2014
DOI: 10.1016/j.intimp.2014.10.014
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Resveratrol attenuates HMGB1 signaling and inflammation in house dust mite-induced atopic dermatitis in mice

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Cited by 66 publications
(57 citation statements)
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“…Under physiological conditions, HMGB1 is mainly in the nucleus, where it acts as an architectural chromatin-binding factor to stabilize nucleosomes. During stress, HMGB1 can be released from nonlethally damaged and necrotic cells into the extracellular milieu, where it activates macrophage and induces systemic inflammation via Toll-like receptor 4 and the receptor for advanced glycosylation end products (82,83). More recent study has shown that HMGB1 acetylation plays an important role in HMGB1 localization and SIRT1 deacetylated the lysine residues (Lys-55, -88, -90 and -177) of HMGB1 (84).…”
Section: Sirt1 Suppresses Inflammation By Targeting Nf-κb and High-momentioning
confidence: 99%
“…Under physiological conditions, HMGB1 is mainly in the nucleus, where it acts as an architectural chromatin-binding factor to stabilize nucleosomes. During stress, HMGB1 can be released from nonlethally damaged and necrotic cells into the extracellular milieu, where it activates macrophage and induces systemic inflammation via Toll-like receptor 4 and the receptor for advanced glycosylation end products (82,83). More recent study has shown that HMGB1 acetylation plays an important role in HMGB1 localization and SIRT1 deacetylated the lysine residues (Lys-55, -88, -90 and -177) of HMGB1 (84).…”
Section: Sirt1 Suppresses Inflammation By Targeting Nf-κb and High-momentioning
confidence: 99%
“…The main receptors of HMGB1 on the surface of macrophages have been found to be TLR2 and TLR4, and TLR4 played an important role in neural disease (Ohtsu et al., 2017). High HMGB1 expression promotes the activation of astrocyte RAGE–MAPK signaling, which in turn promotes the expression of chemokines, cyclooxygenase 2, matrix metalloproteinase 9, and many other bioactive molecules (Karuppagounder et al., 2014), especially those involved in neuroinflammation (Karuppagounder et al., 2014). A previous study showed that HMGB1 induced the expression of interleukin (IL)‐6 and other inflammatory cytokines in brain tissues (Kiiski et al., 2017).…”
Section: Introductionmentioning
confidence: 99%
“…[21][22][23][24][25] Resveratrol (Res; trans-3,4′,5-trihydroxystilbene), a phytoalexin found in grapes, red wine, and fruit, is a potent antioxidant and anti-inflammatory agent. [26][27][28][29][30] However, its poor aqueous solubility limits its therapeutic effectiveness. In addition, oral administration of Res is challenging, owing to its low bioavailability in vivo because of its poor solubility, and thus peak plasma levels decrease rapidly.…”
mentioning
confidence: 99%