Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord

He, Xin; Ou, Peng; Wu, Kemin; Huang, Changsheng; Wang, Yichun; Yu, Zhen; Guo, Qulian

doi:10.1016/j.neulet.2014.02.022

Cited by 27 publications

(15 citation statements)

References 31 publications

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“…Conversely, the HDAC inhibitor SAHA enhanced these responses [39] (Table 1). The intrathecal injection of resveratrol suppressed the established morphine analgesic tolerance, reversed the morphine-induced decrease in spinal Sirt1, and attenuated the morphine-induced increase in spinal histone H3 acetylation [40]. Interestingly, baicalin, a flavonoid compound isolated from Huang Qin, ameliorated SNL-induced neuropathic pain by suppressing HDAC1 expression and preventing histone-H3 acetylation in the spinal cord dorsal horn [41] (Table 1).…”

Section: Histone Modification In Chronic Painmentioning

confidence: 99%

Epigenetic Regulation of Chronic Pain

et al. 2015

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Chronic pain arising from peripheral inflammation and tissue or nerve injury is a common clinical symptom. Although intensive research on the neurobiological mechanisms of chronic pain has been carried out during previous decades, this disorder is still poorly managed by current drugs such as opioids and non-steroidal anti-inflammatory drugs. Inflammation-, tissue injury-, and/or nerve injury-induced changes in gene expression in sensory neurons of the dorsal root ganglion (DRG), spinal cord dorsal horn, and pain-associated brain regions are thought to participate in chronic pain genesis; however, how these changes occur is still elusive. Epigenetic modifications including DNA methylation and covalent histone modifications control gene expression. Recent studies have shown that peripheral noxious stimulation changes DNA methylation and histone modifications and that these changes may be related to the induction of pain hypersensitivity under chronic pain conditions. This review summarizes the current knowledge and progress in epigenetic research in chronic pain and discusses the potential role of epigenetic modifications as therapeutic antinociceptive targets in this disorder.

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Section: Histone Modification In Chronic Painmentioning

confidence: 99%

Epigenetic Regulation of Chronic Pain

et al. 2015

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“…Recently, SIRT1 was demonstrated to regulate algesthesia. Upregulation of the expression of SIRT1 in the spinal dorsal horn reversed chronic morphine antinociceptive tolerance (41). Increased spinal SIRT1 expression attenuated mechanical allodynia and thermal hyperalgesia in a chronic constriction injury model (42,43), and SIRT1 has also been observed to be crucial in inflammatory diseases, including obesity, type 2 diabetes mellitus, and atherosclerosis (44,45).…”

Section: Discussionmentioning

confidence: 98%

Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords

Wang

Shi

et al. 2016

Molecular Medicine Reports

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The present study aimed to investigate the effect of resveratrol on inflammatory pain. Mice were injected intraperitoneally with lipopolysaccharide (LPS) for 5 consecutive days to induce subacute systemic inflammation. Acetic acid‑induced writhing tests and tail‑flick tests were performed following the final LPS injection. Glial fibrillary acidic protein (GFAP; an astrocyte‑specific activation marker), ionized calcium binding adapter molecule 1 (Iba‑1; a microglia‑specific activation marker) and sirtuin 1 (SIRT1) protein expression levels were detected using immunohistochemistry analysis or western blotting. Following administration of LPS for 5 days, the number of writhes increased and the tail‑flick latency decreased. Resveratrol (10 or 20 mg/kg) partly inhibited LPS‑induced hyperalgesia and prevented the increase in tumor necrosis factor‑α and interleukin 6 levels induced by LPS. LPS injection reduced the SIRT1 protein expression and increased the number of GFAP‑positive and Iba‑1‑positive cells in the spinal cord. Resveratrol increased the SIRT1 protein expression levels and decreased the number of GFAP‑positive and Iba‑1‑positive cells in LPS‑treated mice. The protective effect of resveratrol was partly blocked by a selective SIRT1 inhibitor, EX‑257. Results from the present study suggest that subacute treatment with LPS induced the activation of glial cells and hyperalgesia. Resveratrol was demonstrated to inhibit the activation of glial cells and attenuate inflammatory hyperalgesia in a SIRT1‑dependent manner.

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“…Interestingly, another lab found that intrathecal application of resveratrol attenuated morphine tolerance (MT) developed in rats after twice daily i.p. for six days [174]. They further found that Sirt 1 expression at mRNA and protein levels in the spinal cord of MT rats was significantly downregulated.…”

Section: Introductionmentioning

confidence: 99%

“…Different from studies reported by He and co-workers who applied steady amounts of morphine for 7 days to produce MT and found that Sirt1 was involved [174], Liang et al treated mice with increasing amount of morphine for 4 days and were able to detect mechanical and thermal hypersensitivity in addition to MT [181]. They treated these animals with HAT inhibitor (curcumin) and HDACi (SAHA) in the presence of morphine treatment.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic regulation of persistent pain

Bai

Ren

Dubner

2015

Translational Research

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Persistent or chronic pain is tightly associated with various environmental changes and linked to abnormal gene expression within cells processing nociceptive signaling. Epigenetic regulation governs gene expression in response to environmental cues. Recent animal model and clinical studies indicate that epigenetic regulation plays an important role in the development/maintenance of persistent pain and, possibly the transition of acute pain to chronic pain, thus shedding light in a direction for development of new therapeutics for persistent pain.

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Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord

Cited by 27 publications

References 31 publications

Epigenetic Regulation of Chronic Pain

Epigenetic Regulation of Chronic Pain

Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords

Epigenetic regulation of persistent pain

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