Resveratrol attenuates radiation‐induced salivary gland dysfunction in mice

Xu, Liping; Yang, Xi; Cai, Jing; Ma, Jianhui; Cheng, Hongyan; Zhao, Kuiling; Yang, Liping; Cao, Yukun; Qin, Qin; Zhang, Chi; Qu, Zhipeng; Sun, Xinchen

doi:10.1002/lary.24276

Cited by 37 publications

(33 citation statements)

References 42 publications

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“…19 However, in the present study, statistically significant differences could be observed between the irradiated control and the irradiated resveratrol groups, demonstrating that resveratrol had no radioprotective effect on dental tissues. These findings are not in agreement with the positive effects previously reported in the literature, such as the radioprotection of bone marrow cells and even of normal uninvolved tissue in the head and neck region, as described by Xu et al 13 and Şimşek et al 20 on the protection of salivary glands. 14,19 These differences may be explained by the different types of cells that were studied, as well as the administration of the medication performed intraperitoneally in these studies.…”

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confidence: 87%

Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats

2016

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The purpose of this study was to perform a microcomputed tomographic evaluation of the radioprotective effect of resveratrol on the volume of mandibular incisors of irradiated rats. A second aim was to make a quantitative assessment of the effect of x-ray exposure on these dental tissues. Twenty adult male rats were divided into four groups: control, irradiated control, resveratrol, and irradiated resveratrol. The resveratrol groups received 100 mg/kg of resveratrol, whereas the irradiated groups were exposed to 15 Gy of irradiation. The animals were sacrificed 30 days after the irradiation procedure, and their mandibles were removed and scanned in a microcomputed tomography unit. The images were loaded into Mimics software to allow segmentation of the mandibular incisor and assessment of its volume. The results were compared by One-way ANOVA and Tukey's post hoc test, considering a 5% significance level. The irradiated groups showed significantly diminished volumes of the evaluated teeth, as compared with the control group (p < 0.05). The resveratrol group presented higher values than those of the irradiated groups, and volumes similar to those of the control group. High radiation doses significantly affected tooth formation, resulting in alterations in the dental structure, and thus lower volumes. Moreover, resveratrol showed no effective radioprotective impact on dental tissues. Future studies are needed to evaluate different concentrations of this substance, in an endeavor to verify its potential as a radioprotector for these dental tissues.

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confidence: 87%

Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats

2016

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“…A major drawback in developing a successful treatment strategy for this condition has been the lack of clear understanding of the mechanism by which irradiation (IR) induces a decrease in salivary gland function. The studies in several animal models, including mini-pig, rats and mice, 6–11 have reported that following a single dose of IR there is a slow loss of salivary gland tissue 3 due to likely damage of progenitor cell population within the gland. 12 In addition, the effects of IR on neuronal cells as well as vasculature have also been suggested to contribute to the loss of salivary gland function and regenerative capacity.…”

Section: Introductionmentioning

confidence: 99%

“…For example, the protection of salivary gland function was seen by MnSOD-plasmid liposome gene therapy 16,17 or pretreatment with nitric oxide synthase inhibitors; reactive oxygen species scavengers, like resveratrol; hyperbaric oxygen therapy; anti-oxidants like, quercetin; and use of IR technologies that allow parts of the salivary glands that contain critical cell populations to be spared. 7–9,11,18 As well as protection afforded by TK1B (Tousled-like kinase 1B) gene therapy. 19 Alternatively, other strategies aim towards recovery of function or regeneration of tissue after IR, including stem cell transplantation methods.…”

Section: Introductionmentioning

confidence: 99%

Adenovirus-mediated hAQP1 expression in irradiated mouse salivary glands causes recovery of saliva secretion by enhancing acinar cell volume decrease

et al. 2016

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Head and neck irradiation (IR) during cancer treatment causes by-stander effects on the salivary glands leading to irreversible loss of saliva secretion. The mechanism underlying loss of fluid secretion is not understood and no adequate therapy is currently available. Delivery of an adenoviral vector encoding human aquaporin-1 (hAQP1) into the salivary glands of human subjects and animal models with radiation-induced salivary hypofunction leads to significant recovery of saliva secretion and symptomatic relief in subjects. To elucidate the mechanism underlying loss of salivary secretion and the basis for AdhAQP1-dependent recovery of salivary gland function we assessed submandibular gland function in control mice and mice 2 and 8 months after treatment with a single 15-Gy dose of IR (delivered to the salivary gland region). Salivary secretion and neurotransmitter-stimulated changes in acinar cell volume, an in vitro read-out for fluid secretion, were monitored. Consistent with the sustained 60% loss of fluid secretion following IR, a carbachol (CCh)-induced decrease in acinar cell volume from the glands of mice post IR was transient and attenuated as compared with that in cells from non-IR age-matched mice. The hAQP1 expression in non-IR mice induced no significant effect on salivary fluid secretion or CCh-stimulated cell volume changes, except in acinar cells from 8-month group where the initial rate of cell shrinkage was increased. Importantly, the expression of hAQP1 in the glands of mice post IR induced recovery of salivary fluid secretion and a volume decrease in acinar cells to levels similar to those in cells from non-IR mice. The initial rates of CCh-stimulated cell volume reduction in acinar cells from hAQP1-expressing glands post IR were similar to those from control cells. Altogether, the data suggest that expression of hAQP1 increases the water permeability of acinar cells, which underlies the recovery of fluid secretion in the salivary glands functionally compromised post IR.

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“…Administration of resveratrol reversed the reduction of saliva secretion induced by irradiation and restored salivary amylase and SOD activity. In addition, resveratrol inhibited increases in transforming growth factor β1 expression induced by radiation . This result showed that resveratrol may be used as a radioprotective agent to reduce the adverse effects, including xerostomia and mucositis, induced by radiotherapy.…”

Section: Resveratrol Sensitizes Cancer Cells To Radiotherapymentioning

confidence: 79%

Resveratrol and cancer treatment: updates

Jiang

Chen

Liu

et al. 2017

Annals of the New York Academy of Sciences

113

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Cancer, a growing health problem worldwide, affects millions of people every year. The overall survival rates of most cancers have been prolonged owing to the efforts of clinicians and scientists. However, some tumors develop resistance to chemoradiotherapeutic agents, and the cancer research community continues to search for effective sensitizers. Resveratrol, a natural polyphenolic phytoalexin, has shown promising effects in inhibiting proliferation and cancer progression in several tumor models. However, its molecular mechanisms and applications in chemotherapy and radiotherapy have yet to be fully determined. In this concise review, we highlight the role and related molecular mechanisms of resveratrol in cancer treatment. In particular, we focus on the role of resveratrol in the tumor microenvironment and the sensitization of cancer cells for chemotherapy and radiotherapy. Resveratrol shows promising efficacies in cancer treatment and may be applied in clinical therapy, but it requires further clinical study.

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Resveratrol attenuates radiation‐induced salivary gland dysfunction in mice

Abstract: RES can protect salivary glands against the negative effects of irradiation and has great potential as a treatment for successful radiotherapy in clinical practice.

Cited by 37 publications

References 42 publications

Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats

Micro-CT evaluation of the radioprotective effect of resveratrol on the mandibular incisors of irradiated rats

Adenovirus-mediated hAQP1 expression in irradiated mouse salivary glands causes recovery of saliva secretion by enhancing acinar cell volume decrease

Resveratrol and cancer treatment: updates

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