impact on quality of life. Many healthy foods have antiaging properties, especially flower teas, such as those made from Rosa rugosa. Our results indicated that Rosa rugosa tea is good for health and that RAP could potentially be developed as a bioactive product that could be used to combat aging.

show abstract

Resveratrol and Lifespan in Model Organisms

Abstract: It remains inconclusive whether resveratrol is indeed a CR mimetic and possesses life-prolonging properties. The limited bioavailability of resveratrol may further impede its potential effects.

Cited by 68 publications

References 0 publications

Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ

Flavonoids as Putative Inducers of the Transcription Factors Nrf2, FoxO, and PPARγ

Early-Life Exposure to Lead Induces Cognitive Impairment in Elder Mice Targeting SIRT1 Phosphorylation and Oxidative Alterations

An aqueous polyphenol extract from Rosa rugosa tea has antiaging effects on Caenorhabditis elegans

Contact Info

Product

Resources

About