Resveratrol and regular exercise may attenuate hypertension-induced cardiac dysfunction through modulation of cellular stress responses

Bal, Nur Banu; Bostanci, Aykut; Sadı, Gökhan; Dönmez, Muhammet Oguzhan; Uludag, Mecit Orhan; Demirel-Yılmaz, Emine

doi:10.1016/j.lfs.2022.120424

Cited by 21 publications

(21 citation statements)

References 64 publications

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“…It lowered systolic blood pressure and increased antioxidant gene expression while reducing plasma and cardiac total antioxidant capacity in HTN. It has been demonstrated that RES and exercise can protect against heart problems caused by high blood pressure by adjusting cellular response to destructive effects of mitogenic activation, mitophagy, ER stress, NLRP3 inflammasome‐mediated inflammation, and oxidative stress (Bal et al, 2022; Rathwa et al, 2022).…”

Section: Effect On Myocardial Ischemiamentioning

confidence: 99%

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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Usually, in aerobic metabolism, natural materials including nucleic acids, proteins, and lipids can experience auxiliary injury by oxidative responses. This damage produced by reactive oxygen/nitrogen species has been identified as “oxidative stress.” As a natural polyphenol got from red wine and peanuts, resveratrol is one of the most eminent anti‐aging mixtures. Based on many studies', resveratrol hinders destructive effects of inflammatory causes and reactive oxygen radicals in several tissues. The nuclear erythroid 2‐related factor 2 is a factor related to transcription with anti‐inflammatory, antioxidant possessions which is complicated by enzyme biotransformation and biosynthesis of lipids and carbohydrates. This review provides current understanding and information about the character of resveratrol against oxidative stress and regulation of inflammation via Nrf2 signaling pathway.

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Section: Effect On Myocardial Ischemiamentioning

confidence: 99%

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Shahcheraghi

Salemi

Small

et al. 2023

Phytotherapy Research

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“…The molecular mechanism of cardiac protection is associated with the inhibition of NLRP3 inflammasome activation (Maayah et al, 2021). A recent study also showed that resveratrol (approximately 15 mg/kg/day, oral gavage for 6 weeks) and regular exercise restored systolic blood pressure and cardiac function in DOCA-salt hypertensive rats by regulating the cellular antioxidant system and NLRP3 inflammasome-mediated inflammation (Bal et al, 2022). However, resveratrol has low bioavailability due to its rapid metabolism and elimination which may limit its biological effects and require high doses for therapeutic purposes (Smoliga & Blanchard, 2014).…”

Section: Phenolsmentioning

confidence: 99%

“…A growing literature has shown that some natural products with anti-inflammatory and antioxidant properties significantly affect hypertensive TOD by modulating the NLRP3 inflammasome pathway. For example, resveratrol reduced SBP and improved cardiac function in DOCA-salt hypertensive rats by regulating the cellular antioxidant system and NLRP3 inflammasome-mediated inflammation (Bal et al, 2022). Curcumin, a polyphenol from turmeric, attenuated vascular remodeling by suppressing NF-κB and NLRP3 inflammasome activation (Han et al, 2019).…”

Section: Investigation Of Natural Productions In Hypertensive Tod Tre...mentioning

confidence: 99%

Targeting the NLRP3 inflammasome for the treatment of hypertensive target organ damage: Role of natural products and formulations

Liao,

Han,

Shen

et al. 2023

Phytotherapy Research

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Background and AimHypertension is a major global health problem that causes target organ damage (TOD) in the heart, brain, kidney, and blood vessels. The mechanisms of hypertensive TOD are not fully understood, and its treatment is challenging. This review provides an overview of the current knowledge on the role of Nod‐like receptor pyrin domain containing 3 (NLRP3) inflammasome in hypertensive TOD and the natural products and formulations that inhibit it.MethodsWe searched PubMed, Web of Science, Google Scholar, and CNKI for relevant articles using the keywords “hypertension,” “target organ damage,” “NLRP3 inflammasome,” “natural products,” and “formulations.” We reviewed the effects of the NLRP3 inflammasome on hypertensive TOD in different organs and discussed the natural products and formulations that modulate it.Key resultsIn hypertensive TOD, the NLRP3 inflammasome is activated by various stimuli such as oxidative stress and inflammation. Activation of NLRP3 inflammasome leads to the production of pro‐inflammatory cytokines that exacerbate tissue damage and dysfunction. Natural products and formulations, including curcumin, resveratrol, triptolide, and allicin, have shown protective effects against hypertensive TOD by inhibiting the NLRP3 inflammasome.Conclusions and ImplicationsThe NLRP3 inflammasome is a promising therapeutic target in hypertensive TOD. Natural products and formulations that inhibit the NLRP3 inflammasome may provide novel drug candidates or therapies for hypertensive TOD. Further studies are needed to elucidate the molecular mechanisms and optimize the dosages of these natural products and formulations and evaluate their clinical efficacy and safety.

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“…Resveratrol efficiently targets extracellular ROS when administered orally, consequently acts as a great antioxidant [9]. Furthermore, this compound displays useful effects for the treatment of cancer, hypertensive, inflammatory, Alzheimer' and metabolic diseases [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma

Ghorani‐Azam¹,

Mottaghipisheh²,

Amiri³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: In the present study, resveratrol was used to prepare complexes of cerium and nanoceria, also coated with gold (CeO2@Au core-shells) to improve the surface interactions in physiological conditions. Methods: The CeO2@Au core-shells were characterized using powder X-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), transmission electron microscope (TEM) analysis, dynamic light scattering (DLS) and ζ potential. Results: The experiment was led to the successful synthesis of nanosized CeO2@Au core-shells, although agglomeration of particles caused the distribution of the larger particles. The TEM analysis demonstrated the particles sizes ranged from 20 nm to 170 nm. Moreover, the PXRD analysis showed that both nanoceria and gold with the same crystal systems and space groups. To investigate the anticancer activity of the CeO2@Au core-shells, the cytotoxicity of the nanoparticles was investigated against liver cancerous cell lines (HepG2). Conclusions: The results indicated biosynthesized NCs have significant cellular toxicity properties against HepG2 and could be utilized in hepatocarcinoma therapy. Further in vivo investigations is proposed to be designed to assess anti-cancer and safety effects of fabricated nanocomposites.

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Resveratrol and regular exercise may attenuate hypertension-induced cardiac dysfunction through modulation of cellular stress responses

Cited by 21 publications

References 64 publications

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Resveratrol regulates inflammation and improves oxidative stress via Nrf2 signaling pathway: Therapeutic and biotechnological prospects

Targeting the NLRP3 inflammasome for the treatment of hypertensive target organ damage: Role of natural products and formulations

Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma

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