Resveratrol-Based Nanoformulations as an Emerging Therapeutic Strategy for Cancer

Abstract

Resveratrol is a polyphenolic stilbene derivative widely present in grapes and red wine. Broadly known for its antioxidant effects, numerous studies have also indicated that it exerts anti-inflammatory and antiaging abilities and a great potential in cancer therapy. Regrettably, the oral administration of resveratrol has pharmacokinetic and physicochemical limitations such as hampering its effects so that effective administration methods are demanding to ensure its efficiency. Thus, the present review explores the published data on the application of resveratrol nanoformulations in cancer therapy, with the use of different types of nanodelivery systems. Mechanisms of action with a potential use in cancer therapy, negative effects, and the influence of resveratrol nanoformulations in different types of cancer are also highlighted. Finally, the toxicological features of nanoresveratrol are also discussed.

Nano-Resveratrol: A Promising Candidate for the Treatment of Renal Toxicity Induced by Doxorubicin in Rats Through Modulation of Beclin-1 and mTOR

“…Numerous phytochemicals were found to defeat cancer cells without disturbing normal cells, exert chemoprophylaxis activities, support cancer cells' sensitivity to DXR (An et al, 2017), and improve chemotherapy-associated side effects (Choudhari et al, 2020). Resv has attracted growing interest due to its diverse, health benefits, including antioxidant activity and nephroprotection against several toxicants (Novelle et al, 2015;Rajagopal et al, 2018), specifically if used in its nanoformulation (Barbosa et al, 2019;Sharifi-Rad et al, 2021). More recently, Sharifi-Rad and others emphasized the distinctive role of N-Resv in cancer treatment as it contributes to autophagy induction in cancer cells and inhibits angiogenesis and metastasis, thus adding to other chemotherapy actions and minimizing their side effects (Sharifi-Rad et al, 2021).…”

Development, Optimization, and In Vitro Evaluation of Novel Oral Long-Acting Resveratrol Nanocomposite In-Situ Gelling Film in the Treatment of Colorectal Cancer

“…Resveratrol (3,5,4-trihydroxytrans-stilbene [Rv]) is a polyphenolic compound extracted from red grapes seeds that showed various pharmacological activities, such as anticancer and antioxidant and anti-inflammatory properties [ 1 , 2 ]. Rv has free radical scavenging activity to achieve its cancer-protective effects [ 1 , 2 , 3 ].…”

“…Resveratrol (3,5,4-trihydroxytrans-stilbene [Rv]) is a polyphenolic compound extracted from red grapes seeds that showed various pharmacological activities, such as anticancer and antioxidant and anti-inflammatory properties [ 1 , 2 ]. Rv has free radical scavenging activity to achieve its cancer-protective effects [ 1 , 2 , 3 ]. Regarding Rv’s effects on gene expression, Rv induces activation of caspases-3 and -9 and enhancement of B-cell lymphocyte-associated protein X (Bax) and tumor protein 53 (P53) expression to trigger apoptosis of cancerous cells [ 4 , 5 ].…”

“…On the other hand, Rv presents several disadvantages, such as low bioavailability, high metabolism, and instability. High Rv metabolism, especially after oral ingestion, decreases its oral bioavailability and increases the need for repetitive administration, and is associated with Rv adverse effects and diminished patient adherence and compliance [ 1 , 2 , 3 , 8 , 10 ]. Additionally, Rv is prone to chemical and physical degradation during storage [ 4 ].…”

“…The soy protein (Sp) amount was optimized based on its capability of enhancing Rv stability [ 2 ], making it less subject to be metabolized [ 4 , 10 ] and enhancing immune stimulation for use in cancer management [ 11 ]. Additionally, Sp was used for its mucosal adhesive property to increase the Rv cellular uptake, absorption, and localization on the intestinal–colonic area after Sp-Rv wet granule release from the sodium alginate (NA) gel at pH values > 6.5 [ 12 , 13 ].…”