Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside

Islam, Fahadul; Nafady, Mohamed H.; Islam, Md. Rezaul; Saha, Susmita; Rashid, Salma; Akter, Aklima; -Or-Rashid, Md. Harun; Akhtar, Muhammad Furqan; Perveen, Asma; Ashraf, Ghulam Md; Rahman, Md. Habibur; Sweilam, Sherouk Hussein

doi:10.1007/s12035-022-02859-7

Cited by 48 publications

(31 citation statements)

References 252 publications

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“…Moreover, the levels of the cytokines had a positive correlation with hyperactive behavior. Previous studies have demonstrated that herbal medicines and natural compounds exert beneficial effects on behavioral changes and neurological disorders through antineuroinflammatory activities and neuroprotective effects [75][76][77][78]. In this study, the oral administration of SPS reduced the levels of TNF-α and IL-6 significantly in the PFC, as well as in LPSstimulated BV2 microglial cells.…”

Section: Discussionsupporting

confidence: 50%

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

Nguyen

Choi

Shin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Psychological stress is a major exacerbating factor of atopic dermatitis (AD), a chronic in ammatory skin disease. Sopoongsan (SPS), a traditional herbal formula, has been indicated for the treatment of various skin disorders, including AD. is study investigated the e ects of SPS on a 2,4-dinitrochlorobenzene-(DNCB-) induced AD mice model exposed to social isolation (SI) stress. e severity of the AD symptoms and behavioral abnormalities was evaluated. SPS reduced the clinical skin score as evaluated with the SCORing Atopic Dermatitis (SCORAD) index and suppressed the cutaneous in ltration of T-lymphocyte cells, mast cells, and eosinophils in SI-AD mice. e SPS treatment decreased the total distance and mean speed and increased resting time in the open eld test (OFT) for these mice. In addition, the time spent in the social zone in the social interaction test also improved when SPS treatment was given. e levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in the prefrontal cortex (PFC) in the SI-AD mice were reduced by the oral administration of SPS. HaCaT and BV2 cells were used for the in vitro experiments. e pretreatment with SPS reduced the protein levels of the thymus and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in the HaCaT cells stimulated with TNF-α and interferon-gamma (IFN-c) (TI). SPS also suppressed TNF-α and IL-6 secretion in lipopolysaccharide-(LPS-) stimulated BV2 cells. ese results imply that SPS could be a promising candidate for the treatment of AD in patients under stress conditions and at risk of exacerbation.

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Section: Discussionsupporting

confidence: 50%

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

Nguyen

Choi

Shin

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Neurodegenerative disorders (NDDs) progressively affect millions worldwide as significant causes of disability and death, despite progress in considering various dysregulated routes in the pathophysiology of NDDs. The main pathophysiological processes of NDDs are still unknown [1][2][3][4]. Spinal cord injury (SCI) is an NDD that causes sensory-motor impairment and significantly lowers the standard of living.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Islam

Bepary

Nafady

et al. 2022

Oxidative Medicine and Cellular Longevity

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A spinal cord injury (SCI) occurs when the spinal cord is deteriorated or traumatized, leading to motor and sensory functions lost even totally or partially. An imbalance within the generation of reactive oxygen species and antioxidant defense levels results in oxidative stress (OS) and neuroinflammation. After SCI, OS and occurring pathways of inflammations are significant strenuous drivers of cross-linked dysregulated pathways. It emphasizes the significance of multitarget therapy in combating SCI consequences. Polyphenols, which are secondary metabolites originating from plants, have the promise to be used as alternative therapeutic agents to treat SCI. Secondary metabolites have activity on neuroinflammatory, neuronal OS, and extrinsic axonal dysregulated pathways during the early stages of SCI. Experimental and clinical investigations have noted the possible importance of phenolic compounds as important phytochemicals in moderating upstream dysregulated OS/inflammatory signaling mediators and axonal regeneration’s extrinsic pathways after the SCI probable significance of phenolic compounds as important phytochemicals in mediating upstream dysregulated OS/inflammatory signaling mediators. Furthermore, combining polyphenols could be a way to lessen the effects of SCI.

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“…In the retina of diabetic rats, oral treatment with RES-assembled gold nanoparticles (AuNPs) inhibited the activation of vascular endothelial growth factor (VEGF) 1, monocyte chemotactic protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), extracellular signal-regulated kinase (ERK) 1/2, NF- κ B, TNF- α , IL-6, and IL-1 β genes. Therefore, RES-assembled AuNPs could be used to treat diabetic retinopathy [ 145 ]. There has yet to be a report on a diabetic human clinical trial with RES nanoformulation.…”

Section: Nanoformulations In Diabetes Treatmentmentioning

confidence: 99%

Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

Islam

Khadija

Islam

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus (DM) is a fatal metabolic disorder, and its prevalence has escalated in recent decades to a greater extent. Since the incidence and severity of the disease are constantly increasing, plenty of therapeutic approaches are being considered as a promising solution. Many dietary polyphenols have been reported to be effective against diabetes along with its accompanying vascular consequences by targeting multiple therapeutic targets. Additionally, the biocompatibility of these polyphenols raises questions about their use as pharmacological mediators. Nevertheless, the pharmacokinetic and biopharmaceutical properties of these polyphenols limit their clinical benefit as therapeutics. Pharmaceutical industries have attempted to improve compliance and therapeutic effects. However, nanotechnological approaches to overcome the pharmacokinetic and biopharmaceutical barriers associated with polyphenols as antidiabetic medications have been shown to be effective to improve clinical compliance and efficacy. Therefore, this review highlighted a comprehensive and up-to-date assessment of polyphenol nanoformulations in the treatment of diabetes and vascular consequences.

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Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside

Cited by 48 publications

References 252 publications

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis

Polyphenols Targeting Oxidative Stress in Spinal Cord Injury: Current Status and Future Vision

Investigating Polyphenol Nanoformulations for Therapeutic Targets against Diabetes Mellitus

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