Resveratrol Attenuates Non-alcoholic Fatty Liver Disease in Obese Mice Modulating MAF1

Silva, Karinne Aparecida Souza; Freitas, Daniela Fernanda de; Borém, Luciana Mendes Araújo; Oliveira, Luis Paulo; Oliveira, Janaína Ribeiro; Paraíso, Alanna Fernandes; Guimarães, André Luiz Sena; De-Paula, Alfredo Maurício Batista; D'Angelis, Carlos Eduardo Mendes; Santos, Sérgio Henrique Sousa

doi:10.1007/s43450-022-00309-y

Cited by 3 publications

(4 citation statements)

References 48 publications

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“…The aim of the next study [98] was to evaluate the resveratrol effects on the MAF1 gene liver pathway using a mouse model. Male mice were divided into four groups.…”

Section: Effect Of Resveratrol On Liver Condition-animal Studiesmentioning

confidence: 99%

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Kasprzak-Drozd,

Niziński,

Kasprzak

et al. 2024

IJMS

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Metabolic dysfunction-associated steatotic liver disease (MASLD) is influenced by a variety of factors, including environmental and genetic factors. The most significant outcome is the alteration of free fatty acid and triglyceride metabolism. Lipotoxicity, impaired autophagy, chronic inflammation, and oxidative stress, as well as coexisting insulin resistance, obesity, and changes in the composition of gut microbiota, are also considered crucial factors in the pathogenesis of MASLD. Resveratrol is a polyphenolic compound that belongs to the stilbene subgroup. This review summarises the available information on the therapeutic effects of resveratrol against MASLD. Resveratrol has demonstrated promising antisteatotic, antioxidant, and anti-inflammatory activities in liver cells in in vitro and animal studies. Resveratrol has been associated with inhibiting the NF-κB pathway, activating the SIRT-1 and AMPK pathways, normalizing the intestinal microbiome, and alleviating intestinal inflammation. However, clinical studies have yielded inconclusive results regarding the efficacy of resveratrol in alleviating hepatic steatosis or reducing any of the parameters found in MASLD in human patients. The lack of homogeneity between studies, low bioavailability of resveratrol, and population variability when compared to animal models could be the reasons for this.

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“…The aim of the next study [98] was to evaluate the resveratrol effects on the MAF1 gene liver pathway using a mouse model. Male mice were divided into four groups.…”

Section: Effect Of Resveratrol On Liver Condition-animal Studiesmentioning

confidence: 99%

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Kasprzak-Drozd,

Niziński,

Kasprzak

et al. 2024

IJMS

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“…PCR assays demonstrated that RSV increased NNMT expression, which in turn blocked RXRα expression, ultimately inhibiting DNL production transcription. RSV influences lipid metabolism and MAF1 reduces intracellular lipid concentration to mitigate hepatocyte steatosis through PTEN (Silva et al, 2022). Kachlishvili et al set up two cellular models from the liver, hepatocytes Hepa1‐6 and macrophages RAW264, to examine the effect of RSV on hepatocytes.…”

Section: The Use Of Natural Products In the Treatment Of Nafldmentioning

confidence: 99%

“…Generally, the therapeutic effects of RSV involve anti-steatosis, anti-oxidative stress and anti-inflammatory effects in order to delay the progression of NAFLD. (Silva et al, 2022). Kachlishvili et al set up two cellular models from the liver, hepatocytes Hepa1-6 and macrophages RAW264, to examine the effect of RSV on hepatocytes.…”

Section: Therapeutic Effects Of Phenolic Components On Nafldmentioning

confidence: 99%

Preventive and therapeutic effects of natural products and herbal extracts onnonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Cao

Fang

Sun

et al. 2023

Phytotherapy Research

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Nonalcoholic fatty liver disease (NAFLD) is a common condition that is prevalent in patients who consume little or no alcohol, and is characterized by excessive fat accumulation in the liver. The disease is becoming increasingly common with the rapid economic development of countries. Long‐term accumulation of excess fat can lead to NAFLD, which represents a global health problem with no effective therapeutic approach. NAFLD is a complex, multifaceted pathological process that has been the subject of extensive research over the past few decades. Herbal medicines have gained attention as potential therapeutic agents to prevent and treat NAFLD due to their high efficacy and low risk of side effects. Our overview is based on a PubMed and Web of Science database search as of Dec 22 with the keywords: NAFLD/NASH Natural products and NAFLD/NASH Herbal extract. In this review, we evaluate the use of herbal medicines in the treatment of NAFLD. These natural resources have the potential to inform innovative drug research and the development of treatments for NAFLD in the future.

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“…In a randomized controlled trial, substantial improvement in steatosis, attenuation of inflammatory markers, and improvement in hepatocyte apoptosis were reported after administering 500 mg orally daily of RSV for 12 weeks to 50 NAFLD patients [108]. Silva et al, 2022 [109], using a mouse model of NAFLD, found that an HFD combined with RSV therapy significantly reduced the amount of hepatic lipid droplets [109]; by altering epigenetic processes, RSV also prevented fatty liver disease. In both in vitro and in vivo models of NAFLD, resveratrol led to the upregulation of Nrf2 at the mRNA and protein levels [44].…”

Section: Resveratrolmentioning

confidence: 99%

Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Nucera,

Bulotta,

Ruga

et al. 2023

Sci. Pharm.

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Plants are an untapped natural resource; their secondary metabolites take part in a variety of pharmacological activities, making them an essential ingredient in the synthesis of novel medications and the source of reserve resources in this process. Hepatitis and liver cancer are two conditions that can result from non-alcoholic fatty liver disease (NAFLD). NAFLD is a condition that now affects a significant section of the global population. There is a need for preventative action on predisposing factors. Due to their effectiveness and few side effects, herbal medications are frequently utilized for the prevention and treatment of NAFLD. This review discusses the pathogenetic processes of NAFLD and the evidence brought to support the potential of botanical species and their derivatives in limiting the causes that predispose to the onset of NAFLD.

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Resveratrol Attenuates Non-alcoholic Fatty Liver Disease in Obese Mice Modulating MAF1

Cited by 3 publications

References 48 publications

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Preventive and therapeutic effects of natural products and herbal extracts onnonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Natural Products for the Treatment of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

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