Resveratrol: Biological and pharmaceutical properties as anticancer molecule

Abstract

There is ample evidence that shows an inverse relationship between consumption of fruit/vegetable-rich diets and the risk of cancer at various anatomical sites. In this review, we will assess and summarize recent advances on cancer prevention by resveratrol, a natural stilbenoid present in red grapes, peanuts, some common drinks, and dietary supplements. We will focus on data published within the past few years on in vivo model tumor animal studies that reinforce the chemopreventive efficacy of resveratrol against a multitude of cancers, as well as on its sensitization/ enhancing activities against tumor cells when used in combination with established chemotherapeutic and pharmaceutical agents. In addition, we will review examples resveratrol-target proteins, denoted RTPs, including the 24-kDa cytosolic protein quinone reductase 2 (NQO2) discovered in our laboratory that may confer resveratrol responsiveness to cancer cells. We will discuss the possible role of NQO2 in mediating cancer prevention by resveratrol. Our analysis of published data strengthen support that resveratrol displays novel roles in various cellular processes, and help to establish an expanded molecular framework for cancer prevention by resveratrol in vivo.

Cloning, Expression Pattern Analysis and Subcellular Localization of Resveratrol Synthase Gene in Peanut (<i>Arachis hypogaea</i> L.)

“…First-strand cDNAs were synthesized from each sample by using 50 pmol of poly(T) [12][13][14][15][16][17][18] primer and SuperScript TM III First-Strand Synthesis System according the standard protocol (Invitrogen, USA). For each sample, two separated reverse transcription reactions were pooled.…”

Controversies Surrounding the Potential Use of Histone Deacetylase Inhibitors for the Treatment of Asthma

“…Resveratrol is a potent antioxidant and anti-inflammatory agent and accumulating evidence indicates that is possesses anticarcinogenic and cardioprotective activities [64,[70][71][72][73][74].…”

Chemoprevention of prostate cancer with nutrients and supplements

“…It has sensitization/enhancing activities against tumor cells when used in combination with standard cancer chemotherapeutics. 75 Recent findings strongly suggest that suppressor of cytokine signaling (SOCS-3), an antiapoptotic molecule that is upregulated in PCa is one of the proteins that influence the ability of resveratrol and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) to cause programmed cell death in PCa. 76 Future studies should concentrate on the determination of molecular mechanisms of chemosensitization, efficacy of resveratrol combinations by clinically relevant in vivo studies, and demonstration of safety and effectiveness of combinations in humans.…”